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1-3 of 3
Keywords: Wortmannin
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Journal Articles
Pharmacologic Study of Basophil Histamine Release Induced by Monocyte Chemotactic Protein-1 with Kinase Inhibitors
Available to PurchaseSubject Area:
Immunology and Allergy
Masaru Suzuki, Koichi Hirai, Seiichi Kitani, Toshiaki Takaishi, Hidetoshi Kihara, Tadashi Kasahara, Koji Ito, Yutaka Morita
Int Arch Allergy Immunol (1996) 111 (1): 18–22.
Published Online: 04 September 2009
...-induced histamine release by 44%. Wortmannin is a specific inhibitor of phosphatidylinositol 3 kinase (PI-3 kinase). It blocked MCP-1-induced histamine release with an IC50 of 3.3 × 10 –– 8 M indicating a role of PI-3 kinase in this reaction. KT5926, an inhibitor of myosin light chain kinase, also...
Journal Articles
Effects of Phosphatidylinositol-3-Kinase Inhibitors on Degranulation and Gene Induction in Allergically Triggered Mouse Mast Cells
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1997) 112 (4): 392–399.
Published Online: 04 September 2009
...Gunther G. Pendl; Eva E. Prieschl; Werner Thumb; Nathalie E. Harrer; Manfred Auer; Thomas Baumruker Background: Phosphatidylinositol-3-kinase (PI3-kinase) comprises an essential component in a number of signaling cascades, primarily of the growth factor type. Two specific inhibitors, wortmannin...
Journal Articles
Gene Regulation after Fc Epsilon Rl Stimulation in the Murine Mast Cell Line CPII
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1997) 113 (1-3): 39–41.
Published Online: 04 September 2009
... addressed this issue using transient transfections of a TNFα promoter-driven reporter gene and corresponding 5′ successive deletions, the two phosphoinositol-3 kinase inhibitors demethoxyviridin and wortmannin, ELISAs and Western and Southwestern blots. Results: Nuclear factor of activated T cells (NF...
