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Keywords: Degranulation
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Journal Articles
Journal Articles
Int Arch Allergy Immunol (2013) 161 (Suppl. 2): 23–31.
Published Online: 29 May 2013
... concentrations of anti-FcεRI α-chain mAb (CRA-1 mAb), and their cell functions were assessed. Results: Basophils preincubated with CRA-1 mAb at as low as 1 ng/ml for 1 h showed significantly enhanced degranulation in response to various secretagogues such as MCP-1, FMLP, leukotriene B 4 and Ca ionophore A23187...
Journal Articles
Int Arch Allergy Immunol (2012) 158 (Suppl. 1): 92–95.
Published Online: 15 May 2012
... immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE). In addition to IKK2, a recent study has shown that ELKS, a regulatory subunit of the IKK complex, also induces...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2010) 151 (4): 318–330.
Published Online: 22 October 2009
... Basophils FcεRI receptor Histamine Degranulation Blastocyst implantation Seminal vesicle protein number 4 (SV-IV, according to its mobility in SDS-PAGE; precursor UniProtKB/Swiss-Prot ID, SVS4_RAT; accession No. P02783) is a purified and extensively characterized (M r = 9,758; pI = 8.9...
Journal Articles
Int Arch Allergy Immunol (1996) 109 (3): 207–215.
Published Online: 04 September 2009
..., and certain eye diseases. The effector functions of eosinophils appear to be derived primarily from release of lipid mediators and proteins, including cytokines and granule proteins. Eosinophil degranulation results in the release of several cytotoxic cationic granule proteins. Furthermore, release...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (1995) 108 (Suppl. 1): 36–38.
Published Online: 04 September 2009
... factor and nerve growth factor affected only LTC 4 production. The optimal preincubation period for priming of LTC 4 production by IL-3 or IL-5 was 90 min, while that for eosinophil cationic protein release was 10 min. These results indicate that degranulation and the generation of lipid mediators...
Journal Articles
Journal Articles
Journal Articles
Int Arch Allergy Immunol (1997) 114 (Suppl. 1): 81–83.
Published Online: 04 September 2009
...Takao Fujisawa; Akihiko Terada; Jun Atsuta; Kosei Iguchi; Hitoshi Kamiya; Minoru Sakurai The ability of IL-5 to induce eosinophil degranulation was investigated. Peripheral blood eosinophils from patients with mildly allergic individuals were isolated with CD 16- selection method. Eosinophils were...
Journal Articles
Int Arch Allergy Immunol (1997) 114 (Suppl. 1): 14–17.
Published Online: 04 September 2009
...Masahiko Kato; Hirohito Kita; Akihiro Morikawa Degranulation of eosinophils and subsequent release of toxic granule proteins play a key role in allergic diseases such as bronchial asthma. However, little is known about the intracellular signaling mechanism of eosinophil degranulation...
Journal Articles
Int Arch Allergy Immunol (1994) 104 (Suppl. 1): 27–29.
Published Online: 03 September 2009
...Shigeru Takafuji; Kenji Tadokoro; Koji lto; Clemens A. Dahinden It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (1999) 119 (2): 95–100.
Published Online: 14 July 2009
..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FcεRI Pyruvate kinase Yeast two–hybrid system Degranulation FcεRI...
Journal Articles
Int Arch Allergy Immunol (2009) 150 (4): 359–369.
Published Online: 01 July 2009
... mouse bone marrow-derived mast cells were transferred. Results: Pam3CSK4 and Bifidobacterium pseudocatenulatum JCM 7041 suppressed degranulation of IgE-sensitized mast cells upon antigen stimulation in vitro. Pam3CSK4 also suppressed leukotriene C 4 production triggered by engagement of the high...
Journal Articles
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2004) 135 (2): 154–160.
Published Online: 08 October 2004
... by preincubation with human IgG3. Conclusions: Canine FcγRI possesses a significant binding activity with human IgG1 or IgG4, while IgG2 or IgG3 did not significantly react with canine FcγRI on CM-MC cells. Mast cell Fc receptor IgG receptor Degranulation Fig. 1 The binding of human IgG to canine...
Journal Articles
Int Arch Allergy Immunol (2004) 134 (2): 141–149.
Published Online: 14 June 2004
.... Methods: Purified eosinophils from the peripheral blood were incubated with various concentrations (0–200 µg/ml) of German cockroach extract antigen. Effector functions of eosinophils were checked by degranulation and superoxide anion production. In addition, we examined surface expression of CD11b...