... of pregnancy-related adverse outcomes of biologics used for psoriasis, compared to TNF-α inhibitors, we utilized the WHO global pharmacovigilance database (1968–2024). Methods: We utilized the World Health Organization’s global pharmacovigilance database from 1968 to 2024. From over 140 million reports from...

...Aaron D. Smith; Catherine E. Lyons; James T. Patrie; Larry Borish Introduction: Psoriasis is a papulosquamous condition characterized by type 1 (T1) inflammation, while chronic rhinosinusitis (CRS) concurrent with asthma is commonly a type 2 (T2) process. Since psoriasis is predictive for higher...

...Saeeda Munir; Simeen Ber Rahman; Sadia Rehman; Nusrat Saba; Kehkashan Mazhar; Åsa Torinsson Naluai Introduction: The human leukocyte antigen ( HLA ) region on chromosome 6p21 is well known to carry the most important genetic factors in susceptibility to psoriasis. Different HLA alleles...

... of embryonic and haematopoietic origin (Box 1). The concept of the skin as an immunocompetent organ [ 1 ] can be related to pioneering surgical interventions on patients with psoriasis, a chronic relapsing skin disease characterized by irregular epidermal thickening, well-defined erythematous plaques, and T...

...Ia Khmaladze; Kutty Selva Nandakumar; Rikard Holmdahl Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26...

...Miwako Narita; Yoshinori Nishizawa; Shunpei Iwaya; Eri Oiwa; Minami Iwabuchi; Takayoshi Uchiyama; Asako Matsuyama; Masayoshi Masuko; Masuhiro Takahashi Background: Ustekinumab is currently used for the treatment of psoriasis with remarkable efficiency. However, worries about the development...

...Enno Christophers Psoriasis affects approximately 2% of the population in Western countries. Although clinically rather monomorphic, the disease presents with a number of phenotypically distinct and heterogeneous subgroups showing differences in their pathogenetic pathways. Patients with type I...

... and autochtonous human cancers, in healing wounds, and in chronic inflammatory disorders such as psoriasis and rheumatoid arthritis. All of these entities are characterized by angiogenesis, altered extracellular matrix, and variable degrees of hypoxia. In addition, two VPF/VEGF receptors, flt-1 and kdr...

... production in peripheral blood lymphocyte supernatants and skin biopsies of patients with AD (n = 19), NAD (n = 14) psoriasis (n = 6) and normal individuals (n = 13). A characteristic eosinophilia was present in AD and NAD but not in psoriasis and normal controls. The three patient groups showed...

...Marina Jovanović; Pal Boża; Djordjije Karadaglić; Silvija Brkić; Aleksandra Petrović; Neda Mimica-Dukić; Goran Anačkov; Mirjana Poljački Background: Immunologic studies indicate that psoriasis may represent an organ-integrated response. Objective: We assessed contact hypersensitivity in plaque-type...

...O. Schulte-Herbrüggen; R. Fölster-Holst; M. von Elstermann; M. Augustin; R. Hellweg Background: Nerve growth factor (NGF) is known to act as a potent mediator in neuroinflammatory processes. Recent studies point to a role of NGF in the skin pathophysiology of atopic dermatitis (AD) and psoriasis...