...E. Castigli; R. Fuleihan; N. Ramesh; E. Tsitsikov; A. Tsytsykova; R.S. Geha CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response...

...Jean-Yves Bonnefoy; Jean-François Gauchat; Paul Life; Pierre Graber; Jean-Pierre Aubry; Sybille Lecoanet-Henchoz At least two cell-derived signals have been shown to be necessary for the induction of immunoglobulin isotype switching in B cells. The first signal is given by either of the soluble...

..., Zhang K, Saxon A: IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: switching to γ1, γ3, and γ4, but not γ2. J Immunol 1995;155:2318–2328. 41. Sideras P, Mizuta T-R, Kanamori H, Suzuki N, Okamoto M, Kuze K, Ohno H, Doi S, Fukuhara S, Hassan MS, Hammarström...

... remained unexplored. We address this issue starting with the IL–4–dependent induction of γ4 germline transcription, an essential step in the commitment to isotype switching. Results: γ4 germline transcripts were cloned and shown to contain Iγ4 spliced to the 5′ portion of Cγ4 using the splice donor site...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. IgE Isotype switching Interleukin-4 Interleukin-13 Review Int Arch Allergy Immunol 1998;115:257 269 Leonard B. Bacharier Haifa Jabara Raif S. Geha Division...