... on asthma patients. Additionally, tiotropium inhibits allergic airway inflammation and remodeling in a murine asthma model. However, the underlying mechanisms of this M3 receptor antagonist remain unclear. Therefore, we investigated the effect of muscarinic M3 receptor blockage on M2 macrophage development...

...Pier Giorgio Puzzovio; Bruce D. Levy; Francesca Levi-Schaffer Background: CD300a is an inhibitory receptor (IR) expressed on several leukocytes, including mast cells (MCs) and macrophages (MΦ), important cells in allergic inflammation (AI). We have previously characterized CD300a role on MCs...

... importance of macrophage in AS pathogenesis, we investigated the transcriptional profile of macrophage cells in the disease. Methods and Results: Two approaches of differential expression and subsequently, weighted gene co-expression network analysis was utilized to analyze a publicly available microarray...

...-19 SARS-CoV-2 Macrophages Y chromosome X chromosome Immunity Melatonin Edited by: H.-U. Simon, Bern. References 1. Klein   SL , Flanagan   KL . Sex differences in immune responses . Nat Rev Immunol . 2016 ; 16 ( 10 ): 626 – 38 . 10.1038/nri.2016.90 2...

... macrophage culture was used to determine their relationships with macrophages. Results: Immunohistochemistry revealed that the expressions of CCL21 and CCL25 were increased in NPs only. Western blotting revealed that these expressions were gradually increased in control, CRS without NP and CRS with NP groups...

... in both Foxp3+ regulatory T cells and IL-10-positive alveolar macrophages at the site of inflammation. Conclusions: This model recapitulates the key features of human asthma and may facilitate investigation into the mechanisms that promote immunological tolerance against clinically relevant aeroallergens...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Macrophages Mast cells, skin Histidine decarboxylase Tryptase...

... the function of inflammatory and immune cells. Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages. Methods: Macrophages purified (>95%) from lung...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Monocytes Macrophages T lymphocytes IL-12 CD40 ligand The effect was seen on the protein as well...

...Sean Deane; Carlo Selmi; Suzanne S. Teuber; M. Eric Gershwin Macrophage activation syndrome (MAS) is a phenomenon characterized by cytopenia, organ dysfunction, and coagulopathy associated with an inappropriate activation of macrophages. Current diagnostic criteria are imprecise, but the syndrome...

...Ronaldo A. Ribeiro; Marcus V.P. Souza-Filho; Marcellus H.L.P. Souza; Sandra H.P. Oliveira; Carlos H.S. Costa; Fernando Q. Cunha; Sergio H. Ferreira In the present study, we have investigated the participation of resident peritoneal cells (macrophages and mast cells) in the neutrophil migration...

...Sandra H.P. Oliveira; Lucia H. Faccioli; Fernando Q. Cunha; Sergio H. Ferreira Recently we demonstrated that the eosinophil migration into rat peritoneal cavities induced by a large volume of saline is mediated by LTB 4 released by the resident macrophages and mast cells. In the present study, we...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Anti-inflammatory Macrophages Glucocorticoids Oedema Clinical Features, Management and Pharmacology of Allergic...

...G. Zwadlo-Klarwasser; W. Hamann; P. Gatsios; L. Graeve; W. Schmutzler 4 9 2009 IL-6 receptor Monocytes Macrophages Subsets Northern blot 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

.... Alternatively, pure BeSO 4 was injected 2 days after a single application of cyclophosphamide (150 mg/kg). The spleen index, the spontaneous and phorbolmyristate acetate (PMA)-induced radical oxygen intermediates (ROI) released by peritoneal macrophages, and the proliferative activity of spleen mononuclear...

... the response. In the presence of saline, but not of PBS, mast cells and macrophages incubated in vitro released a factor which induced eosinophil migration when injected into the peritoneal cavity of rats. This release was inhibited by BW A4C and MK 886. These results indicate the importance of mast cells...

... afterwards, lung lavage cells produced more O –– 2 after PMA or OZ stimulation than did cells from unexposed guinea pigs. The pattern of O –– 2 generation by interstitial cells followed that of lung lavage macrophages. O –– 2 production remained unchanged in BMs at all times. These results suggest...

... fibroblasts and granulocyte-macrophage colony-stimulating factor were studied. In both cell types, lipid bodies were the predominant structures labeled with anti-PGH synthase. Labeling was absent in controls. In both human eosinophils and murine fibroblasts, lipid bodies represent sites of localization of PGH...

... augmented granuloma sizes, TNF-α and N-acetyl-β- D -glucos-aminidase levels of lung extracts in C3H/HeN, but not in C3H/HeJ mice. Granuloma macrophages of C3H/HeN mice produced higher levels of superoxide anion and TNF-α than those of C3H/HeJ mice. Taken together with our previous report that macrophages...

...Massimo Triggiani; Alfonso Oriente; Gennaro de Crescenzo; Gianni Marone The aim of this study was to define the lipid pools in which arachidonic acid (AA) is stored and from which it is released upon activation of human lung macrophages (HLM). HLM incorporate exogenous AA into neutral lipids...