... (65.85%) than in patients without asthma (9.17%). With regard to specific airway function indicators, age and a patient’s blood eosinophil (%) were identified as independent risk factors for lower FEF 50% %pred and FEF 25–75% pred, with age being an independent risk factor for FEF 75% %pred in asthmatic...

...Ling Ma; Yunping Deng; Kanghua Wang; Jianbo Shi; Yueqi Sun Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNPs) in China is characterized by a mixed eosinophilic-neutrophilic inflammation, linking to a more heterogeneous clinical phenotype. However, the relationship between eosinophilic...

... and detected SERPINB10 levels in induced sputum by ELISA and analyzed the correlation between SERPINB10 expression levels and FeNO, eosinophils in peripheral blood, lung function, and Th2 cytokines (IL-4, IL-5, and IL-13). Results: The levels of SERPINB10 in induced sputum in asthmatic patients were higher...

... = 0.026), eosinophil count (median = 190 [0–800] [cells/µL], p < 0.001), basophil count (median = 40 [0–100] [cells/µL], p = 0.021), and total IgE (median = 240.5 [45–2,644] [kU/L], p < 0.001) level were significantly higher in the omalizumab responder patients (UCT score ≥12 at 6 months...

...Jinbo Han; Weiqing Wang; Zhenzhen Zhu; Lei Wang; Yujie Chen; Ruiqi Wang; Kai Guan; Wei Lv Introduction: Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) exhibits a poorer prognosis than noneCRSwNP. The aim of this study was to analyze the potential of total immunoglobulin E (tIgE...

...Yara Zoabi; Fidan Rahimli Alekberli; Yael Minai-Fleminger; Ron Eliashar; Francesca Levi-Schaffer Introduction: The pathogenesis of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNPs) is not yet completely understood. Based on current knowledge, the infiltration of mast cells and eosinophils...

... with different CLC concentrations. Results: Sixty-eight (62.96%) patients developed recurrence during a 12- to 33-month postoperative follow-up. CLC concentrations in nasal secretions were positively correlated with eosinophil percent in polyp tissue and peripheral blood and were significantly higher in patients...

...Jiayi Yang; Jinjin Fan; Li Fan; Chunyan Yi; Jianxiong Lin; Haiping Mao; Xiao Yang; Xin Wang Introduction: Eosinophilia (eosinophil fraction of leukocytes >5%), an indicative parameter for bioincompatibility in various circumstances, is well established in hemodialysis. However, change...

...Hao Lv; Pei-Qiang Liu; Rong Xiang; Wei Zhang; Shi-Ming Chen; Yong-Gang Kong; Yu Xu Background: A hallmark of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is mucosal eosinophil-predominant inflammation. Nasal nitric oxide (nNO) is a known biomarker of eosinophilic inflammation...

...-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology. hans-uwe.simon@pki.unibe.ch 8 06 2020 8...

.... Secondary objectives included the effects of AZD1981 on prostaglandin D 2 (PGD 2 )-induced eosinophil shape change, circulating leukocyte subsets, CRTh2 expression on blood leukocytes, and total blood leukocyte histamine content. Results: Twenty-eight subjects were randomized to AZD1981 or placebo, with 26...

...Mats W. Johansson; Elizabeth A. Kelly; Christopher L. Nguyen; Nizar N. Jarjour; Bruce S. Bochner Background: Siglec-8 is present at a high level on human blood eosinophils and low level on blood basophils. Engagement of Siglec-8 on blood eosinophils causes its internalization and results in death...

.... the rs3806933 CC genotype with asthma in boys (p = 0.032, nonsignificant after multiple testing) and the rs2289276 CC genotype with higher eosinophil numbers in asthmatic girls (p = 0.003). The presence of allergic rhinitis in asthmatic children strengthened the association of the rs11466749 GG genotype...

... that have migrated in response to interleukin-8 (IL-8) may lead eosinophils to accumulate in the airways of patients with asthma and possibly aggravate the disease. In this study, we investigated whether formoterol modified the trans-basement membrane migration (TBM) of eosinophils stimulated...

...-controlled study. We measured hyaluronan and versican levels by enzyme-linked immunosorbent assay in sputum collected before and after the 16-week treatment phase. Patients underwent a predefined prednisone tapering schedule if they remained exacerbation free, and sputum eosinophil percentage, asthma control...

...Young-Sin Song; Eun-Mi Yang; Seung-Hyun Kim; Hyun Jung Jin; Hae-Sim Park Background: Aspirin-exacerbated respiratory disease (AERD) is a clinical syndrome associated with chronic inflammation in the airways coincident with chronic rhinitis, sinusitis, recurrent polyposis and asthma. Eosinophils...

...Osamu Kaminuma; Hisako Fujimura; Keiko Fushimi; Koji Ogawa; Aya Nakata; Hideo Kikkawa; Hirokazu Okudaira; Akio Mori Background: The crucial role of T helper (Th) 2 cells in allergic eosinophilic inflammation has been established. Methods: To determine the dynamics of Th2 cells in airway...

.... Akdis M, Trautmann A, Blaser K, Akdis CA: Life span of skin homing T cells in atopic dermatitis: Survival in skin, activation induced apoptosis in peripheral blood. J Allergy Clin Immunol 2000;105:167 (abstr.). 12. Simon H-U, Blaser K: Inhibition of programmed eosinophil death: A key pathogenic...

...Akio Mori; Hirokazu Okudaira; Noriaki Kobayashi; Kazuo Akiyama Background: Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. Methods: The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711...

... free calcium concentration ([Ca 2+ ]i) in human eosinophils. In this study, we have examined the effect of seratrodast on eosinophil cationic protein (ECP) release and changes of [Ca 2+ ]i in human eosinophils induced by PGD 2 . Methods: Eosinophils from healthy donors were incubated with or without IL...