... to play a key role in immune responses, studies investigating the role of DCs in COPD are quite limited. Methods: Porcine pancreas elastase was intratracheally administered to C57BL/6J mice on day 0. On days 2, 7 and 14, emphysema formation was evaluated by pressure-volume relationships and microscopic...

... to be understood. Since eosinophils express protease-activated receptor 2, neutrophil-derived serine proteases may activate eosinophils. Objective: We investigated the effect of neutrophil serine proteases on eosinophil effector functions. Methods: Peripheral blood eosinophils were stimulated with elastase...

... ]. Intratracheal stimulation in vivo with the proinflammatory cytokine rIL-1β alone increases neutrophil recruitment but not elastase activity in rat airways in vivo, as demonstrated in BAL fluid [ 48 ]. However, intratracheal stimulation with hIL-17, in an equally effective dose in terms of neutrophil recruitment...

... that cleavage occurred close to the Cε2/Cε3 domain interface of the IgE heavy chain. PMSF and elastatinal inhibited cleavage, suggesting that the protease involved is an elastase-like serine protease, particularly since porcine pancreatic elastase also cleaved IgE to give similar-sized products. Further...