... Allergens Sublingual Immunotherapy Drops have been proved effective and safe for treating seasonal AR (SAR) with or without allergic conjunctivitis patients and were available in China. We sought to further investigate the different intervention times of A. annua -sublingual immunotherapy (SLIT...

...Beina Liu; Jiapeng Feng; Sunhong Hu Introduction: While there exists considerable evidence for efficacy of sublingual immunotherapy (SLIT), its impact on the improvement of nasal signs in allergic rhinitis (AR) patients remains quite unclear. In this study, the endoscopic examination...

...Juan María Beitia; Arantza Vega Castro; Remedios Cárdenas; Maria Isabel Peña-Arellano Background: Lipid transfer proteins (LTPs) syndrome is an important cause of multiple plant food allergy in the Mediterranean area. The effectiveness of sublingual immunotherapy (SLIT) with the LTP Pru p 3 extract...

...Wenlong Liu; Qingxiang Zeng; Shengbao Yan; Changzhi Sun; Yiquan Tang; Renzhong Luo A good compliance often attributes to good efficacy and safety of sublingual immunotherapy (SLIT). However, few studies have been conducted on the safety of SLIT treatment in children. We aimed to confirm...

...Yingqin Gao; Xia Lin; Jing Ma; Xin Wei; Qiuju Wang; Meilan Wang Background: Several studies have suggested that sublingual immunotherapy (SLIT) involves a dose-response relationship and inadequate dosage might not achieve a favorable clinical effect. Objective: The aim of this prospective study...

...Mo Xian; Mulin Feng; Yan Dong; Nili Wei; Qiujuan Su; Jing Li Background: Few studies have directly compared the immunologic responses to specific subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Objective: We aimed to directly compare clinical efficacy and immunological...

... to in the content or advertisements. Allergic rhinoconjunctivitis Bronchial asthma Children Subcutaneous immunotherapy Sublingual immunotherapy Specific immunotherapy In conclusion, we showed that a prospective observational trial in a real-life setting is not only feasible but adds highly valuable...

...Long Cui; Jun Li; Yong Li; Zhongfang Xia Background: Several foreign studies have shown long-term efficacy of sublingual immunotherapy (SLIT), but data on the long-term efficacy of SLIT in China are still lacking. Objective: We aimed to prospectively evaluate the long-term efficacy of a 2-year SLIT...

..., symptom severity, and treatment efficacy are not clear. Methods: Between 2007 and 2012, we performed 4 randomized, placebo-controlled studies of sublingual immunotherapy (SLIT) on patients with Japanese cedar-induced allergic rhinitis who lived in or around Chiba, Japan. The participants were asked...

...Ayca Kiykim; Gonca Mumcu; Ismail Ogulur; Elif Karakoc-Aydiner; Haner Direskeneli; Safa Baris; Hasret Cagan; Ahmet Ozen Background: Sublingual immunotherapy (SLIT) has been successfully employed in IgE-mediated respiratory allergies. However, it is not known whether the modulation of immune...

...Katsuyo Ohashi-Doi; Hirokazu Kito; Weibin Du; Hiroshi Nakazawa; Henrik Ipsen; Pernille Gudmann; Kaare Lund Background: In sublingual immunotherapy (SLIT), the immune system is addressed by solubilized allergen that interacts with immunocompetent cells of the oral mucosa, the efficiency of which...

... of adverse reactions. Adverse reactions, especially intolerable gastrointestinal symptoms, are the most important causes of immunotherapy withdrawal. Eosinophilic esophagitis has been reported as a complication of milk, egg, and peanut oral immunotherapies and sublingual immunotherapy for respiratory...

...Satoshi Igarashi; Keisuke Suzuki; Yuki Nakamura; Kayoko Ishimaru; Chiharu Fukano; Keisuke Masuyama; Katsuyo Ohashi-Doi; Atsuhito Nakao Background: Sublingual immunotherapy (SLIT) is a safe and effective treatment for allergic rhinitis (AR). However, many issues regarding SLIT remain to be resolved...

...% of efficacy (combined symptom and medication score). Moreover, these changes were also correlated to clinical efficacy in clinical trials performed with sublingual immunotherapy (SLIT) with grass [ 27 ] and HDM tablets [ 24 ]. The primary objective of the present study was to evaluate the dose-response...

... pollen extract in a new oral formulation (CEDARTOLEN®, Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for sublingual immunotherapy (SLIT) for JC pollinosis. Methods: A total of 531 subjects with JC pollinosis were randomized into 2 groups at a ratio of 1:1 to receive daily sublingual administration...

...Li-lin Liu; Dan-dan Guo; Qiao-xia Liang; Shan Ding; Jing-ya Chen; Bing Wu; Qin Li Background: Sublingual immunotherapy (SLIT) is a clinically effective treatment in allergic conjunctivitis (AC); however, the mechanism of the underlying pharmacodynamics remains unclear. Here, we investigate...

... models of sublingual immunotherapy in BALB/c mice sensitized to either ovalbumin or birch pollen. Results:Bifidobacterium adolescentis, B. bifidum and B. longum induced h-DC maturation and polarized naïve CD4 + T cells toward interferon-γ and interleukin-10 production. B. bifidum increased CD25 high...

... immunotherapy Sublingual immunotherapy Allergen-specific immunotherapy is, along with allergen avoidance, the only specific treatment for allergic diseases [ 1,2 ]. Subcutaneous immunotherapy (SCIT) has been in use since around 1910 and may prevent new sensitizations [ 3 ] and reduce the development...

... on apple allergy is controversial. We performed a randomized study on patients with birch-apple syndrome to evaluate the outcome of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Methods: Forty patients underwent IT with a birch extract (Staloral; Stallergenes, Antony, France), 20...

...Oliver Pfaar; Christine Barth; Christine Jaschke; Karl Hörmann; Ludger Klimek Background: Sublingual immunotherapy (SLIT) allergy vaccines have an excellent safety profile, but opinions vary on their efficacy, and treatment regimens are often lengthy. This study assessed the effects of the Toll...