...Alicia Armentia; Fernando Pineda; Sara Fernandez-Cortés; Angela Moro; Blanca Martin-Armentia; Paula Mendez; Ana Porcuna; Jorge Mendez-Alcalde Background: Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen...

...Almudena Matito; José Mario Morgado; Paula Sánchez-López; Iván Álvarez-Twose; Laura Sánchez-Muñoz; Alberto Orfao; Luis Escribano Background: The role of anesthesia as an elicitor of mast cell (MC) mediator release symptoms in mastocytosis is poorly investigated. Objective: To determine...

...Magdalena Lange; Anton yawrocki; Bogus"aw Nedoszytko; Bartosz Wasag; Marek Niedoszytko; Ewa Jassem; Roman Nowicki; Micha" A. ymijewski; Wojciech Biernat Background: Neoplastic mast cells involving the bone marrow (BMMCs) of patients with mastocytosis display an aberrant expression of CD25...

...H.-P. Horny; K. Sotlar; P. Valent Mast cell activation syndromes (MCAS) are clinically defined disease states with a largely unknown morphological background. Since mastocytosis may be associated with MCAS, it is crucial in every patient to document or exclude mastocytosis by appropriate...

...I. Alvarez-Twose; D. González-de-Olano; L. Sánchez-Muñoz; A. Matito; M. Jara-Acevedo; C. Teodosio; A. García-Montero; J.M. Morgado; A. Orfao; L. Escribano Background: A variable percentage of patients with systemic mast cell (MC) activation symptoms meet criteria for systemic mastocytosis (SM). We...

...A. Matito; I. Álvarez-Twose; J.M. Morgado; L. Sánchez-Muñoz; A. Orfao; L. Escribano Background: The impact of pregnancy on mast cell (MC)-related symptoms and newborn outcome in women with mastocytosis is not well described. We report a series of 30 women who had 45 pregnancies. Methods: Patients...

...Hiroshi Nagata; Tadashi Okada; Alexandra S. Worobec; Tekli Semere; Dean D. Metcalfe The c-kit Asp816Val activating mutation is found in all patients with mastocytosis with an associated hematologic disorder, and at least in a subset of patients with indolent mastocytosis. The case of an 11-month...

...Lixin Li; Steven A. Krilis Human mast cells (MC) were derived from umbilical cord blood and bone marrow progenitors cultured in the presence of a conditioned medium from a human mastocytosis cell strain and recombinant human kit ligand (rhKL). KL induced MC of predominantly two immunophenotypes, MC...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Allergy Anaphylaxis Apoptosis Bcl-2 c- kit IgE antibody Mast-cell-defïcient mice Mast cells Mastocytosis Proto...

...Lixin Li; Janet J. Macpherson; Stephen Adelstein; Clive L. Bunn; K. Atkinson; K. Phadke; Steven A. Krilis Mature human mast cells were obtained from human bone marrow in a coculture system using conditioned medium from a human mastocytosis cell strain. These cells expressed the high-affinity IgE...

... allergic encephalomyelitis. All W/W v mice developed extensive dermatitis with mastocytosis at the injection sites about 4 months after inoculation. Mast cells were identified by light microscopy following staining with toluidine blue and berberine sulfate as well as electron microscopy. They were also...

...Joseph H. Butterfield; Catherine R. Weiler Background: Patients with systemic mastocytosis have increased numbers of mast cells in the bone marrow and other organs, such as the liver, spleen, gastrointestinal tract and skin. Symptoms result from the local and remote effects of mediator release from...

...N. Wagner; D. Fritze; B. Przybilla; M. Hagedorn; F. Ruëff We report on a 33-year-old female patient with indolent systemic mastocytosis and urticaria pigmentosa who died of an anaphylactic reaction after a yellow jacket sting. As she had no history of previous anaphylactic sting reaction...

...Karoline Sonneck; Stefan Florian; Leonhard Müllauer; Friedrich Wimazal; Manuela Födinger; Wolfgang R. Sperr; Peter Valent Background: Patients with mastocytosis may suffer from severe hypotension after wasp or bee stings. In these patients, no specific IgE is detectable, but they usually have skin...

...Nataliya M. Kushnir-Sukhov; Erica Brittain; James C. Reynolds; Cem Akin; Dean D. Metcalfe Background: Mastocytosis is associated with a pathological increase in tissue mast cells. Associated skeletal problems include a decrease in bone density and pathological fractures. Methods: In order...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. GATA-3 IgE Eosinophilia Mastocytosis Heligmosomoides polygyrus Th2 Induction of Th2 cells is a major event...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Apoptosis bcl-2,bcl-x L c-KIT Mastocytosis Differentiation, survival and death of hemopoietic cells are regulated by a complex network of factors. Depending on the type of cell and stage...

...Wolfgang R. Sperr; John-Hendrik Jordan; Michael Fiegl; Luis Escribano; Carmen Bellas; Stephan Dirnhofer; Hans Semper; Ingrid Simonitsch-Klupp; Hans-Peter Horny; Peter Valent Background: The serum tryptase level is used as a diagnostic marker in mastocytosis and is considered to reflect the burden...

...Cem Akin; Dean D. Metcalfe Measurement of surrogate mast cell-related products in blood or urine is often performed to assess disease extent in evaluating patients with mastocytosis. Serum tryptase and 24-hour urine histamine metabolites are the most commonly used surrogate markers of mastocytosis...

...Wolfgang R. Sperr; Hans-Peter Horny; Peter Valent Systemic mastocytosis (SM) is a myeloproliferative disease affecting multipotent and/or mast cell-committed hematopoietic progenitor cells. In a significant subgroup of patients (10–35%), an associated clonal hematologic non-mast cell lineage...