... to both pathogens and neighboring cells. It remains unclear how eosinophils can maintain control of the effects so that they themselves do not disintegrate from within. In the case of major basic protein (MBP), toxicity is regulated by functional aggregation and crystallization [ 31 ]; likewise, human ECP...

... type II pulmonary alveolar epithelial cells (A549) infected with RS virus and/or eosinophil granule proteins such as major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) were observed by microscopy. Apoptosis/necrosis...

.... Partial N-terminal amino acid sequence analysis revealed that the 18-kD protein and the 17-kD protein were homologous to the human eosinophil cationic protein (ECP) and the human and guinea pig major basic protein (MBP), respectively. Both the two proteins showed strong bactericidal activity against...

...) are present in eosinophil promyelocytes. In order to determine a possible relationship between the two granule subsets, immunoelectron-microscopic techniques were used to determine the presence and precise intragranular distribution of major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil...

...) and, at least in part, airway remodeling by releasing leukotrienes and highly basic and cytotoxic proteins such as major basic protein (MBP). However, a recent clinical trial using humanized anti-interleukin-5 monoclonal antibody found a failure to reduce AHR and the LAR, whereas the antibody entirely abolished...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Eosinophil Major basic protein...

..., and IL-5 in Iscove’s MEM, and proliferated until the 2nd week, when the cell number reached a plateau. Under these conditions, more than 90% of the cells differentiate into mature eosinophils in 3 weeks. The expression of major basic protein and eosinophil-derived neurotoxin in the treated cells...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Rat peritoneal mast cells Eosinophils Major basic protein Non–IgE–dependent activation Pertussis toxin Mast...

...Hirokazu Kubo; David A. Loegering; Cheryl R. Adolphson; Gerald J. Gleich Background: Eosinophil granule major basic protein (MBP) mediates many eosinophil–associated immune functions and it adheres eosinophils to parasite targets. Methods: We compared the toxicities of MBP and melittin to K562...

...Takeaki Nittoh; Mikito Hirakata; Suetsugu Mue; Kazuo Ohuchi We have determined the complete nucleotide sequence for cDNA of rat homologues of human eosinophil major basic protein (MBP) and eosinophil cationic protein (ECP) using the rapid amplification of cDNA ends (RACE) procedure. Nucleotide...