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1-20 of 37
Keywords: Degranulation
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Journal Articles
Subject Area:
Immunology and Allergy
Shan-Shan Li, Xue-Li Pu, Jing-Ru Zhou, Chun-Sheng Wang, Jia-Ling Wang, Xilizati Kulaixi, Jian-Rong Ye
Int Arch Allergy Immunol (2025)
Published Online: 12 March 2025
...Shan-Shan Li; Xue-Li Pu; Jing-Ru Zhou; Chun-Sheng Wang; Jia-Ling Wang; Xilizati Kulaixi; Jian-Rong Ye Introduction: This study aimed to investigate the role of Raf kinase inhibitor protein (RKIP) in degranulation induced by echinococcal cyst fluid (EgCF) in bone marrow-derived mast cells (BMMCs...
Journal Articles
Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases
Available to PurchaseSubject Area:
Immunology and Allergy
Victoria Vladimirovna Zdor, Boris Izraelivich Geltser, Marina Gennadiyevna Eliseikina, Elena Vladimirovna Markelova, Yaakov Nikolayevich Tikhonov, Natalia Gennadiyevna Plekhova, Alexander V. Karaulov
Int Arch Allergy Immunol (2020) 181 (9): 715–726.
Published Online: 08 July 2020
... Graves’ disease and induced thyrotoxicosis, we detected a significant increase in the levels of interferon-γ, active interfollicular infiltration and degranulation of mast cells, and the intrathyroid overexpression of CD86. Complex analysis of the rat’s thyroid morphofunctional state and systemic...
Journal Articles
Pretreatment with Low Levels of FcεRI-Crosslinking Stimulation Enhances Basophil Mediator Release
Available to PurchaseSubject Area:
Immunology and Allergy
Rikiya Koketsu, Masao Yamaguchi, Maho Suzukawa, Yusuke Tanaka, Hiroyuki Tashimo, Hidenori Arai, Hiroyuki Nagase, Kenji Matsumoto, Hirohisa Saito, Chisei Ra, Kazuhiko Yamamoto, Ken Ohta
Int Arch Allergy Immunol (2013) 161 (Suppl. 2): 23–31.
Published Online: 29 May 2013
... concentrations of anti-FcεRI α-chain mAb (CRA-1 mAb), and their cell functions were assessed. Results: Basophils preincubated with CRA-1 mAb at as low as 1 ng/ml for 1 h showed significantly enhanced degranulation in response to various secretagogues such as MCP-1, FMLP, leukotriene B 4 and Ca ionophore A23187...
Journal Articles
Critical Roles of IĸB Kinase Subunits in Mast Cell Degranulation
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (2012) 158 (Suppl. 1): 92–95.
Published Online: 15 May 2012
... immunoglobulin E-mediated degranulation in mast cells by phosphorylating SNAP-23, the target-membrane soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor (SNARE). In addition to IKK2, a recent study has shown that ELKS, a regulatory subunit of the IKK complex, also induces...
Journal Articles
Prolonged Culture of Mast Cells with High-Glucose Medium Enhances the FcεRI-Mediated Degranulation Response and Leukotriene C 4 Production
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (2010) 152 (Suppl. 1): 22–31.
Published Online: 04 June 2010
... activation, particularly the degranulation response and LTC 4 secretion after prolonged culture of mast cells with high-glucose medium. Moreover, it is suggested that increased phosphorylation of cPLA 2 at the Ser505 residue contributes to the enhancement of LTC 4 secretion. 4 6 2010 © 2010 S...
Journal Articles
Antiapoptotic Seminal Vesicle Protein IV Induces Histamine Release from Human FcεRI+ Cells
Available to PurchaseSubject Area:
Immunology and Allergy
Nella Prevete, Francesca Wanda Rossi, Massimo Triggiani, Gianni Marone, Amato de Paulis, Vittoria Metafora, Salvatore De Maria, Maria Cartenì, Raffaele Ragone, Gianpietro Ravagnan, Salvatore Metafora
Int Arch Allergy Immunol (2010) 151 (4): 318–330.
Published Online: 22 October 2009
..., instructions or products referred to in the content or advertisements. Protein SV-IV Mast cells Basophils FcεRI receptor Histamine Degranulation Blastocyst implantation Seminal vesicle protein number 4 (SV-IV, according to its mobility in SDS-PAGE; precursor UniProtKB/Swiss-Prot ID...
Journal Articles
Eosinophils in Allergy: Role in Disease, Degranulation, and Cytokines
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1996) 109 (3): 207–215.
Published Online: 04 September 2009
..., and certain eye diseases. The effector functions of eosinophils appear to be derived primarily from release of lipid mediators and proteins, including cytokines and granule proteins. Eosinophil degranulation results in the release of several cytotoxic cationic granule proteins. Furthermore, release...
Journal Articles
Spontaneous Degranulation of Cultured Bone-Marrow-Derived Immature Mast Cells from X-Linked Immunodeficient (Xid) Mice
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1996) 111 (2): 118–125.
Published Online: 04 September 2009
... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mast cell Xid mice Secretion Degranulation...
Journal Articles
Effects of Physiologic Soluble Agonists on Leukotriene C 4 Production and Degranulation by Human Eosinophils
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1995) 108 (Suppl. 1): 36–38.
Published Online: 04 September 2009
... factor and nerve growth factor affected only LTC 4 production. The optimal preincubation period for priming of LTC 4 production by IL-3 or IL-5 was 90 min, while that for eosinophil cationic protein release was 10 min. These results indicate that degranulation and the generation of lipid mediators...
Journal Articles
Possible Release of Eosinophil Granule Proteins in Response to Signaling from Intercellular Adhesion Molecule-1 and its Ligands
Available to PurchaseSubject Area:
Immunology and Allergy
Junichi Chihara, Takahiro Yamamoto, Dai Kurachi, Tomokazu Kakazu, Ikkou Higashimoto, Shigenori Nakajima
Int Arch Allergy Immunol (1995) 108 (Suppl. 1): 52–54.
Published Online: 04 September 2009
... and its ligands might induce eosinophil activation and might be involved in degranulation of eosinophil granule proteins, e.g. eosinophil cationic protein and eosinophil-derived neurotoxin. 4 9 2009 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights...
Journal Articles
IL-5 as a Strong Secretagogue for Human Eosinophils
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1997) 114 (Suppl. 1): 81–83.
Published Online: 04 September 2009
...Takao Fujisawa; Akihiko Terada; Jun Atsuta; Kosei Iguchi; Hitoshi Kamiya; Minoru Sakurai The ability of IL-5 to induce eosinophil degranulation was investigated. Peripheral blood eosinophils from patients with mildly allergic individuals were isolated with CD 16- selection method. Eosinophils were...
Journal Articles
Role of Tyrosine Kinases in Human Eosinophil Degranulation
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1997) 114 (Suppl. 1): 14–17.
Published Online: 04 September 2009
...Masahiko Kato; Hirohito Kita; Akihiro Morikawa Degranulation of eosinophils and subsequent release of toxic granule proteins play a key role in allergic diseases such as bronchial asthma. However, little is known about the intracellular signaling mechanism of eosinophil degranulation...
Journal Articles
Effects of Phosphatidylinositol-3-Kinase Inhibitors on Degranulation and Gene Induction in Allergically Triggered Mouse Mast Cells
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1997) 112 (4): 392–399.
Published Online: 04 September 2009
...-hexosaminidase release assays, a leukotriene ELISA, transient transfections with reporter gene constructs of TNFα and MARC, and in addition a TNFα ELISA. Results: Consistent with previously published data in the rat basophilic cell line RBL-2H3, we find that wortmannin as well as DMV prevent the degranulation...
Journal Articles
Degranulation from Human Eosinophils Stimulated with C3a and C5a
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1994) 104 (Suppl. 1): 27–29.
Published Online: 03 September 2009
...Shigeru Takafuji; Kenji Tadokoro; Koji lto; Clemens A. Dahinden It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when...
Journal Articles
Supernormal Histamine Release and Normal Cytotoxic Activity of Beige (Chédiak-Higashi Syndrome) Rat Mast Cells with Giant Granules
Available to PurchaseSubject Area:
Immunology and Allergy
Tomoko Jippo-Kanemoto, Tsutomu Kasugai, Atsushi Yamatodani, Hiroko Ushio, Takatoshi Mochizuki, Kazuo Tohya, Michio Kimura, Masahiko Nishimura, Yukihiko Kitamura
Int Arch Allergy Immunol (1993) 100 (2): 99–106.
Published Online: 02 September 2009
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Beige rats Chédiak-Higashi syndrome Mast cells Degranulation Granules, giant Original Paper Int Arch Allergy Immunol 1993;100:99-106 Tomoko Jippo-Kanemotoa Tsutomu Kasugaia...
Journal Articles
Activation of Fc Epsilon RI Inhibits the Pyruvate Kinase through Direct Interaction with the Gamma–Chain
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (1999) 119 (2): 95–100.
Published Online: 14 July 2009
... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FcεRI Pyruvate kinase Yeast two–hybrid system Degranulation FcεRI, a tretamer...
Journal Articles
A TLR2 Ligand Suppresses Allergic Inflammatory Reactions by Acting Directly on Mast Cells
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (2009) 150 (4): 359–369.
Published Online: 01 July 2009
... mouse bone marrow-derived mast cells were transferred. Results: Pam3CSK4 and Bifidobacterium pseudocatenulatum JCM 7041 suppressed degranulation of IgE-sensitized mast cells upon antigen stimulation in vitro. Pam3CSK4 also suppressed leukotriene C 4 production triggered by engagement of the high...
Journal Articles
PI3Kγ Differentially Regulates FcεRI-Mediated Degranulation and Migration of Mast Cells by and toward Antigen
Available to PurchaseSubject Area:
Immunology and Allergy
Int Arch Allergy Immunol (2009) 149 (Suppl. 1): 66–72.
Published Online: 03 June 2009
... of PI3Ks on the FcεRI-mediated migration toward the antigen (Ag). In the present study, we explored the role of PI3Kγ on mast cell migration. The treatment of bone marrow-derived mast cells (BMMCs) with a PI3Kγ inhibitor, AS605240, significantly repressed FcεRI-induced degranulation and migration...
Journal Articles
Hepatocyte Growth Factor Suppresses Production of Reactive Oxygen Species and Release of Eosinophil-Derived Neurotoxin from Human Eosinophils
Available to PurchaseSubject Area:
Immunology and Allergy
Wataru Ito, Masahide Takeda, Miyoshi Fujita, Yumiko Kamada, Hikari Kato, Takahito Chiba, Kazutoshi Yamaguchi, Shigeharu Ueki, Hiroyuki Kayaba, Arihiko Kanehiro, Junichi Chihara
Int Arch Allergy Immunol (2008) 147 (4): 331–337.
Published Online: 12 July 2008
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatocyte growth factor Asthma Eosinophil Reactive oxygen species Degranulation Asthma is a complex chronic airway disorder characterized by allergen-induced airway...
Journal Articles
Canine Mast Cell Activation via Human IgG1 and IgG4
Available to PurchaseSubject Area:
Immunology and Allergy
Yoshitaka Sato, Reiko Teshima, Ryosuke Nakamura, Kayoko Takagi, Nobuo Sasaki, Jun-ichi Sawada, Seiichi Kitani
Int Arch Allergy Immunol (2004) 135 (2): 154–160.
Published Online: 08 October 2004
... min at 37°C. After the degranulation (histamine release) reactions were terminated by centrifugation at 4°C for 5 min, the supernatants were collected. Perchloric acid was added to them up to the final concentration of 1.2% to precipitate proteins in the fluid. All samples were kept at 4°C overnight...
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