... inflammation. Conjugated linoleic acid Asthma Eicosanoids Farm milk Phospholipids Eosinophils In many regions of the world, cow's milk consumption has been a common part of the human diet for more than 7,000 years since ancient farmers developed dairy culture [ 1 ]. In industrialized countries...

... in arachidonic acid metabolism. Although considerable amounts of data concerning impaired eicosanoid production are available, the precise mechanism and pathogenesis of the disease are still unknown. The aim of the present study was to assess the expression of enzymes belonging to the arachidonic acid cascade...

... investigated the effects of increased glucose concentrations on FcεRI-mediated mast cell activation by monitoring the degranulation response and eicosanoid production in bone marrow-derived mouse mast cells (BMMCs). Previous studies suggested that glucose deficiency results in a rapid reduction...

... lavage fluid, nasal lavage fluid and epithelial cell cultures. To examine eicosanoid metabolism after exposure to ozone, human nasal mucosa derived from 21 patients undergoing surgical therapy for chronic nasal obstruction was cultured with a specially designed in vitro organ culture device and exposed...

...S.R. Chavali; W.W. Zhong; T. Utsunomiya; R.A. Forse Sesamin, present in sesame seed oil (SSO), can inhibit Δ-5-desaturase activity and cause accumulation of dihomo-γ-linolenic acid (DGLA), which displaces arachidonic acid, and subsequently decrease production of dienoic eicosanoids. The effects...

...Massimo Triggiani; Alfonso Oriente; Gennaro de Crescenzo; Guido Rossi; Gianni Marone The distribution of arachidonic acid (AA) within intracellular lipid pools of inflammatory cells is thought to be an important factor regulating the production of eicosanoids. We have recently identified a pool...

... Microbiology Rigshospitalet, Copenhagen, Denmark Effect of Pseudomonas aeruginosa Alginate on Escherichia coli- and Staphylococcus aureus-Induced Inflammatory Mediator Release from Human Cells Key Words Pseudomonas aeruginosa Cystic fibrosis Aginate Inflammatory mediators Histamine Eicosanoids Hemolysins...

... membrane receptors. Therefore, sPLA 2 s may have an important role in inflammatory and allergic reactions by activating multiple mechanisms within inflammatory and immune cells, leading to the production of eicosanoids, cytokines and chemokines. Table 1 Classification of PLA 2 s The first...

...–derived eicosanoid, LTC 4 . Conclusion: Lipid bodies in eosinophils function as intracellular domains that are both depots of esterified arachidonate and sites at which regulated enymatic events relevant to arachidonate metabolism can occur. In conjunction with our findings that key eicosanoid–forming...