... phenotype Dermatology Psoriasis Th1 Psoriasis is a common, chronic skin disease leading to sustained uncontrolled keratinocyte proliferation and dysfunctional differentiation. Psoriasis can be defined as a chronic inflammatory type 1/type 3 (T1/T3) disease due to its high association...

... helper (Th2) immune response is responsible for the pathogenesis of allergic asthma. To suppress the enhanced Th2 immune response, activation of the Th1 immune response has been an alternative strategy for anti-asthma therapy. In this context, effective Th1-inducing adjuvants that inhibit the development...

... by repeated application of 2,4-dinitrofluorobenzene (DNFB). Disease progression was evaluated by inflammation score, histopathology, and serum IgE level, and the effects of systemic MG132 administration were investigated. The percentages and absolute numbers for each population of Th1, Th2, and Th17 cells...

... of which both Th1 and Th17 lymphocytes have been described as being involved. The NK-associated molecule CD161 has recently been described as a marker of IL-17-producing lymphocytes. In this work we assessed the presence and the functional features of CD161 T helper lymphocytes infiltrating CD-associated...

... asthma during childhood. We attempted to clarify the molecular mechanisms by which Th1/Th2 predisposition in the host alters RSV infection and facilitates airway inflammation. Methods: A549 human airway epithelial cells were inoculated with live or UV-treated RSV after pretreatment with either...

..., instructions or products referred to in the content or advertisements. Interferon-γ Interleukin-4 Interleukin-10 Th1 Th2 Kawasaki disease International Archives of Allergy Immunology Original Paper Int Arch Allergy Immunol 1997;112:152-156 Received: May 20,1996 Accepted after revision: August...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Bet v 1 T cell epitope Interleukin-4 Interferon-γ Th1 Th2 Th0 Pathogenesis and Management lilt Arch Allergy...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hu-SCID mouse Allergic inflammation Superantigen IgE Th1 Th2 Inltmitional Arctmo of Allerg Immunology III. C ytokin e s, IgE P ro d u c tio n and M a st Cell A c tiva...

..., instructions or products referred to in the content or advertisements. CD8+ T cell Th1 Th2 Immune regulation IgE Intcmatiunal Archives of Allergy Immunology IV. T Cell Su b p o p u la tio n s, A n tig e n R ecogn ition and Immune Responses Int Arch Allergy Immunol 1997;113:160-162 B. J. Holmes PA...

..., T-nonresponder clones secreted a Th2 (IL-4, low IL-2 and low IFN-γ) or a Th1 cytokine pattern (low IL-4, high IL-2, IFN-γ levels) to peptide presentation by B cells. A comparison of EBV-B cells with activated, MHC class II expressing T cells as antigen-presenting cells (APC) revealed that T-cell...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CD8+ T cells IgE, suppression IFN-γ IL-4 Th1 Th2 VI. Regulation of IgE Synthesis Int Arch Allergy Immunol 1992;99:362-365 Mike Kenemy Alistair Noble David Diaz...

... and Allergology Istituto di Clinica Medica 3 University of Florence. Italy Key Words Cytokines Human TH1 and TH2 Subsets Abstract Human CD4+T cell clones secreting different patterns of cytokines similar to T||l and Tn2 cells described in mice have been demonstrated. These human Th1and TH2 clones are produced...

... induce Th1-dominated immune responses. Hence, CpG motifs might be used in the future as adjuvants and/or immunomodulatory agents to treat or prevent undesired Th2-dominated immune responses, such as allergy. © 2000 S. Karger AG, Basel 2000 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... dust directed naïve T cells towards Th2 responses. Exposure of DCs to barn dust elicited the development of Th1-dominated immune responses. Urban house dust contained bacterial debris almost exclusively of human commensal species (corynebacteria, streptococci) whereas barn dust comprised mainly intact...

...Atsuki Fukushima; Tamaki Sumi; Ken Fukuda; Naoki Kumagai; Teruo Nishida; Ko Okumura; Hisaya Akiba; Hideo Yagita; Hisayuki Ueno Background: Galectin-9 was recently identified as a ligand for Tim-3, which negatively regulates Th1 cells. Here, we investigated whether administration of anti-galectin-9...

...N. Bottini; F. Gloria-Bottini; A. Amante; P. Saccucci; E. Bottini Background: It is likely that besides developmental and environmental factors, genetic factors also play an important role in Th1/Th2 orientation and susceptibility to related disorders. Thus, for each genetic factor involved one...

... potential of LAB strains. Methods: The in vitro immune-stimulating effects on Th1/Th2 balance of more than 100 LAB strains were compared in splenocytes from ovalbumin-sensitized Th2-polarized mice. The in vivoanti-allergic ability of strain KW3110 was studied in the Th2-polarized model by detecting serum...

...Yuichi Nomura; Kiminori Masuda; Nobuaki Maeno; Masao Yoshinaga; Yoshifumi Kawano Background: Elevations of various cytokines, including Th1 and Th2 cytokines, have been reported in the acute phase of Kawasaki syndrome (KS). As interleukin (IL)-18 plays an important role in the Th1 cell response...

... trials as an adjuvant component of infectious disease vaccines and is currently a component of a licensed cancer vaccine, Melacine ® (Corixa Inc., Schering Plough). MPL ® has, in particular, been shown to promote Th1-type antigen specific responses. L-tyrosine is a depot adjuvant which is fully...