...Yanchun Li; Hongbo Wang; Honghua Lu; Shucheng Hua Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells...

... asthma phenotypes have opened up new therapeutic avenues for asthma treatment. The approval of the humanized anti-IgE antibody omalizumab for the treatment of severe allergic asthma has paved the way for other cytokine-targeting therapies, particularly those targeting interleukin (IL)-4, IL-5, IL-9, IL...

... remain not controlled. Certainly, adherence to therapy and the education of patients remain the primary objective, but the increasingly detailed knowledge about the pathogenic mechanisms and new biotechnologies offer the opportunity to better address and treat the disease. Interleukin (IL)-13 and IL-4...

... bovine serum (FBS) in the presence of FF (from 10 -12 to 10 -7 M ) for 6-24 h. Cytokine [granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-8] concentrations in supernatants were measured by ELISA. Peripheral blood eosinophils were incubated for 4 days with epithelial...

...D.Z. Staynov; D.J. Cousins; T.H. Lee We have recently found a novel conserved motif in the promoters of several T-cell-expressed cytokines [human interleukin-2, -4, -5 and -13 and human and mouse granulocyte/macrophage-colony stimulating factor (GM-CSF)]. It contains a core sequence CTTGG...CCAAG...

..., instructions or products referred to in the content or advertisements. Basophils Interleukins Chemokines Complement Th2 4 9 2009 Inlcnutkinal Archives of AllergyImmunology III. C ytokin e s, IgE P ro d u c tio n and M a st Cell A c tiva tio n Int Arch Allergy Immunol 1997;! 13:134-137...

... have attempted to review the respective roles of interleukins 1, 2, 4, 6, and 7. Special emphasis was given to interleukin 7 which has been shown to play a key role in early T cell differentiation. 3 9 2009 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright...

...Wei He; Dieter Kabelitz Highly purified CD4 –– 8 –– double-negative (DN) human thymocytes proliferated significantly more in response to interleukin (IL)-7 than to IL-2 in a dose-dependent fashion. Both IL-7 and IL-2 promoted the appearance of T-cell receptor (TCR) γδ-expressing cells in single...

...Tomomi Hashimoto; Noriaki Kobayashi; Yuichiro Kajiyama; Osamu Kaminuma; Matsunobu Suko; Akio Mori Background: Interleukin (IL)-5 and IL-13 are important cytokines in allergic diseases such as asthma and atopic dermatitis. We have reported that the production of IL-5 and IL-13 by mite-responsive T...

..., rather than absolute changes in cytokine levels. Little is known about SCR in intermittent allergic rhinitis (IAR). Objective: To examine the concentrations of SCR, i.e. sIL-1R2, sIL-4R, sIL-6R and sTNFR1, as well as the interleukin-1 receptor antagonist (IL-1Ra) in nasal fluids from allergen-challenged...

...Nobuhiro Matsumoto; Shigeki Katoh; Hiroshi Mukae; Takeshi Matsuo; Kiyoshi Takatsu; Shigeru Matsukura Infiltration of antigen-specific CD4+ T cells and production of interleukin (IL)-5 in inflammatory regions play a central role in antigen-induced pulmonary eosinophilia. Genetically IL-5-deficient...