...Ming Dong; Xin Wang; Jie Liu; Yu-Xia Zhao; Xing-Long Chen; Ke-Qiu Li; Guang Li Background: Obliterative bronchiolitis (OB) ranks as the major obstacle for long-term survival of lung transplantation patients. Rapamycin (Rapa) has recently been confirmed as an immunosuppressant for antirejection due...

...Rolf A. Hilger; Manfred Köller; Wolfgang König The influence of the immunosuppressive substances cyclosporin A (CsA), FK506 and rapamycin on inflammatory mediators from cytokine-primed human leukocytes was studied. The cells were primed with granulocyte/macrophage-colony-stimulating factor...

... of the animals with the immunosuppressive drugs rapamycin and dexamethasone but not cyclosporin, our results also suggested that distinct immunological pathways may be involved in the modulation of the chronic phase of inflammation induced by Sephadex beads in rat paws. 22 05 1995 10 10 1995 4 9...

...J.G. Meingassner; A. Stütz The macrolide antibiotics, FK 506 and rapamycin, have been reported to be potent immunosuppressive drugs. Both FK506 and rapamycin bind to the immunophilin macrophilin-12. Rapamycin, however, acts on T cells by a different mode of action which does not affect...