...) are the key drugs in the treatment of autoimmune diseases. Methotrexate (MTX) is widely used for treating RA because of its anti-inflammatory action. Meanwhile, MTX is teratogenic for the fetus and even used for abortion, so it is forbidden in pregnant women with RA. It is recommended to conception after...

.... Bricitinib JAK-STAT pathway JAK inhibitors Methotrexate Cytokine Angiotensin-converting enzyme inhibitor Angiotensin receptor blocker After the sudden emergence of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) in Wuhan, China, in December 2019, coronavirus disease 2019 (COVID-19...

...Yoshiki Gonokami; Shin-ichi Konno; Masatsugu Kurokawa; Mitsuru Adachi To understand the mechanism of antiasthmatic property of the antimetabolite agent, methotrexate (MTX), we examined its effect on time-related changes in specific airway resistance, bronchial responsiveness, and accumulation...

...Masahiko Mihara; Nobuyuki Takagi; Kazumi Urakawa; Yoichiro Moriya; Yasuhisa Takeda We compared a novel unpolyglutamable antifolate, MX-68, with polyglutamable antifolate, methotrexate (MTX), for treatment of an autoimmune kidney disease which develops spontaneously in MRL/Mp-lpr/lpr (MRL/lpr) mice...

...Jaw-Ji Tsai; Jen-Fu Shin; Chung-Hwa Chen; Soo-Ray Wang Methotrexate pneumonitis is one of the most unpredictable and potentially serious adverse effects associated with the use of low-dose pulse methotrexate in treating rheumatoid arthritis. However, its occurrence in treating bronchial asthma has...