... burst or eosinophil peroxidase by degranulation. Eosinophil shape change and actin polymerization were also assessed by flow cytometry and confocal microscopy following stimulation with eotaxin-2 or platelet-activating factor. Results: Eosinophils from wild-type mice displayed inducible superoxide...

.... Granuloma Carrageenan Platelet-activating factor Histamine Polymorphonuclear leukocytes International Arrimes of Allergy** Immunology Ai'ssa H. Harran M. Rabeau S. Boucherie H. Brouilhet J. Benveniste INSERM U 200. Clamart. France Original Paper Int Arch Allergy Immunol 1996;110:182-186 Tissue Levels...

... antiallergic drug, on the production of platelet-activating factor (PAF), leukotriene (LT) and thromboxane (TX) induced by Ca 2+ ionophore A23187 were examined. KW-4679 at 10 μ M reduced the amount of cell-associated PAF by 52.8% in human polymorphonuclear leukocytes (PMNs). KW-4679 (1–100 μ M ) also inhibited...

...Jürg Hans Beer; Brunello Wüthrich; Arthur von Felten Platelet-activating factor (PAF) is released in IgE-mediated allergic diseases. The normal level, the method of its determination and its clinical importance are subject of controversy. We hypothesized that a functional assay could help to better...

... of anti-ICAM-1 monoclonal antibody (mAb) and anti-VCAM-1 mAb on transendothelial migration of human eosinophils and neutrophils across IL-1- and IL-4-stimulated cultured vascular endothelial cells. We also studied the effect of a selective antagonist for platelet-activating factor (PAF...

...Haruhiko Manabe; Kaori Akuta; Kyoko Okamura; Kenji Ohmori Phosphodiesterase (PDE) 4 inhibitors are well known for their inhibitory effect on bronchoconstriction and inflammation and may be promising anti-asthma drugs. Platelet-activating factor (PAF) has been proposed as an inflammatory mediator...

...Masafumi Arima; Ken-ichi Manaka; Takeshi Fukuda; Souhei Makino Platelet-activating factor (PAF) has been implicated in the pathogenesis of allergic disease, particularly bronchial asthma, by recruitment and activation of inflammatory cells. In an effort to further elucidate this function of PAF...

...Seishi Kishimoto; Wataru Shimadzu; Takashi Izumi; Takao Shimizu; Hironori Sagara; Takeshi Fukuda; Sohei Makino; Takayuki Sugiura; Keizo Waku Platelet-activating factor (PAF) modulates the functions of eosinophils, which play an important role in allergic inflammation, through a specific receptor(s...

...Seishi Kishimoto; Wataru Shimazu; Takashi Izumi; Takao Shimizu; Takeshi Fukuda; Sohei Makino; Takayuki Sugiura; Keizo Waku The effects of interleukin-3 (IL-3), IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) on the surface expression of platelet-activating factor (PAF) receptor...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Airway hyperresponsiveness Airway inflammation Brown Norway rat Flurbiprofen Methysergide 5-Lipoxygenase Platelet-activating factor...

... allergic inflammatory mediators on the ciliary activity has been well studied. However, ciliary responsiveness to platelet-activating factor (PAF) is yet to be established conclusively. Our study concerns the response of normal tracheal cilia from the guinea pig during an in vitro contact with PAF. PAF...

...Nobana Hayashi; Junichi Chihara; Yohnosuke Kobayashi; Tomokazu Kakazu; Dai Kurachi; Takahiro Yamamoto; Shigenori Nakajima The effect of platelet-activating factor (PAF) and platelet factor 4 (PF4) on the adhesion of isolated human eosinophils or eosinophilic cell lines (EoL-1, EoL-3) was examined...

...Hiroshi Saito; Takehiro Koshio; Yukiyoshi Yanagihara; Kazuo Akiyama; Takao Shida Platelet-activating factor (PAF)-induced augmentation of spontaneous differentiation into eosinophil-lineage cells from hematopoietic precursor cells was found among human umbilical cord blood mononuclear cells (CBMCs...

...Michele Columbo; Edward M. Horowitz; Jane McKenzie-White; Anne Kagey-Sobotka; Lawrence M. Lichtenstein We studied the effect of several compounds that influence different cell activation steps on platelet-activating factor (PAF)-induced basophil histamine secretion. Isobutylmethylxanthine (1–100 μ...

... demonstrated that formoterol inhibited antigen-induced late asthmatic response (LAR) and accompanying airway eosinophilia in guinea pigs. In this study, we investigated the direct effect of formoterol in vitro on human eosinophil function, focusing on platelet-activating factor (PAF)-induced eosinophil...

...Sandra A.C. Perez; Patrícia M.R. e Silva; Marco A. Martins; Marcia C. El-Cheikh; Renato S.B. Cordeiro; Radovan Borojevic In previous research, we have observed that intrathoracic administration of platelet-activating factor-acether (PAF) promoted a delayed eosinophilia in the pleural cavity of rats...

... (Acetosyringenin) is by far the most active compound preventing allergen- and PAF-induced bronchial obstruction by more than 80% after one single dose of 0.5 mg (aerosol). Acetophenones Androsin Bronchial asthma, guinea pig Ovalbumin Platelet-activating factor Phenol glycosides Picrorrhiza kurroa ©...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelet-activating factor...

...Sandor Sipka; Matyas Koltai; Pierre Braquet; Gyula Szegedi Using human platelet-rich plasma (PRP) we found that histamine concentration-dependently potentiated platelet aggregation induced by platelet-activating factor (PAF). When added separately, neither histamine nor chloropyramine...

...W. Dorsch; M. Bittinger; A. Kaas; A. Müller; B. Kreher; H. Wagner A methanolic extract from Galphimia glauca (320 mg/kg, orally) inhibited acute bronchial reactions to allergen (ovalbumin, 10 mg/ml) and platelet-activating factor (PAF, 1 μg/ml) inhalation challenges, but not to histamine...