...Hye-Soo Yoo; Yoo-Seob Shin; Jing Nan Liu; Mi-Ae Kim; Hae-Sim Park Background: Previous studies have reported a higher prevalence of immunoglobulin E (IgE) specific for staphylococcal superantigens (SAg) in the nasal mucosa of patients with aspirin-exacerbated respiratory disease (AERD), associated...

... found in ‘nonallergic’ NP. Local specific IgE to staphylococcal enterotoxins has been demonstrated in NP, suggesting a possible role of superantigens as disease modifiers. These results suggest that IgE formation could be linked to the regulation of eosinophilic inflammation in nasal polyps...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immunodeficiency HLA class II deficiency MHC II deficiency Superantigens...

...T. Miethke; C. Wahl; K. Heeg; H. Wagner Superantigens are interesting for several reasons. They exhibit unusual T-cell activation characteristics, they allow to follow in vivo ligand-reactive T cells, they cause T-cell-mediated shock symptoms and they may be causally involved in certain human...

... with immunotherapy. In patients with nasal polyps, a local multiclonal IgE response has recently been described, initiated by Staphylococcus aureus -derived enterotoxins, which at least modifies the inflammatory reaction within the tissue. Evidence accumulates that these enterotoxins act as superantigens resulting...

...Hisayo Fukushima; Toshihiko Hirano; Naoko Shibayama; Keishi Miwa; Tomonobu Ito; Masukichi Saito; Haruko Sumida; Shinichi Oyake; Ryoji Tsuboi; Kitaro Oka Background:Staphylococcus aureus -producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST...

...-induced secretion of histamine from HHMC, whereas monoclonal IgM V H 6 + did not inhibit the release induced by protein Fv. Protein Fv acts as an endogenous immunoglobulin superantigen by interacting with the V H 3 domain of IgE to induce the release of mediators from HHMC. Nine volumes of sample...