...Yoshito Matsuo; Shiro Sugiura; Seiya Masukane; Fumi Tanaka; Atsushi Makino; Katsumasa Kitamura; Teruaki Matsui; Yoshihiro Takasato; Komei Ito Introduction: We previously reported the result of slow low-dose oral immunotherapy (SLOIT), which is a 1-year severity-stratified low-dose OIT for severe...

...Haoyang Hu; Qiao-Zhi Qin; Wei Zheng; Zhi-Qiang Xu; Xiang Chen Introduction: House dust mite is the primary trigger of allergic respiratory diseases worldwide, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in the clinic. The use of allergen molecules instead...

...Yongcai Gao; Lingli Zhou; Qiong Su; Qiang Li Introduction: Major histocompatibility complex class II molecule (MHC-II) is pivotal in anti-tumor immunity, and targeting MHC-II in tumors may help improve patient survival. But function of MHC-II in the immunotherapy and prognosis of lung...

...Ariadna Soto; Matías Perrone Sibilia; Vanesa Roxana Sánchez; Nadia Arcón; Valentina Martin; Ignacio Martín Fenoy; Alejandra Goldman Background: We have previously showed rTgPI-1 tolerogenic adjuvant properties in asthma treatment, turning it a promising candidate for allergen-specific immunotherapy...

...Ana I. Tabar; Julio Delgado; Eloina González-Mancebo; Esozia Arroabarren; Lorena Soto Retes; Javier Domínguez-Ortega; Spanish Allergy and Clinical Immunology Scientific Society (SEAIC) The Global Initiative for Asthma Report updated in 2019 stated that potential benefits of allergen immunotherapy...

...Juan María Beitia; Arantza Vega Castro; Remedios Cárdenas; Maria Isabel Peña-Arellano Background: Lipid transfer proteins (LTPs) syndrome is an important cause of multiple plant food allergy in the Mediterranean area. The effectiveness of sublingual immunotherapy (SLIT) with the LTP Pru p 3 extract...

...Paula Kranert; Stephan Forchhammer; Sebastian Volc; Franziska Stenger; Martin Schaller; Jörg Fischer Background: Venom immunotherapy (VIT) is an established and effective treatment for patients with Hymenoptera venom allergies. Especially during the build-up of VIT, systemic allergic reactions...

.... A study aiming to investigate the early effects of subcutaneous immunotherapy with house dust mite allergen revealed cycles of expansion and contraction of Tregs and IgE+ B cells that occur with each subcutaneous immunotherapy injection, while the percentages of CD4+ and CD8+ T cells, NK cells, total B...

...Nada Chaoul; Marcello Albanesi; Lucia Giliberti; Maria Pia Rossi; Eustachio Nettis; Danilo Di Bona; Maria Filomena Caiaffa; Luigi Macchia Background: Subcutaneous immunotherapy (SCIT) is an effective treatment of respiratory allergies including house dust mite (HDM) and Hymenoptera venom allergy...

.... Pharmacotherapy is the most common treatment for ragweed pollen allergy but fails to impact on the course of allergy. Allergen-specific immunotherapy (AIT) is the only causative and disease-modifying treatment of allergy with long-lasting effects, but currently it is based on the administration of ragweed pollen...

...Kalliopi Kontou-Fili; Constantinos Pitsios; Evangelia Kompoti; Dionysios Giannakopoulos; Spyros Kouridakis Background: The long-term protection provided by venom immunotherapy (VIT) is related to the dose administered and to its long duration; the latter, however, becomes inconvenient for patients...

... in case of accidental exposure, which negatively affects patients' quality of life, so new treatments are highly desirable. Different food immunotherapy modalities have recently been used, with variable success rates in the induction of desensitization and tolerance, and different numbers and types...

...Noriyuki Yanagida; Sakura Sato; Tomoyuki Asaumi; Kenichi Nagakura; Kiyotake Ogura; Motohiro Ebisawa Background: The minimal dose for oral immunotherapy (OIT) tolerance is unknown. We investigated the efficacy and safety of low-dose OIT with 1/32 of the volume of a whole egg. Methods: Thirty-three...

...Jean Sainte-Laudy; François Touraine; Delphine Cluzan; François Belle Moudourou Background: A major problem of venom-specific immunotherapy (VIT) is the absence of reliable parameters for deciding treatment discontinuation. Aim of the Study: Intracutaneous tests (ICTs), the basophil activation test...

... ]. Altered peptide ligand Peptides T cells T cell epitopes T cell activation T cell responses Immunotherapy The mechanisms that account for these differential effects have been thoroughly analyzed in the past but are not yet fully clear as of today. The first model proposed for the mode of action...

...Helene Henmar; Sofie Marie Toft Frisenette; Karin Grosch; Kim Nielsen; Gary Smith; Susanne Sønderkær; Jørgen Nedergaard Larsen Background: The production of house dust mite (HDM) allergen products for allergy immunotherapy has traditionally been based on purified mite bodies or whole-mite culture...

...Claus Bachert; Jakob Noergaard Andreasen Pharmacotherapy is widely used to manage allergic rhinitis (AR), but often does not adequately control symptoms. Allergy immunotherapy (AIT) should be considered for patients who are not adequately controlled on symptomatic treatment. AIT is gaining...

...Alain Didier; Paloma Campo; Francisco Moreno; François Durand-Perdriel; Alicia Marin; Antoine Chartier Background: House dust mite (HDM) immunotherapy has proven efficacy in treating allergic rhinitis (AR) symptoms. This trial evaluated the dose-response relationship of SLITone ULTRA ® HDM mix...

...Noriyuki Yanagida; Sakura Sato; Tomoyuki Asaumi; Yu Okada; Kiyotake Ogura; Motohiro Ebisawa Background: This study aimed to investigate the efficacy and safety of low-dose-induction oral immunotherapy (OIT) with 3 ml of milk, which is a lower target volume than is conventionally used. Methods...

... Stahl-Skov; George Stavroulakis; Georg Stegfellner; Sonia Vázquez-Cortés; Marianne Witten; Frank Stolz; Lars K. Poulsen; Montserrat Fernandez-Rivas; Rudolf Valenta; Ronald van Ree Background: The FAST (food allergy-specific immunotherapy) project aims at developing safe and effective subcutaneous...