... Asthma Subepithelial fibrosis TGF-β 1 Airway remodeling Phospholipase A2 The incidence of chronic inflammatory disorders such as respiratory and allergic diseases is increasing worldwide, in spite of considerable understanding of their pathogenesis and improved therapeutic strategies...

... not inhibit either phospholipase A2 activity, measured by the release of 3 H-arachidonic acid (AA), or LTC 4 synthase and LTA 4 hydrolase activities, measured with LTA 4 -free acid as substrate. The synthesis of LTC 4 and LTB 4 from AA in RBL-1 cell lysates in the presence of Ca 2+ was inhibited by honokiol...

... the Active Site of the Enzyme Im plications w ith Respect to a Paracrine A ctivation o f Th2 C ells for an IgE A n tib o d y Response Key W ords Phospholipase A2 T-cell epitopes Peptides IgE Enzymatic activity A b s tra c t Recombinant, enzymatic active phospholipase A2 from bee venom (PLA2) is a potent...

..., Boehringer Mannheim, Penzberg, Germany Inhibition of Allergic and NonAllergic Inflammation by Phospholipase A 2Inhibitors Key Words Phospholipase A2 Leukotrienes Prostaglandins Cytokines Inflammation Introduction There is now ample evidence that phospholipases A2 (PLA2)s are involved in inflammatory...

... Ibudilast KC-404 FPL-55712 Slow reacting substance of anaphylaxis Leukotriene D4 Platelet activating factor Anaphylactic bronchoconstriction Phospholipase A2 5-Lipoxygenase Abstract The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA...

... hemocyanin Phospholipase A2 Abstract The antigen dose-dependent production of IgE versus IgG2a antibodies has been investigated using keyhole limpet hemocyanin (KLH) and bee venom phospholipase A2 (PLA2) as antigens. Repeated injections of minute doses (0.1 ¡ig/mouse) of KLH into CBA/J mice lead...

.... Jäger Department of Clinical Immunology, Friedrich Schiller University Jena, FRO Characterization of Murine Monoclonal Antibodies to Phospholipase A 2and Mellitin from Bee Venom Key Words Bee venom Monoclonal antibodies Phospholipase A2 Mellitin Epitope mapping Binding assay, two-site Abstract 9 murine...

...José M. Carballido; Nicole Carballido-Perrig; Christoph Heusser; Kurt Blaser Human T-cell clones to bee venom phospholipase A2 (PLA), isolated from allergic, hyposensitized and hyperimmune individuals to bee sting, secrete both IL-4 and IFN-γ after antigen stimulation. However, the production of IL...

... Phospholipase A2 Abstract Background: Peroxynitrite (ONOO the product of the reaction between the superoxide anion ( O2 ) and nitric oxide (NO), is produced during in ammatory disease and may be a major cytotoxic agent. No reports are available as to whether ONOO generates or modulates in ammatory mediator...

.... Objectives: To determine the effects of acute restraint stress on the initiation of allergic rhinitis in a murine model. Methods: CBA/J mice were repeatedly intranasally sensitized with phospholipase A2 (PLA2) from honeybee venom without adjuvant. Restraint stress was applied using uniform cylinders once...