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Keywords: HIGMX-1
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Journal Articles
CD40 Ligand/CD40 Deficiency
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1995) 107 (1-3): 37–39.
Published Online: 04 September 2009
... to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgA and IgE. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond normally to T-independent antigens. 4 9...
