... human stem cell factor (rhSCF) and resembled CD34+-derived human mast cells. LAD2 cells have now been distributed worldwide. To study the impact of this transfer, we analyzed the number of investigators receiving LAD2 cells and resulting publications. Methods: Records maintained in our laboratory...

... that mast cell precursors can be grown equally well from the adherent fraction of cord blood mononuclear cells or peripheral blood in the presence of stem cell factor (SCF) or nerve growth factor [ 2, 3 ]. After 2 weeks of culture, 25% of cells express c-Kit and 40% stain for the mast cell protease tryptase...

... is associated with growth factors such as transforming growth factor (TGF)-β1 and stem cell factor (SCF). Methods: We developed a mouse model of airway remodeling, which includes smooth muscle thickening, in which ovalbumin (OVA)-sensitized mice were repeatedly exposed to intranasal OVA administration twice...

... diseases, but whether it treats CM remains unknown. Methods: The murine model of CM was induced by subcutaneous injection of 100 µg/kg recombinant murine stem cell factor (rmSCF) for a total of 17 days in Balb/c mice. Beginning on the 8th day, treatment with pimecrolimus 1% cream or vehicle was performed...

... development system of FIP1L1/PDGFRα-positive mast cells revealed the interaction between FIP1L1/PDGFRα, IL-5 and stem cell factor in the development of HES/CEL/SM. Current findings of FIP1L1/PDGFRα-positive HES/CEL are reviewed focusing on aberrant mast cell development leading to SM. A recent report has...

... be dependent upon the local production of stem cell factor (SCF). Withdrawal of interleukin (IL)-3 results in mast cell apoptosis. The apoptotic changes following IL-3 deprivation are prevented by the addition of SCF which exerts its rescue effect upon interaction with its c-Kit tyrosine kinase receptor. Mast...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mast cells c- kit Stem cell factor Basophils Mastocytoma Yukihiko Kitamura8 Tohru Tsujimuraa Tomoko Jippo* Tsutomu Kasugai' Yuzuru Kanakurab Departments of Pathology...

...Pia Welker; Jürgen Grabbe; Beate M. Czarnetzki Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT...

...J.W. Coleman; M.G. Buckley; A.M. Taylor; E.M.S. Banks; C.M.M. Williams; M.R. Holliday; J. Thompson We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene...

..., instructions or products referred to in the content or advertisements. Mast cells Mastocytosis Stem cell factor c-kit International Arrimes Allergy,* Immunology V. Effector C ells and R e gu la to rs of A lle rgic R e a ctio n s Int Arch Allergy Immunol 1997;113:184-186 Hiroshi Nagataa Tadashi...

... to in the content or advertisements. Allergy Anaphylaxis c- kit Cytokines FcεRI IgE antibody Mast-cell-deficient mice Mast cells Mediators Stem cell factor International Architö of Allergy.* Immunology The Paul Kallös Mem orial Lecture Int Arch Allergy Immunol 1997;113:14-22 Stephen J. Galli...

... to in the content or advertisements. Glycyrrhetinic acid Histidine decarboxylase Stem cell factor Protein kinase C Intenutioral Archives of Allergy», Immunology Original Paper Int Arch Allergy Immunol 1996;110:272-277 Young-Mi Leea Seiichi Hiroiac Tomoko Jippo-Kanemotoc Hyung-Ryong Kimb Tae- Yong Shinc...

...W.R. Sperr; K. Czerwenka; G. Mundigler; M.R. Müller; H. Semper; G. Klappacher; H.D. Glogar; K. Lechner; P. Valent Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n...

... precursors in cord blood in long-term cocultures of cord blood and murine fibroblasts. Since the c-kit ligand is a product of murine fibroblasts, we examined the growth effect of recombinant human c-kit ligand (stem cell factor), of recombinant murine c-kit ligand (mast cell growth factor...

...Stephen J. Galli; Mindy Tsai; Barry K. Wershil Mast cell development in mice is critically regulated by stem cell factor (SCF), a product of fibroblasts and other cell types which is a ligand for the tyrosine kinase receptor protein encoded by the proto-oncogene c- kit . In mice, recombinant SCF...

... the effect of recombinant human c- kit receptor ligand stem cell factor (rhSCF) on the release of preformed (histamine) and de novo synthesized mediators [prostaglandin D 2 (PGD 2 ) and peptide leukotriene C 4 (LTC 4 )] from mast cells purified from human lung parenchyma (HLMC). rhSCF (0.01–10 ng/ml...

... and connective tissue-type mast cells were demonstrated on histochemical analysis. The 3T3 fibroblast cell line or human trichilemmomal cell line (TL1) also generated similar molecules on retinoic acid stimulation. Anti-stem cell factor antibody presented a rather more potent inhibitory activity on RA-Pam sup...

...) 13, it still remains uncertain whether cord–blood–derived human cultured mast cells produce IL–13. Methods: Human cultured mast cells were raised from cord blood cells in the presence of stem cell factor (SCF) and IL–6. Levels of IL–13 mRNA were examined by a semiquantitative reverse transcriptase...

...Yukihiko Kitamura; Eiichi Morii; Tomoko Jippo; Akihiko Ito The development of mast cells is controlled through the cooperative effects of growth factors and nuclear transcription factors. The signals generated by the binding of stem cell factor (SCF) to c- kit receptor tyrosine kinase (KIT...

..., development, and function. Stem cell factor (SCF) is a unique mast cell growth factor, since mast cells disappear completely in the absence of SCF. However, several other cytokines such as IL-3 and IL-4 have been shown to influence mast cell proliferation and function also. This review focuses on the role...