... or presence of lysine-aspirin, eosinophils were stimulated with arachidonic acid or calcium ionophore to trigger the 15-lipoxygenase-1 (15-LO) and 5-lipoxygenase (5-LO) pathways, respectively. 15(S)-hydroxy-eicosatetraenoic acid (15-HETE) and eoxin C 4 (EXC 4 ) were measured as 15-LO products and leukotriene...

...Ramses Ilarraza; Yingqi Wu; Darryl J. Adamko Background: Leukotrienes are potent inflammatory mediators which modulate immune responses and induce bronchoconstriction in susceptible individuals. Montelukast (MK) is a leukotriene receptor (CysLT1) antagonist that has been shown to prevent...

... and leukotriene D 4 receptor antagonists in patients with chronic stable asthma. In this study we review the data demonstrating that chronic administration of zileuton, an inhibitor of 5-lipoxygenase, is associated with improved airway function, decreased asthma symptoms and decreased need for asthma medication...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Late asthmatic response Airway eosinophilia Airway hyperresponsiveness Thromboxane Leukotriene International Arrimes ni A llergyImmunology Kazuhiro Itoh Emi Takahashi Osamu...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Asthma Aspirin Leukotriene C 4 synthase IntvnulHHtil Vrchnes of Allergy...

...Hiroichi Nagai; Masahiko Kondo; Akihide Koda; Shin Nakamura; Michiko Hashimoto; Yukiyoshi Yanagihara; Michio Daikoku The responsiveness of isolated Japanese monkey ( Macaca fuscata ) tracheal muscle to antigen, carbachol, histamine, leukotriene C 4 (LTC 4 ), U-46619 and substance P (SP...

...Y. Sakuma; S. Katayama; H. Tsunoda; S. Abe; I. Yamatsu; K. Katayama Fundamental studies were conducted to examine the release of histamine and leukotriene (LT) C 4 from lung fragments of guinea pigs and the effects of E6080 on the release of LTB 4 and LTC 4 from lung fragments or inflammatory cells...

... mouse bone marrow-derived mast cells were transferred. Results: Pam3CSK4 and Bifidobacterium pseudocatenulatum JCM 7041 suppressed degranulation of IgE-sensitized mast cells upon antigen stimulation in vitro. Pam3CSK4 also suppressed leukotriene C 4 production triggered by engagement of the high...

...Takashi Ichiyama; Masanari Hasegawa; Kunio Hashimoto; Takeshi Matsushige; Reiji Hirano; Susumu Furukawa Background: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are known for their chemotactic and proinflammatory effects on monocytes/macrophages which have a cysteinyl leukotriene 1 (CysLT...

... asthmatic response (DAR). During DAR, both albumin leakage and fucose secretion into the bronchoalveolar lavage fluid were increased. The cysteinyl leukotriene antagonist pranlukast failed to inhibit either EAR or DAR while the corticosteroid dexamethasone significantly suppressed DAR, without significantly...

...Makoto Nagata; Keiko Saito; Izumi Kikuchi; Koichi Hagiwara; Minoru Kanazawa Background: Evidence shows that leukotriene receptor antagonist (LTRA) can cause a partial reduction of eosinophils in the asthmatic airway. Although cysteinyl leukotrienes (CysLTs) can regulate the development...

... in chronic allergic disease remain to be elucidated. The unusual ability of Toll-like receptor 2 activators to selectively induce leukotriene production by mast cells opens up new possibilities concerning mechanisms of disease exacerbation during infection. One of the functionally more complex TLRs is TLR2...

... Leukotriene Montelukast Safety Seasonal allergic rhinitis Seasonal allergic rhinitis (SAR) and asthma are often comorbid conditions. Epidemiologic studies suggest that up to 78% of patients with asthma have SAR and more than one third of patients with SAR have asthma [ 1, 2 ]. Either...

.... In this study we assessed the cytokine profile present in chronic urticaria sera, and then measured cytokine and leukotriene release from basophils and mast cells upon incubation with chronic urticaria sera. Finally we assessed cytokine expression at the single-cell level and characterized the T cell...

..., and to investigate whether this protective activity is associated with reduction in aspirin–induced excretion of urinary leukotriene E 4 (u–LTE 4 ), a marker of the cysteinyl LT overproduction that participates in the pathogenesis of aspirin–induced asthma. We assessed the effects of pretreatment with cromolyn...