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Keywords: Wortmannin
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Journal Articles
Int Arch Allergy Immunol (1996) 111 (1): 18–22.
Published Online: 04 September 2009
...-induced histamine release by 44%. Wortmannin is a specific inhibitor of phosphatidylinositol 3 kinase (PI-3 kinase). It blocked MCP-1-induced histamine release with an IC50 of 3.3 × 10 –– 8 M indicating a role of PI-3 kinase in this reaction. KT5926, an inhibitor of myosin light chain kinase, also...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (1997) 113 (1-3): 39–41.
Published Online: 04 September 2009
... addressed this issue using transient transfections of a TNFα promoter-driven reporter gene and corresponding 5′ successive deletions, the two phosphoinositol-3 kinase inhibitors demethoxyviridin and wortmannin, ELISAs and Western and Southwestern blots. Results: Nuclear factor of activated T cells (NF...