... by hypothermia shock response (HSR). Mucosal mast cell degranulation was measured by the elevation of mMCP-1 in the blood. The mice were monitored for dermatitis. Skin tissues were used in histopathology and for measuring cytokine/chemokine/adhesion molecule levels using a protein microarray system. Results...

...Jun Shoji; Yoko Nakanishi; Akiko Ishimori; Tohru Sakimoto; Noriko Inada; Norimichi Nemoto Background: Massive B cell lymphoid hyperplasia and its associated factors may play a role in exacerbating inflammation in allergic disorders. We here investigated the chemokines and CD4-positive T cell subset...

...Shingo Ochiai; Naoki Shimojo; Yoshinori Morita; Minako Tomiita; Takayasu Arima; Yuzaburo Inoue; Mayuko Nakaya; Naoki Uehara; Yasunori Sato; Chisato Mori; Yoichi Suzuki; Yoichi Kohno Background: A few studies have reported that the quantity of selected cytokines/chemokines in breast milk might...

...) were generated by site-directed mutagenesis and an assay with artificial peptide substrates was used to compare two types of MMP12 activity. The effect of MMP12 inhibition with MMP12-specific small interfering RNA (siRNA) on chemokine secretion from airway epithelial cells was also tested in vitro...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diesel Particulate Pollution Cytokine Airway inflammation Asthma Chemokine...

... have not been examined. Methods: Fifteen asthmatic volunteers each received omalizumab for 12 weeks. Peripheral blood basophils were isolated before, during, 2 weeks after and 6 months after omalizumab. Basophils were assayed for the basal and anti-IgE-stimulated release of cytokines, chemokines...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Allergic rhinitis Eosinophil Adhesion molecule Chemokine Signal transduction p38 MAP kinase Nuclear factor-ĸB The accumulation of eosinophils, releasing...

...-independent histamine-releasing factors (HRF). In this study, we examined the effect of a panel of kinase inhibitors on MCP-1-induced histamine release from human basophils to characterize the signaling pathway used by this chemokine. Genistein (3 μg/ml), an inhibitor of tyrosine kinase, inhibited MCP-1...

... to in the content or advertisements. Bronchial epithelial cell Influenza virus Interleukin Chemokine InicmatKHul Archives of Allergy , Immunology Short Com m unication 3. Inflam m ation Ilit Arch Allergy Immunol 1997;! 13:307-311 Mitsuru Adachi Satoshi Matsukura Hisahiro Tokunaga Fumio Kokubu First...

... supernatants and this chemotaxin was identified as the chemokine RANTES. The isolation of natural RANTES and its activity for eosinophil migration is summarized here. RANTES induced eosinophil migration at nanomolar range, in both chemotactic and chemokinetic manners. Specific desensitization experiments...

..., is derived from CTAP III by cleavage with elastase. All are members of the intercrine/chemokine group of cytokine-like molecules many of which are chemotactic factors and/or activate other cells. Interleukin 8 (NAP-1), another chemokine inhibits histamine release induced by all known forms of HRF...

...Teizo Yoshimura; Motohiro Takeya; Hiroomi Ogata; Shigeo Yamashiro; William S. Modi; Reinhard Gillitzer Background: CXC chemokines, IL–8 and GRO, play a role in the recruitment of neutrophils in the human. The functional orthologues in the rat and mouse are CINC/KC and MIP–2. The lack of IL–8 made...

... thus hypothesized that LAB influence the host immune system through the activation of IECs. To begin testing this hypothesis, chemokine expression in IECs exposed to intestinal bacteria was investigated. Methods: Caco-2 cell monolayers were stimulated with different concentrations of various live...

...Irene H. Heijink; Henk F. Kauffman; Edo Vellenga; Christa A. Veltman-Starkenburg; Dirkje S. Postma; Jan G.R. de Monchy Background: The allergen-induced release of CCL17/thymus and activation-regulated chemokine (TARC) may be crucial in asthmatic airway inflammation by recruitment of Th2 cells...

... or Euroglyphus maynei in the absence or presence of lipopolysaccharide. Culture supernatants were collected 24 h later and assayed for the presence of various chemokines and cytokines. Results: Keratinocytes constitutively secreted interleukin (IL)-1 receptor antagonist/IL-1F3, growth-related oncogene α...

...Martin Depner; Michael S.D. Kormann; Norman Klopp; Thomas Illig; Christian Vogelberg; Stephan K. Weiland; Erika von Mutius; Christophe Combadière; Michael Kabesch Chemokines and their receptors are involved in many aspects of immunity. Chemokine CX3CL1, acting via its receptor CX3CR1, regulates...

.... The migration of eosinophils as well as Th2 cells is controlled by chemokines, suggesting a crucial role of chemokines in the pathogenesis of bronchial asthma. To elucidate the mechanism by which Th2 cells induce eosinophilic inflammation, a Th2-cell-dependent murine model of asthma was employed in this study...

... on the chest and genital area. Normal skin samples of 7 healthy patients undergoing excision of an epidermal cyst, lipoma or pigmented nevus were also obtained under local anesthesia. Mast cell Basal cell carcinoma VEGF IL-8 RANTES Chemokine The anti-human tryptase (Chemicon International Inc...

... of chemokine mRNA in the mast cells. Mast cell Superoxide dismutase Hydrogen peroxide Inflammation Chemokine 30 11 2001 © 2001 S. Karger AG, Basel 2001 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

... mediator release from FcΕRI + cells. gp120 also induces IL-4 and IL-13 synthesis in human basophils. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human FcΕRI + cells. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells...