...Young Ho Lee; Gwan Gyu Song Introduction: This study aimed to determine whether miR-146a and miR-499 polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). Methods: We searched the MEDLINE, EMBASE, and Cochrane databases. We performed a meta-analysis...

...Zongqing Liu; Tong Sun; Linjian Song; Xiaoxing Xue; Shuang Liu; Huihui Kuang; Liyuan Tian; Zheng Xiao Background: It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies...

...Lin Zhu; Peng Chen; Xuanjing Sun; Shuo Zhang Background: Previous studies on polymorphisms in interleukin-1 ( IL-1 ) and the risk of rheumatoid arthritis (RA)/systemic lupus erythematosus (SLE) yielded inconsistent results. Objectives: The authors performed this meta-analysis to more robustly...

...Paola Conigliaro; Paola Triggianese; Gianluca Draghessi; Claudia Canofari; Gianluca Aloe; Maria Sole Chimenti; Claudia Valeri; Carlo Nucci; Roberto Perricone; Massimo Cesareo Background: Retinal involvement in systemic lupus erythematosus (SLE) and Sjögren syndrome (SS) may be subclinical and thus...

... of autoreactive IgE in systemic lupus erythematosus (SLE) [ 46 ]. The initial study demonstrated that autoreactive IgE functioned to amplify autoimmunity by FcεRI-dependent activation of basophils, which played a key role in plasma cell expansion and survival. This latter point was also supported by additional...

...Ajax Mercês Atta; Mittermayer Barreto Santiago; Fernanda Garcia Guerra; Mariana Menezes Pereira; Maria Luiza B. Sousa Atta Background: Systemic lupus erythematosus (SLE) patients may exhibit high total IgE and antinuclear IgE antibodies (ANA-IgE). Here, we investigated the specificity of ANA-IgE...

... glomerulonephritis. pANCA also occur at low to moderate frequency in other PSV, collagen vascular disease, inflammatory bowel disease and autoimmune liver disease. In systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), pANCA of varied subspecificity have been found, including anti-MPO at low rate...

...Gisele Zandman-Goddard; Margalit Lorber; Yehuda Shoenfeld The coexistence of systemic lupus erythematosus (SLE) and thymoma is rare. We describe 2 female patients with this combination. A 48-year-old woman presented with dyspnea due to a left pleural effusion. Her past history revealed over...

... in the pathogenesis of autoimmune diseases by an attempt to demonstrate the presence of the viral genome in the leukocyte of 21 juvenile rheumatoid arthritis (JRA) patients, 20 childhood-onset systemic lupus erythematosus (SLE) patients, and 20 age-matched normals, using polymerase chain reaction (PCR) and DNA probes...

...Ilan Krause; Miri Blank; Yehuda Shoenfeld Animal models are of great value in the evaluation of novel and experimental treatments that cannot be tested directly on patients. In this article, we summarize the spectrum of murine models for systemic lupus erythematosus and antiphospholipid syndrome...

...), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD): thus, anti-A2/RA33 autoantibodies target the hnRNP proteins A2, B1, B2 (the ‘RA33 complex’), and anti-A1 autoantibodies are directed to the hnRNP proteins A1 and A1b. In SLE, anti-hnRNP-A/B antibodies frequently occur together...

...J. Alcocer-Varela; L. Llorente; D. Alarcón-Segovia Connective tissue diseases are generated by different immunoregulatory alterations. Their better knowledge may lead to new treatment modalities. In systemic lupus erythematosus (SLE), increased IL-10 production by non-T cells might exert...

...P. Hutin; A. Lamour; Y.L. Pennec; C. Soubrane; G. Dien; D. Khayat; P. Youinou Fifty patients (41 females and 9 males, ranging in age from 12 to 79 years) with systemic lupus erythematosus (SLE) and 20 normal controls were evaluated for the presence of plasma cell-free Fcγ receptor III (FcγRIII...

... in a number of kidney transplant recipients, patients with systemic lupus erythematosus, newborn infants and healthy donors. CD45RO, VLA-β1 (CD29), VLA-5α (CD49e), LFA-1 (CD11a/18), and CD2 were found to be closely coregulated on CD4+ T cells, while regulation of VLA-2α (Cd49b), VLA-4α (CD49d) and CD44...

..., aPE) were β 2 -glycoprotein-I (GPI)-dependent antibodies like anticardiolipin antibody (aCL) in patients with systemic lupus erythematosus (SLE). None of the patients with syphilis or healthy controls was positive for any GPI-dependent aPL. By contrast, GPI-dependent aCL (40%), aPS (20%), aPI (18...

...J.M. van der Zee; A.M.M. Miltenburg; C.E.H. Siegert; M.R. Daha; F.C. Breedveld IgG antiendothelial antibodies (IgG AEA), as measured by enzyme-linked immunosorbent assay, could be detected in serum samples of 38 out of 41 patients with systemic lupus erythematosus. Incubation of endothelial cells...

.... In this study, thymulin was tested in vitro for its effect on the release of IL-1α, IL-2, IL-6 and TNFα from peripheral blood mononuclear cells (PBMC) obtained from normal volunteers and patients with active systemic lupus erythematosus (SLE). In our experiments, PBMC (stimulated with LPS or PHA) were cultured...

... by testing the effects of ionic strength on binding. By ELISA, antibodies in NHS had greater binding to MC dsDNA at high ionic strengths than those in systemic lupus erythematosus sera. These results indicate that NHS have antibodies which bind bacterial dsDNA and extend the range of DNA determinants...

.... Philippe; J.C. Piette; J. Sany; C. Series; Y. Shoenfeld; P. Youinou IgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Anti-DNA Autoantibodies Sarcoidosis Systemic lupus erythematosus...