... of GC and THC treatment in a mouse model of allergic asthma. Methods: BALB/c mice were randomly divided into 5 groups: the control group, ovalbumin (OVA)-induced group, and OVA-induced mice treated with dietary THC only, intraperitoneal injection of dexamethasone (DEX) only, or THC combined with DEX...

... of glucocorticoid treatment. Our study helped in understanding the contribution of miRNAs to the pathogenesis of asthma. Asthma Mimic or antagomir Inflammation Animal models Dexamethasone Asthma, also known as bronchial asthma, is a common airway inflammatory disease. The incidence of asthma...

...Barry K. Wershil; Glenn T. Furuta; Jackie A. Lavigne; Anjona Roy Choudhury; Zhen S. Wang; Stephen J. Galli Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere...

... corticosteroids throughout the course of CREAE in the Biozzi ABH mouse and found that major fluctuations in systemic levels coincide with the relapsing-remitting phases of the disease. Furthermore, increasing circulating adrenocorticoids through administration of the steroidal compound dexamethasone markedly...

...V. Puigneró; J. Salgado; J. Queralt The suppressive effects of cyclosporine A (CsA) and dexamethasone (Dxt) on antigen-specific IgE responses to ovalbumin (OA) were studied in BALB/c mice. The effects upon other isotypes were also analyzed. The antiovalbumin IgE response did not change when low...

... of the animals with the immunosuppressive drugs rapamycin and dexamethasone but not cyclosporin, our results also suggested that distinct immunological pathways may be involved in the modulation of the chronic phase of inflammation induced by Sephadex beads in rat paws. 22 05 1995 10 10 1995 4 9...

... expression of many cytokines which induce inflammatory reactions. We examined the effect of dexamethasone on the gene expression and production of IL-10 by human peripheral blood mononuclear cells (PBMCs) and monocytes. PBMCs and monocytes from 5 healthy volunteers were incubated with or without...

...G. Zwadlo-Klarwasser; R. Neubert; R. Stahlmann; W. Schmutzler Subcutaneous injection of the glucocorticoid dexamethasone in the primate Callithrix jacchus increased the proportion of the macrophage subtype RM 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. The elevated...

... degranulation of mast cells and infiltration of basophils and eosinophils in the superficial dermis as the characteristics of the skin reaction in the immediate and late phase, respectively. Pretreatment of TDI-sensitized animals with dexamethasone, a steroidal agent, mepyramine, an antagonist of the histamine...

... than N-Eos. When eosinophils were cultured with IL-5 in vitro, the surface galectin-9 expression of E-Eos was significantly downregulated, although that of N-Eos was not affected. Treatment of eosinophils with dexamethasone or anti-Fas antibody significantly upregulated the surface galectin-9...

... MoDCs were treated with dexamethasone (Dex) during the stimulation, Dex significantly suppressed the augmentation of CD86 expression and TNF-α production induced by all of these stimulations. In contrast, when MoDCs were treated with CyA, it inhibited only the effects induced by the superantigens, SEA...

... investigated the effects of dexamethasone and cyclosporin A on the airway eosinophilic inflammation in mice transferred with T cell clones. An ovalbumin-reactive T cell clone, KW29, produced IL-5 as well as IL-2 and IL-4 upon stimulation with relevant antigen. Dexamethasone and cyclosporin A dose-dependently...