...Sylvia M. Furst; Jay Gandolfi Background: The purpose of this study was to investigate lymphocyte adhesion to Kupffer cells as a component of an immune-mediated mechanism for halothane hepatitis. Methods: Kupffer cells were isolated from guinea pigs exposed to 1.0% halothane/40% oxygen and cultured...

...J.B. Clarke; C. Thomas; M. Chen; K.L. Hastings; A.J. Gandolfi Two halogenated anesthetics, enflurane and isoflurane, have been associated with an allergic-type hepatic injury both alone and following previous exposure to halothane. Halothane hepatitis appears to involve an aberrant immune response...