...Antti P. Kaukinen; Rauno J. Harvima; Ilkka T. Harvima Introduction: The cells of the immune system are thought to contribute to the development of skin cancers, such as basal cell carcinoma (BCC). One possible mechanism may be the interaction between mast cells and regulatory T cells (Tregs...

...Yuka Nagata; Ryo Suzuki Background: Allergen-specific desensitization of mast cell (MC) IgE receptors (FcεRI) is an important mechanism of allergen-specific immunotherapy that enables tolerance induction via systemic desensitization. Experimental in vitro IgE-mediated MC desensitization...

...Jenni Komulainen; Hanna Siiskonen; Ilkka T. Harvima Introduction: Mast cells and their major protein, the serine proteinase tryptase, can be involved in cutaneous photodamage and carcinogenesis. The serum test of tryptase (S-tryptase) measures total tryptase protein (active tryptase and inactive...

... cell Immunoglobulin E Mast cell Proteasome inhibitor National Institutes of Health (NIH) 10.13039/100000002 Since peanut allergy, often life-long, is mediated by immunoglobulin E (IgE), targeting plasma cells (PCs) as an approach to decrease IgE seems reasonable. Recent studies...

...Naruto Noma; Masataka Asagiri; Masatoshi Takeiri; Saori Ohmae; Kenji Takemoto; Keiko Iwaisako; Nagahiro Minato; Mari Maeda-Yamamoto; Siro Simizu; Kazuo Umezawa Background: Stimulation with antigen and IgE is known to activate NF-κB in mast cells. In the present research, we studied the role of NF...

...Arnold S. Kirshenbaum; Amy Petrik; Rosemary Walsh; Tara L. Kirby; Sury Vepa; Danny Wangsa; Thomas Ried; Dean D. Metcalfe Background: In 2003, this laboratory published an account of the human mast cell line LAD2 (Laboratory of Allergic Diseases 2) that expressed FcεRI, responded to recombinant...

...Rikiya Koketsu; Masao Yamaguchi; Maho Suzukawa; Yusuke Tanaka; Hiroyuki Tashimo; Hidenori Arai; Hiroyuki Nagase; Kenji Matsumoto; Hirohisa Saito; Chisei Ra; Kazuhiko Yamamoto; Ken Ohta Background: Basophils and mast cells are important initiator/effector cells capable of rapidly responding to IgE...

...Junichi Hosokawa; Kotaro Suzuki; Daiki Nakagomi; Tomohiro Tamachi; Hiroaki Takatori; Akira Suto; Hiroshi Nakajima Background: Mast cells are known to play a pivotal role in allergic diseases by releasing granules containing histamine and other preformed chemical mediators. Cross-linking of high...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2012 Emergency Food allergy Adrenaline Epinephrine Anaphylaxis Mast cell Tryptase Drug allergy Diagnosis of anaphylaxis is based on suggestive clinical...

...Rika Nakamura; Ryosuke Nakamura; Reiko Adachi; Yasuharu Itagaki; Yuma Fukutomi; Reiko Teshima Background: We performed an in vitro elicitation test to determine the ability of different types of wheat-allergic patients’ IgE to induce humanized mast cell activation after the addition of various time...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Allergy Mast cell Local IgE synthesis FcεRI Mast cells play a central role in the immediate-phase allergic...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Chondroitin sulphate B Cytokine expression Cytokine presentation Interferon-=γ Macrophage Mast cell Nitric...

...Hironori Sagara; Sohei Makino; Naomi Chibana; Mayumi Ota; Stephen T. Holgate; Martin K. Church; Takeshi Fukuda Inflammation of the airways is a cardinal feature of asthma. It has recently been recognized that mast cells may contribute to this process by cytokine secretion. Activation of a number...

...T. Zuberbier; A. Lelke; K. Sänger; P. Welker; S. Guhl; B.M. Henz References 1. Metcalfe DD, Baram D, Mekori YA: Mast cells. Phys Res 1997;77:1033–1079. 2. Welker P, Grabbe J, Gibbs B, Zuberbier T, Henz BM: Nerve growth factor-β induces mast-cell marker expression during in vitro culture...

...T.-J. Lin; T.B. Issekutz; Jean S. Marshall Background: Mast cell numbers and expression of chemokines are known to increase in the context of angiogenesis and inflammation, but the mechanisms by which this occurs are not understood. Stromal-derived factor-1 (SDF-1) is an important chemokine...

...Yukihiko Kitamura; Eiichi Morii; Hideki Ogihara; Tomoko Jippo; Akihiko Ito We have used various mouse mutants for studying the development of mast cells. The bone marrow origin of mast cells was shown by using giant granules of beige mice as a marker. Mast cell-deficient W/W v and Sl/Sl d mice...

...I. Alvarez-Twose; D. González-de-Olano; L. Sánchez-Muñoz; A. Matito; M. Jara-Acevedo; C. Teodosio; A. García-Montero; J.M. Morgado; A. Orfao; L. Escribano Background: A variable percentage of patients with systemic mast cell (MC) activation symptoms meet criteria for systemic mastocytosis (SM). We...

... months after primary immunization. Enhanced secretory responses to nerve stimulation, increased mucosal mast cell numbers, as well as elevated IgE titers were also induced and may have contributed to the overall responsiveness of the intestine to antigen challenge. Conclusions: Our findings indicate...

... of dexamethasone administered in drinking water to C57BL/6N mice infected with Cryptosporidium parvum. J Parasitol 1993;79:626–630. 13. Maurer M, Wedemeyer J, Metz M, Piliponsky AM, Weller K, Chatterjea D, Clouthier DE, Yanagisawa MM, Tsai M, Galli SJ: Mast cells promote homeostasis by limiting endothelin-1...

... are of pathophysiological importance which take much longer to be reversed. However, there might be currently unknown effects of omalizumab other than IgE capture, especially in regard to the inhibition of mast cell degranulation. Further research is necessary to clarify the mechanism of action of omalizumab in patients...