... and demethoxyviridin (DMV), are widely used to block signaling via this molecule and link certain receptors to the PI3-kinase pathway Methods: We have studied the extent of involvement of PI3-kinase in signaling events by Fc ε RI in mast cells using a mouse mast cell line as a model system. This was done using β...

... addressed this issue using transient transfections of a TNFα promoter-driven reporter gene and corresponding 5′ successive deletions, the two phosphoinositol-3 kinase inhibitors demethoxyviridin and wortmannin, ELISAs and Western and Southwestern blots. Results: Nuclear factor of activated T cells (NF...