...Breanne N. Steffan; Elizabeth A. Townsend; Loren C. Denlinger; Mats W. Johansson Background: Eosinophils have numerous roles in type 2 inflammation depending on their activation states in the blood and airway or after encounter with inflammatory mediators. Airway epithelial cells have a sentinel...

...Vanessa Sofia Salvador Nunes; Alex Straumann; Luis Salvador Nunes; Alain M. Schoepfer; Thomas Greuter Having long been considered the mainstay in eosinophilic esophagitis (EoE) diagnosis and pathogenesis, the role of eosinophils has been questioned and might be less important than previously...

...% (45/84) of the NIP patients but not in control subjects. TLOs were composed of T cells, B cells, follicular dendritic cells, macrophages, and natural killer cells. Compared to NIP tissues without TLOs, tissues with TLOs showed significantly higher eosinophil infiltration levels (3.5-fold), elevation...

...; Marija Hadji Mitrova; Konstantinos Glynos; Katerina M. Antoniou; Mina Gaga; Nikolaos Tzanakis; Katerina Markopoulou; Despoina Papakosta; Petros Bakakos; Stelios Loukides Introduction: Mepolizumab is a monoclonal antibody against IL-5 for the treatment of severe eosinophilic asthma. The aim of the current...

...Hans-Uwe Simon; Shida Yousefi; Nina Germic; Isabelle C. Arnold; Angela Haczku; Alexander V. Karaulov; Dagmar Simon; Helene F. Rosenberg Eosinophils and their secretory mediators play an important role in the pathogenesis of infectious and inflammatory disorders. Although eosinophils are largely...

...Bradford A. Youngblood; Emily C. Brock; John Leung; Rustom Falahati; Paul J. Bryce; Jessica Bright; Jason Williams; Leonard D. Shultz; Dale L. Greiner; Michael A. Brehm; Christopher Bebbington; Nenad Tomasevic Introduction: Pathologic accumulation and activation of mast cells and eosinophils...

... exacerbated in SCD mice when they are exposed to the human allergen, house dust mite (HDM). Methods and Results: Eosinophil counts in bronchoalveolar lavage fluid were determined by cytocentrifugation and increased in both wild-type (WT) and SCD mice after acute exposure to a high dose (25 µg) of HDM, which...

... responses may be involved in these processes. Since eosinophils express pattern recognition receptors, HDM may directly upregulate eosinophil functions through these re ceptors. The objective of this study was to examine whether Dermatophagoides farinae ( Df ), a representative HDM, or Der f 1, a major...

...Kazuyuki Nakagome; Yutaka Nakamura; Takehito Kobayashi; Shoichiro Ohta; Junya Ono; Kiyoko Kobayashi; Kenji Ikebuchi; Toru Noguchi; Tomoyuki Soma; Kohei Yamauchi; Kenji Izuhara; Makoto Nagata Background: Eosinophilic pneumonia (EP) is characterized by massive pulmonary infiltration by eosinophils...

...Lin Lin; Zheng Chen; Xinyue Tang; Fei Dai; Jinjin Wei; Guangbin Sun Background: 5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is a potent eosinophil chemoattractant and activator that is synthesized not only in inflammatory cells but also in bronchial epithelial cells. The purpose of this study...

... airway hyperresponsiveness in allergic asthma. A number of inflammatory cells produce IL-33 and eosinophils express ST2 mRNA. The relationship between IL-33 and eosinophils in allergic asthma, however, remains unclear. Objective: The aim of this work was to evaluate in vitro the effect of allergen...

... between clinical data and ILC2 levels. It was found that asthma patients and asthma with AR patients had higher ILC2 levels compared to healthy subjects. ILC2s were positively correlated with the percentage of eosinophils in patients with asthma and AR, but not with pulmonary function. ILC2 levels were...

...-treated group ( n = 50), and a resveratrol-treated group ( n = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were...

...Caroline Ethier; Yingqi Yu; Lisa Cameron; Paige Lacy; Francis Davoine Background: Asthma severity and eosinophilia correlate with a deficiency in vitamin D and its active metabolite calcitriol. Calcitriol modulates numerous leukocyte functions, but its effect on eosinophils is not fully understood...

... that IL-25 plasma levels and IL-25 receptor (IL-25R: IL-17RA, IL-17RB, and IL-17RA/RB) expression on mature blood eosinophils are increased in atopic asthmatics compared to normal nonatopic controls. This study investigated allergen-induced changes in IL-25 and IL-25R expression in eosinophils from...

...Hae-Sim Park; Mi-Kyeong Kim; Nobuyuki Imai; Tsutomu Nakanishi; Mitsuru Adachi; Ken Ohta; Yuji Tohda; on behalf of the Asian Benralizumab Study Group Background: Airway eosinophils are considered to play an important role in the pathogenesis of asthma. Interleukin-5 is believed to be a key cytokine...

...Bernhard Kratzer; Winfried F. Pickl This review highlights the recent key advances in the biology of CD4 + effector T cells, antigen-presenting cells, Th17 and T regulatory cells, as well as immediate effector cells, such as mast cells, basophils and eosinophils, which are critically contributing...

...Taizo Wada; Yusuke Matsuda; Tomoko Toma; Eiko Koizumi; Hiroyuki Okamoto; Akihiro Yachie Background: Food protein-induced enterocolitis syndrome (FPIES) is an uncommon, non-IgE-mediated food allergy. We recently described a significant increase in fecal eosinophil-derived neurotoxin (EDN) after...

... increasing support. The study of eosinophils in induced sputum has proved useful for the diagnosis of asthma; however, its clinical implementation is complex. Some studies have shown that the measurement of exhaled nitric oxide (FeNO) may also be useful to establish disease phenotypes and improve control...

... young and adult OA rats. In young animals, thickening of the adventitia played a more crucial role in this increase than it did in adults, in which the mucosa and the submucosa participated to a higher degree. The IA walls of young OA rats had significantly higher levels of infiltrating eosinophils than...