...Ji Woo Yeon; Byoungjae Kim; Junhyoung Byun; Semyoung Jung; Jaehyung Park; Munsoo Han; Seung-Kuk Baek; Tae Hoon Kim Introduction: Allergic diseases are mediated by T helper cell type 2 (Th2) cells, which are differentiated by dendritic cells (DCs). Recently, it was reported that cAMP concentration...

...Hélène Karlen; Shida Yousefi; Hans-Uwe Simon; Dagmar Simon Background: An increased expression of interleukin (IL)-15, a cytokine with a key role in stimulating innate and adaptive immune cells, such as dendritic cells (DC), natural killer cells, and T cells, has been observed in infectious...

...Gerco den Hartog; Christine van Altena; Huub F.J. Savelkoul; R.J. Joost van Neerven Non-inflammatory dendritic cell (DC) subsets play an essential role in preventing massive inflammation in mucosal tissues. We investigated whether mucosa-related factors, namely retinoic acid (RA) and transforming...

... exacerbation of asthma. Considering the plethora of potential cellular targets for MK, specific mechanisms for its therapeutic action are still not fully understood. In vitro, we determined whether human dendritic cell function could be affected by leukotriene C 4 (LTC 4 ) treatment and whether MK had...

...) is an intracellular aspartic endoprotease which is expressed in immune cells like dendritic cells (DCs). It was found to play an essential role in the processing and presentation of ovalbumin (OVA). The aim of the present study was to investigate the inhibition of Ctse in two different experimental models of allergic...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Contact hypersensitivity Hapten Dendritic cell Tc1 cell Contact hypersensitivity (CHS) is a T cell-mediated allergic reaction. It can...

... surface of mast cells, T helper (Th) 2 cells, basophils, eosinophils, dendritic cells, and invariant natural killer (NK) T cells [ 4,5,6,7,8,9,10,11,12,13,14,15 ]. IL-1R accessory protein (IL-1RAcP) is required for IL-33-mediated signal transduction [ 16 ]. As a cytokine, IL-33 signals by interacting...

...Koichi Kuribayashi; Masayuki Tsukiyama; Torn Takenaka The expression of cytokine mRNAs in mice during immune deviation was examined. A subcutaneous injection of antigen-pulsed dendritic cells (DCs) induced strong delayed-type hypersensitivity (DTH) but not humoral immunity, but an intravenous...

...: Pulmonary inflammation was induced in mice by repeated intranasal administration of dusts. Monocyte-derived human dendritic cells (moDCs) were exposed to dusts followed by coculture with purified naïve T cells. Cytokine/chemokine mRNA and protein levels were analyzed by real-time polymerase chain reaction...

...Danita H. Schuurhuis; Nathalie Fu; Ferry Ossendorp; Cornelis J.M. Melief Dendritic cells (DC) are professional antigen-presenting cells which are strategically positioned at the boundaries between the inner and the outside world, in this way bridging innate and adaptive immunity. DC can initiate T...

.... Contact hypersensitivity Hapten CD8+ T lymphocyte Dendritic cell Skin homing Immunotherapy Several of our CTL clones specific for peptides with TNP in the central position 4 were able to recognize the hapten on a variety of unrelated carrier peptides [ 22, 24 ]. This promiscuous, relatively...

... on the functional differentiation of naive CD4 + T cells were investigated by culturing naive CD4 + T cells derived from DO11.10 mice and OVA-pulsed dendritic cells (CDCs) with ONO-4007. Results: ONO-4007 inhibited antigen-specific IgE and IgG 1 , but not IgG 2a responses. ONO-4007 decreased the recruitment...

... system. Examples discussed in this review include molecular descriptions of the differentiation program of T helper (Th) cells into Th1 and Th2 pathways and the genetic program underlying maturation of dendritic cells. It is anticipated that this new information can be used to understand gene function...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immune response Tonsil M-cell Dendritic cell CD40/CD40L Every breath we take and every swallow contains antigenic material. Although...

... lines (TCL) and clones (TCC). Dendritic cells and PBMC were compared in terms of their relative efficacies as antigen–presenting cells. Results: Both allergen and allergoid induced proliferation and Th2 and Th1 cytokine synthesis by PBMC of allergic subjects, whereas PBMC of nonallergic subjects did...