... fibrogenicity of mast cells and eosinophils in fibrosis with different etiopathologies and in the one resulting from some allergic conditions are increasing. Both these cells produce NGF and their functions are modulated by this factor. However, the direct effects of NGF on fibroblasts, which represent the main...

... diseases in the respiratory tract. Thymus- and activation-regulated chemokine (TARC) recruits Th2 cells to sites of inflammation. Resident fibroblasts are thought to contribute to inflammatory cell infiltration through chemokine production. We compared the abilities of nasal, bronchiolar and lung...

...Pia Welker; Jürgen Grabbe; Beate M. Czarnetzki Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT...

...Howard R. Katz; Robert B. Lobell Activation of mast cells for the release of secretory granule, membrane lipid, and cytokine mediators via FcγR requires cell surface expression of FcγRIII. A soluble factor(s) from fibroblasts up-regulates the surface expression of FcγRIII in interleukin-3-dependent...

...M. Paulmichl; A.A. Norris; D.K. Rainey Chloride channels Nedocromile sodium Sodium cromoglycate Fibroblasts 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

...Arnold S. Kirshenbaum; Julie P. Goff; John P. Albert; Steven W. Kessler; Dean D. Metcalfe To determine the fate of Fc ε RI+ cells on fibroblasts in vitro, human bone marrow derived CD34+ cells were cultured in the presence of recombinant human interleukin 3 and recombinant human hematopoietic stem...

...Francesca Levi-Schaffer; Varda Segal; Arnon Nagler Mast cells (MC)-fibroblast interactions may have a role in chronic inflammation and fibrotic processes. Chronic graft-vs.-host disease (cGVHD) is an autoimmune-like process mediated by immunocompetent T cells resulting in sclerodermoid, fibrotic...

...P. Welker; J. Grabbe; J. Hakimi; A.F. Walls; H. Ostmeier; B.M. Czarnetzki Mast cell differentiation markers were studied by culturing monocytic (U937, THP1) a promyelotic (HL60) and a human mast cell line (HMC1) and peripheral human blood monocytes with fibroblast supernatants and feeder layers...

...Ann M. Dvorak; Takuma Furitsu; Teruko Ishizaka The ontogeny of human mast cells (HMCs) is not known, but agranular precursors committed to HMC development are present in cord blood mononuclear cells. Individual cord bloods were cocultured with murine fibroblasts and prepared for light microscopy...

... to not only Th2 cytokines but also bacterial products such as lipopolysaccharides (LPS). A CC chemokine, TARC, is a potent chemoattractant for Th2 cells. The objectives of this study were twofold. First, we examined whether nasal polyp fibroblasts were able to produce TARC when costimulated with LPS and IL-4...

... of these allergic reactions. We postulated that dermal tissue might be a site of drug activation by cytochrome P450 (CYP) isozymes. Methods: Messenger RNA was extracted from cultured Langerhans cells, keratinocytes, fibroblasts and melanocytes from 6 individuals, and CYP mRNA expression was analyzed by RT-PCR...

...Manabu Nonaka; Ruby Pawankar; Fusako Saji; Toshiaki Yagi Eosinophil infiltration of tissue is a hallmark of nasal polyposis and asthma in both atopic and nonatopic patients. Structural cells like airway fibroblasts are a rich source of cytokines and inflammatory mediators. In order to verify...

... a profound effect of NGF on human fibroblasts and extracellular matrix. Conclusion: Data presented suggest that NGF is an important molecule in allergic inflammation and tissue remodelling occurring in allergic diseases. 23 4 1999 1999 Copyright / Drug Dosage / Disclaimer Copyright: All...