...Motohiko Suzuki; Makoto Yokota; Tamami Matsumoto; Shinya Ozaki Background: We previously reported that siRNA-induced CD40-silenced dendritic cells (DCs) inhibit allergic responses and symptoms. However, more potent therapies are needed. To our knowledge, synergic effects of gene silencing in DCs...

... immunoglobulin (Ig) isotypes. Helper activity was mediated by staphylococcal super-antigens adsorbed to the T cells prior to fixation and required presence of IL-4 in the cultures. We demonstrated that the T cells neither expressed detectable CD40 ligand at the beginning of the superantigen treatment nor 24 h...

.... Cells were collected sequentially after nasal provocation by nasal lavage, B cells grown in the CD40 system and IgE production assessed by enzyme-linked filter spot assay and radioimmunoassay. IgE-producing B cells were detected after culture of nasal lavage cells in the CD40 system. Elevated levels...

...Yasuhide Uejima; Katsushi Takahashi; Keiji Komoriya; Seizi Kurozumi; Hans D. Ochs We studied the effect of IL-10 on the in vitro synthesis of IgE and IgG by human peripheral blood mononuclear cells (PBMC) follwong stimulation with anti-CD40 monoclonal antibody and IL-4. Anti-CD40- and IL-4...

...Cees van Kooten; Jacques Banchereau CD40, a cell surface receptor which belongs to the TNF-R family, was first identified and functionally characterized on B lymphocytes. In recent years, CD40 has been found expressed on other cells, including monocytes, dendritic cells, endothelial cells...

...E. Castigli; R. Fuleihan; N. Ramesh; E. Tsitsikov; A. Tsytsykova; R.S. Geha CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response...

... lymphokines interleukin (IL)-4 or IL-13 which induce germline ε transcript expression, but alone is insufficient to trigger secretion of IgE. The second signal is provided by a physical interaction between B cells and activated T cells, basophils and mast cells, and it has been shown that the CD40/ CD40L...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. B cells CD40 Interleukin-4 Tumor necrosis factors Effectors and Pathogenesis of Allergic Diseases hit Arch Allergy Immunol 1995:107:368-369 Margitta Worm RaifS. Geha Division o f...