..., instructions or products referred to in the content or advertisements. c-Kit Mast cells Metachromasia Staining Tryptase Mast cells are present in mammalian as well as nonmammalian [ 1 ] vertebrates in virtually all vascularized tissues. The first phase of research on mast cells was by von...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mast cell Allergy Material transfer FcεR1 Stem cell factor c- KIT National Institutes of Health (NIH) 10.13039/100000002 Mast cells are known...

...Tekla M. Lee-Fowler; Vamsi Guntur; John Dodam; Leah A. Cohn; Amy E. DeClue; Carol R. Reinero Background: Blockade of tyrosine kinase signaling by masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, can modulate allergic airway inflammation, but effects on lung mechanics have not been well...

...Stephen J. Galli; Mindy Tsai; Barry K. Wershil; See-Ying Tam; John J. Costa Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c- kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell...

... be dependent upon the local production of stem cell factor (SCF). Withdrawal of interleukin (IL)-3 results in mast cell apoptosis. The apoptotic changes following IL-3 deprivation are prevented by the addition of SCF which exerts its rescue effect upon interaction with its c-Kit tyrosine kinase receptor. Mast...

...Yukihiko Kitamura; Tohru Tsujimura; Tomoko Jippo; Tsutomu Kasugai; Yuzuru Kanakura Signaling through the c- kit receptor tyrosine kinase (Kit) is essential for development and survival of mast cells but not of basophils. Moreover, we recently found an activation mutation of Kit in several tumor...

...Hiroshi Nagata; Tadashi Okada; Alexandra S. Worobec; Tekli Semere; Dean D. Metcalfe The c-kit Asp816Val activating mutation is found in all patients with mastocytosis with an associated hematologic disorder, and at least in a subset of patients with indolent mastocytosis. The case of an 11-month...

... to in the content or advertisements. Allergy Anaphylaxis c- kit Cytokines FcεRI IgE antibody Mast-cell-deficient mice Mast cells Mediators Stem cell factor International Architö of Allergy.* Immunology The Paul Kallös Mem orial Lecture Int Arch Allergy Immunol 1997;113:14-22 Stephen J. Galli...

... previously [ 24 ]. Hybridization was performed with 32 P-labeled synthetic oligonucleotide probes: c-KIT: 5′-CCTTACATTCAACCGTGCCATTGTGCTTGAATGC-3′ [ 24 ]; SCF: 5′-GCTGTCTGACAATTGTACTACCATCTCGCTTATCC-3′ [ 24 ]; bcl-x L : 5′-TCCTTGTCTACGCTTTCCACGCACAGTGC-3′ [ 25 ]; bcl-2: 5′-CCGGTTCAG GTACTCAGTCATCCACAGG-3...

...Yukihiko Kitamura; Eiichi Morii; Tomoko Jippo; Akihiko Ito The development of mast cells is controlled through the cooperative effects of growth factors and nuclear transcription factors. The signals generated by the binding of stem cell factor (SCF) to c- kit receptor tyrosine kinase (KIT...

... of chemical mediators and/or of pathologic infiltration of MC in various tissues. Although the initial events leading to mastocytosis have not yet been unraveled, acquired alterations in the c-kit gene coding for the receptor of stem cell factor (SCF), a major cytokine involved in MC growth, have been...

..., a number of diagnostic (disease–related) markers have been identified in mastocytosis research. These include the mast cell enzyme tryptase, CD2, and mast cell growth factor receptor c–kit (CD117). Several gain–of–function–mutations in the kinase domain of c–kit appear to occur in mastocytosis supporting...

...Claudia Büttner; Jürgen Grabbe; Norbert Haas; Norbert T. Sepp; Gert Kunkel; Beate M. Henz Urticaria pigmentosa Mast cells c–kit Stem cell factor Urticaria pigmentosa (UP) represents the most common form of mast cell–proliferative disease (mastocytosis) in children and adults...

...Pia Welker; Jürgen Grabbe; Torsten Zuberbier; Beate M. Henz 23 4 1999 FcεRI, tryptase c–Kit Histidine decarboxylase Stem cell factor Recently, IgE has been shown to upregulate the expression of its own high affinity FcεRI receptor on murine mast cells and basophils in vitro...

..., PAI-3). In line with this ‘pro-fibrinolytic’ profile of antigens, MC supernatants induce plasminogen-to-plasmin conversion and fibrin clot lysis in vitro. The c-kit ligand SCF upregulates uPAR expression, and the release of tPA from MC. These observations point to an important role of MC in endogenous...