... Graves’ disease and induced thyrotoxicosis, we detected a significant increase in the levels of interferon-γ, active interfollicular infiltration and degranulation of mast cells, and the intrathyroid overexpression of CD86. Complex analysis of the rat’s thyroid morphofunctional state and systemic...

... concentrations of anti-FcεRI α-chain mAb (CRA-1 mAb), and their cell functions were assessed. Results: Basophils preincubated with CRA-1 mAb at as low as 1 ng/ml for 1 h showed significantly enhanced degranulation in response to various secretagogues such as MCP-1, FMLP, leukotriene B 4 and Ca ionophore A23187...

... immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE). In addition to IKK2, a recent study has shown that ELKS, a regulatory subunit of the IKK complex, also induces...

... activation, particularly the degranulation response and LTC 4 secretion after prolonged culture of mast cells with high-glucose medium. Moreover, it is suggested that increased phosphorylation of cPLA 2 at the Ser505 residue contributes to the enhancement of LTC 4 secretion. 4 6 2010 © 2010 S...

... Basophils FcεRI receptor Histamine Degranulation Blastocyst implantation Seminal vesicle protein number 4 (SV-IV, according to its mobility in SDS-PAGE; precursor UniProtKB/Swiss-Prot ID, SVS4_RAT; accession No. P02783) is a purified and extensively characterized (M r = 9,758; pI = 8.9...

..., and certain eye diseases. The effector functions of eosinophils appear to be derived primarily from release of lipid mediators and proteins, including cytokines and granule proteins. Eosinophil degranulation results in the release of several cytotoxic cationic granule proteins. Furthermore, release...

... School, Boston, Mass., and La Jolla Institute for Allergy and Immunology. La Jolla. Calif., USA Original Paper Int Arch Allergy Immunol 19 % :111:118 125 Spontaneous Degranulation of Cultured Bone-Marrow-Derived Immature Mast Cells from X-Linked Immunodeficient (Xid) Mice Key Words Mast cell Xid mice...

... factor and nerve growth factor affected only LTC 4 production. The optimal preincubation period for priming of LTC 4 production by IL-3 or IL-5 was 90 min, while that for eosinophil cationic protein release was 10 min. These results indicate that degranulation and the generation of lipid mediators...

... and its ligands might induce eosinophil activation and might be involved in degranulation of eosinophil granule proteins, e.g. eosinophil cationic protein and eosinophil-derived neurotoxin. 4 9 2009 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...-hexosaminidase release assays, a leukotriene ELISA, transient transfections with reporter gene constructs of TNFα and MARC, and in addition a TNFα ELISA. Results: Consistent with previously published data in the rat basophilic cell line RBL-2H3, we find that wortmannin as well as DMV prevent the degranulation...

...Takao Fujisawa; Akihiko Terada; Jun Atsuta; Kosei Iguchi; Hitoshi Kamiya; Minoru Sakurai The ability of IL-5 to induce eosinophil degranulation was investigated. Peripheral blood eosinophils from patients with mildly allergic individuals were isolated with CD 16- selection method. Eosinophils were...

...Masahiko Kato; Hirohito Kita; Akihiro Morikawa Degranulation of eosinophils and subsequent release of toxic granule proteins play a key role in allergic diseases such as bronchial asthma. However, little is known about the intracellular signaling mechanism of eosinophil degranulation...

...Shigeru Takafuji; Kenji Tadokoro; Koji lto; Clemens A. Dahinden It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when...

.... 2 9 2009 Beige rats Chédiak-Higashi syndrome Mast cells Degranulation Granules, giant Original Paper Int Arch Allergy Immunol 1993;100:99-106 Tomoko Jippo-Kanemotoa Tsutomu Kasugaia Atsushi YamatodanP Hiroko Ushioc Takatoshi Mochizukib Kazuo Tohyad Michio Kimurad Masahiko Nishimurae...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FcεRI Pyruvate kinase Yeast two–hybrid system Degranulation FcεRI...

... mouse bone marrow-derived mast cells were transferred. Results: Pam3CSK4 and Bifidobacterium pseudocatenulatum JCM 7041 suppressed degranulation of IgE-sensitized mast cells upon antigen stimulation in vitro. Pam3CSK4 also suppressed leukotriene C 4 production triggered by engagement of the high...

... of PI3Ks on the FcεRI-mediated migration toward the antigen (Ag). In the present study, we explored the role of PI3Kγ on mast cell migration. The treatment of bone marrow-derived mast cells (BMMCs) with a PI3Kγ inhibitor, AS605240, significantly repressed FcεRI-induced degranulation and migration...

... species Degranulation Asthma is a complex chronic airway disorder characterized by allergen-induced airway inflammation, elevated serum IgE and airway hyperresponsiveness (AHR). Eosinophils play an important role in the mechanism of allergic airway inflammation [ 1 ]. The activation...

... by preincubation with human IgG3. Conclusions: Canine FcγRI possesses a significant binding activity with human IgG1 or IgG4, while IgG2 or IgG3 did not significantly react with canine FcγRI on CM-MC cells. Mast cell Fc receptor IgG receptor Degranulation Fig. 1 The binding of human IgG to canine...

.... Methods: Purified eosinophils from the peripheral blood were incubated with various concentrations (0–200 µg/ml) of German cockroach extract antigen. Effector functions of eosinophils were checked by degranulation and superoxide anion production. In addition, we examined surface expression of CD11b...