... of IL-5 and IL-13, and suppressed the production of the eicosanoid 12-HETE by mediastinal lymph node cells. Conclusions: These data show that during aeroallergen challenge, estrogen stimulates Th2 cytokine production, which may be linked to its ability to suppress 12-HETE. Lung resistance at baseline...

... are responsible for creating late asthmatic responses and airway hyperresponsiveness. The simulated results for the anti-IL-5 therapy indicate that eosinophils are not the sole contributors to the late-phase airway obstruction in asthma. This prediction is consistent with recently reported results from an anti-IL...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Eosinophils IL-5 Th2 cell Ten nonsmoking patients with CVA who were suffering from a chronic nonproductive...

...N. Yawalkar; W.J. Pichler Background: In vitro data derived from drug-specific T cell clones have revealed that heterogeneous T cell subsets with distinct phenotypes (CD4+ > CD8+) and cell functions (strong IL-5 production, cytotoxic potential) are generated. The aim of this study...

... of systemic corticosteroids on these responses between rhinovirus and RS virus groups. Results: The serum levels of ECP, IL-5, and IL-6 were significantly elevated in patients with rhinovirus-induced acute exacerbation of asthma compared with controls, while serum IL-1β and IFN-γ were significantly lower...

..., eotaxin, RANTES, PDGF-bb, FGF basic and VEGF) using a multiplex bead-based assay in 85 acute and 79 stable asthma patients, and 14 controls. We also examined the effects of systemic corticosteroids on these responses in acute asthma. Results: The serum levels of ECP, IL-5, -6, -8 and -10, G-CSF, MCP-1, IL...

...Yuvadee Mahakunkijcharoen; Yoshio Osada; Takeshi Nara; Toru Horie; Kiyoshi Takatsu; Somei Kojima Eosinophils from interleukin (IL)-5 transgenic mice were shown to have antibody-dependent killing activity against the larvae of Schistosoma japonicum . However, in comparison with rat eosinophils...

...Takao Fujisawa; Akihiko Terada; Jun Atsuta; Kosei Iguchi; Hitoshi Kamiya; Minoru Sakurai The ability of IL-5 to induce eosinophil degranulation was investigated. Peripheral blood eosinophils from patients with mildly allergic individuals were isolated with CD 16- selection method. Eosinophils were...

...Osamu Kaminuma; Akio Mori; Matsunobu Suko; Hideo Kikkawa; Kazuaki Naito; Hirokazu Okudaira To delineate the critical role of T cells on asthma, we tested whether eosinophilic inflammation of the bronchial mucosa is induced by transfer of IL-5-producing T cell clones, in the absence of antigen...

... current interest. We have shown that eosinophils infiltrating the site of human cutaneous late-phase reactions (LPR) express mRNA and protein product for IL-4 and IL-5. Stimulation of peripheral blood eosinophils in vitro with either IgG or slgA produces time-dependent induction of IL-4 and IL-5...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Asthma CD8 Cytokines HMC-1 IFN-γ IL-4 IL-5 Mast cells T...

... colony assays or by flow cytometric analyses of CD34+, IL-3Rα+, and/or IL-5-responsive cell populations. In dogs, but not in humans, a transferrable serum hematopoietic activity accounts for the marrow response to inhaled allergen. These findings suggest that allergen-induced increases in bone marrow...

...Hiroshi Tachimoto; Motohiro Ebisawa; Yoji Iikura; Masahiro Kimata; Kazuhiko Mori; Naoya Sakaguchi; Akira Akasawa; Toshiharu Nakajima; Hirohisa Saito Mast cells Eosinophils GM-CSF IL-5 Late phase allergic reaction 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

.... They were found to stimulate CD4+ and CD8+ T cells in vitro, and some reactive T cell lines were oligoclonal. The majority of lidocaine-specific clones secreted rather high amounts of IL-5 and IL-4 after PMA/ionomycin stimulations (Th2-like), but some CD4+ and all CD8+ clones had a Th1-like phenotype (high...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. IL-5 Gene transcription Promoter T cell Inu-malKMul Archives of Allergy Immunology Hirokazu Okudaira Akio Mori...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. IL-5 Gene transcription Promoter T cell NF-AT International Archives...

...Masamichi Koike; Kiyoshi Takatsu IL-5 is a homodimeric glycoprotein that promotes proliferation and differentiation of activated B cells, and controls the production and functions of some other hematopoietic cells, such as Ly-1(CD5) + B cells, eosinophils and basophils. In humans, IL-5 acts...

... zymosan- or interleukin-5 (IL-5)-induced CLs. The CL values induced by these two stimuli appeared to be directly correlated with the intensity of each ligand-linked receptor expression. These results suggested that FcγRII- and/or IL-5R-mediated eosinophil activation at the site of lesional skins might...

...Hiroko Saito; Koji Asakura; Akikatsu Kataura An immunohistological study was performed on allergic and nonallergic nasal mucosa to examine interleukin-5 (IL-5) expression. Many cells in the superficial portion of lamina propria expressed IL-5 in allergic nasal mucosa, whereas few cells expressed IL...

...Mika Ueno; Kazuyoshi Watanabe; Susumu Tsurufuji; Mitsuomi Hirashima Differentiation of an eosinophilic cell line, YY-1, was induced by treatment with 0.3 m M butyric acid (BA). The effects of eosinophilotropic cytokines, such as IL-3, IL·5, and GM-CSF on BA-induced differentiation, especially...