... on fibroblast activation in the pathogenesis of AD-like symptoms. Results: Topical use of cIY8 and oral use of glycyrrhizin significantly improved the MC903-induced AD-like symptoms and pathological changes of the ears and scratching behavior in an AD mouse model; cIY8 treatment inhibited the higher mRNAs of IL...

... = 0.0003) and the dermis ( p = 0.0154) as compared to NS. Cells expressing IL-15 were mainly keratinocytes, CD1a + DC, CD11b + DC, CD68 + macrophages, and vimentin + fibroblasts. In AD, an increase in the relative numbers of IL-15 expressing CD1a + DC, macrophages, and fibroblasts was noted. Conclusion...

... of hypoxia-induced remodeling. The aims of this study were to determine in hypoxia-stimulated nasal polyp-derived fibroblasts (NPDF) the effect of hypoxia on the differentiation of myofibroblasts, the role of ROS, the major Nox homolog mediating myofibroblast differentiation, and the role of TGF-β 1...

... were sacrificed and their lung tissues were obtained. Mouse lung fibroblasts were cultured and treated with IL-33 or IL-13. Results: The levels of IL-33 mRNA and IL-33 protein in lung tissue increased after the OVA challenge. Most IL-33-expressing cells were CD11c+ cells and epithelial cells, and many...

...Rebecca S. Bahn A controversy exists concerning whether the extraocular muscle cell or the fibroblast is the autoimmune target in Graves’ ophthalmopathy (GO). Although the extraocular muscle bodies are grossly enlarged in GO, the muscle cells themselves are histologically intact. Within the muscle...

..., line 200/206 chickens develop mononuclear cell (MNC) infiltrates in the skin, followed by severe dermal fibrosis and vascular occlusions. Cultured fibroblasts derived from fibrotic skin lesions of line 200/206 chickens display an activated phenotype producing elevated quantities of collagen...

...S. Oddera; F. Cagnoni; S. Mangraviti; J. Giron-Michel; O. Popova; G.W. Canonica Background: Lung fibroblasts may have a pivotal role in airway inflammation as they are involved in continuous cycles of mediator secretion, proliferation, activation and cross-talk with recruited inflammatory cells...

... and in the immune systems of the skin. To address this question, we have analyzed the regulatory mechanisms of autocrine induction of substance P (SP) by cultured normal human fibroblasts that compose the major population of the skin and might augment stress-induced skin inflammatory responses. In nonstimulated...

...). The highest dose of mizolastine (6 × 10 –6 M ), corresponding to 10-fold the peak plasma level after a single oral administration of 10 mg, was able to act on fibroblasts, significantly downregulating the expression of CD54 (p < 0.05). Regarding T lymphocyte proliferation, the addition of mizolastine did...

... of eotaxin generation by Th1-/Th2-derived cytokines in vitro. Methods: Human dermal fibroblasts, human umbilical vein endothelial cells and A549 human bronchial epithelial cell line cells were stimulated with TNF-α, IL-4, IFN-γ or TNF-α in combination with IL-4 or IFN-γ and the amount of eotaxin production...

... that dermal fibroblasts actively participate in the accumulation of Eo in Th2-mediated skin inflammation. Following stimulation with IL-4, dermal fibroblasts produce eotaxin, which is the only biologically active Eo attractant detected in the supernatants. Natural eotaxin is comprised of a mixture of N...

...Shigeru Takafuji; Shunsuke Shoji; Koji Ito; Kazuhiko Yamamoto; Takemasa Nakagawa Background: Although eosinophils (Eos) and fibroblasts (Fb) are closely approximated in the bronchial submucosae of asthmatics, and are believed to play important roles in the pathogenesis of bronchial asthma...