... ]. In asthma, it has been found that L-selectin (a molecule mediating leukocyte rolling and promoting their migration into airways) plays a crucial role in the development and control of airway hyper-responsiveness. Actually, the L-selectin expression by T cells is greatly increased in asthma patients [ 16...

... is available. Avoidance is the only measure to prevent anaphylactic reactions to peanuts. T-helper cells are of special importance for the sensitization process and the maintenance of allergic inflammation. Identifying markers of allergen-specific T-cell responses may help to develop novel treatment approaches...

... is a polymethoxyflavone found at high concentrations in the peel of various citrus fruits. In this study, we investigated the function of HMF on the growth of T cells cultured from the spleens of mice. HMF decreased the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) by anti-CD3/CD28...

...Pazit Salamon; Irit Shefler; Alon Y. Hershko; Yoseph A. Mekori Background: It has recently been reported that mast cells (MC) can be activated to degranulate and release certain cytokines in response to direct physical contact with activated but not resting T cells or their membranes. The MAPK...

...Martín Candia; Bernhard Kratzer; Winfried F. Pickl T lymphocytes equipped with clonotypic T cell antigen receptors (TCR) recognize immunogenic peptides only when presented in the context of their own major histocompatibility complex (MHC) molecules. Peptide loading to MHC molecules occurs...

... of a combination of dysregulation of the epithelial response towards environmental antigens and genetic susceptibility, resulting in inflammation and T cell-derived immune responses. In vivo animal models have long been used to study immune homeostasis of the airways but are limited by species restriction and lack...

...Bernhard Kratzer; Winfried F. Pickl This review highlights the recent key advances in the biology of CD4 + effector T cells, antigen-presenting cells, Th17 and T regulatory cells, as well as immediate effector cells, such as mast cells, basophils and eosinophils, which are critically contributing...

...+ cells and regulatory T cells in the peripheral blood upon treatment. By contrast, these cell subsets were significantly increased in the affected skin. Cytokine analysis of activated CD154-positive T cells showed a reduction of interleukin (IL)-17 but not of IL-4 or IFN-γ production. Conclusions...

...N. Yawalkar; W.J. Pichler Background: In vitro data derived from drug-specific T cell clones have revealed that heterogeneous T cell subsets with distinct phenotypes (CD4+ > CD8+) and cell functions (strong IL-5 production, cytotoxic potential) are generated. The aim of this study...

...Salome von Greyerz; Christoph Burkhart; Werner J. Pichler In recent years the involvement of T cells in allergic reactions to drugs has been well established. However, several molecular aspects of drug recognition by specific T cells remain still unclear. This review will discuss the known pathways...

...A. Schnabel; H. Renz; R. Petermann; E. Csernok; W.L. Gross Background: Lymphocytic alveolitis is a common feature of Wegener’s granulomatosis (WG) and sarcoidosis. In pulmonary sarcoidosis analysis of the T cell receptor (TCR) configuration disclosed a biased TCR repertoire in cells obtained...

... (early onset) psoriasis demonstrate inflammatory lesions with epidermal hyperproliferation and the presence of activated T cells as well as intraepidermal polymorphs as principal features. In contrast to pustular types of psoriasis, these patients show genetic susceptibility and strong association...

...Martien L. Kapsenberg; Catharien M.U. Hilkens; Henk M. Jansen; Jan D. Bos; Alies Snijders; Eddy A. Wierenga Atopic allergy is associated with allergen-specific CD4+ T cells showing a bias to production of the type-2 cytokines interleukin (IL)-4 and IL-5. There are indications that this bias is also...

...D.Z. Staynov; D.J. Cousins; T.H. Lee We have recently found a novel conserved motif in the promoters of several T-cell-expressed cytokines [human interleukin-2, -4, -5 and -13 and human and mouse granulocyte/macrophage-colony stimulating factor (GM-CSF)]. It contains a core sequence CTTGG...CCAAG...

...Werner J. Pichler; Martin Zanni; Salomé von Greyerz; Benno Schnyder; Daniela Mauri-Hellweg; Thomas Wendland To analyze whether and how T cells are involved in drug allergies, we analyzed the drug-induced activation of T cell subsets, T cell receptor V-β usage and cytokine secretion of T cells from...

...Judith Rosen Farrar; Kenneth Rainey; Alan A. Norris T cells B cells Interleukin-4 IgE Tumor Necrosis factor (TNF) Nedocromil sodium Pyranoquinoline Immunoglobulin Mast cells 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...

...Ramsay Fuleihan; Deborah Ahern; Raif S. Geha CD40 ligand (CD40L) delivers a contact-dependent signal to B cells which, in the presence of interleukin (IL)-4, drives immunoglobulin isotype switching to IgE. CD40L expression in T cells is transient, requires activation of protein kinase C and a rise...

...Francis Levy; Colette Kristofic; Christoph Heusser; Volker Brinkmann IgE isotype switching of human B cells requires physical interaction of T and B cells via surface molecules, and either IL-4 or IL-13 secreted by T cells. In this study we analyzed the role of IL-4 versus IL-13 in IgE production...

...Candida Fratazzi; Mirella Guerriero; Claudio Carini The role played by CD23 in retroviral infections is still unclear. The synergistic effects of interleukin 7 (IL-7) and sCD23 on T cell proliferation and the generation of HIV-1-specific cytotoxic T lymphocytes (CTL) in mitogen- and antigen...

...Claudio Carini; Candida Fratazzi Despite evidence for the expression of the low-affinity Fc receptor for IgE (FcεRII/CD23) in several pathological conditions, the role played by CD23 in normal human T cells is still unclear. We studied the effect of a stomal-derived cytokine, interleukin (IL-7...