... in the synovial fluid of inflamed joints positively correlated with parameters of disease activity, such as the erythrocyte sedimentation rate (ESR) and levels of C-reactive protein (CRP), in oligoarticular JIA [ 4 ]. CD4+ T cells Biological therapy Cytokines PB samples for the in vitro study were...

... blood (CB) samples from an established cohort of Australian children exposed in the fetal period to either very low or very high levels of maternal folate. Results: Our ChIP assay was validated for a minimum requirement of 1 × 10 5 target cells (e.g. CD4+ T cells). Very high levels of maternal folate...

... of allergic asthma, more severe airway inflammation in female mice is associated with higher levels of T helper type 2 (Th2) cytokines. The aim of this study was to investigate the contributions of CD4 + T cells and dendritic cells (DCs) to the differences in Th2 cytokine production between sexes. Methods...

... two systems have not been studied in sufficient detail. Here, we wished to investigate whether phenotypic features of monocytes and CD4+ T cells in allergic patients are reciprocally related. Therefore, we recruited 50 untreated house dust mite-sensitive allergic rhinitis patients and 29 non-atopic...

... production. Methods: Splenocytes from wild-type mice and CD4+ T cell-, CD8+ T cell-, and iNKT cell-deficient mice were stimulated with anti-CD3/CD28 antibodies for 3 days, and the concentrations of IL-4, IL-5, IL-13, and IFN-γ in the cultures were measured by ELISA. Results: IL-5, but not IL-4 and IL-13...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CD4+ T cells Epidermal cells Flow cytometry Langerhans cells Mice Popliteal lymph node assay Platinum compounds...

... to in the content or advertisements. IL-5 Eosinophil CD4+ T cells Asthma 4 9 2009 International Archives T Allergyand Immunology Int Arch Allergy Immunol 19 9 7 ; 114(suppl 1): 10 13 Osamu Kaminuma& b Akio Mori* Matsunobu Sukoa Ilideo Kikkawab Kazuaki Naitob nirokazu Okudairaa Development...

...-directed biological agents, we show that the early promise displayed by anti-CD4 monoclonal antibodies in open clinical trials has not been sustained in controlled studies. This outcome provides a challenge to the concept that CD4+ T cells are of prime importance in RA, and prompts a search for alternative...

... glomerulonephritis. The development of these HgCl 2 -induced immunological alterations requires CD4 + T cells. The H-2 S haplotype encodes susceptibility and, as far as studied, H-2 d determines resistance. For a better understanding of susceptibility and resistance to HgCl 2 at the level of Th and B cells, we...

.... In addition, we have recently shown that IL-25 mRNA is expressed in the lung after an inhaled antigen challenge in sensitized mice and that neutralization of the produced IL-25 by soluble IL-25 receptor decreases antigen-induced eosinophil and CD4+ T cell recruitment into the airways. Moreover, we have shown...

.../CD8) was 5.2 ± 3.3 at 6 weeks, 6.8 ± 3.7 at 7 weeks, and 1.5 ± 0.8 at 10 weeks of age. The lesional Eo/WBC ratio was directly proportional to the CD4/CD8 ratio (p < 0.05), and was also significantly related to lesional CD4+ T cell count (p < 0.05). IL-5 was also expressed in Eo-rich areas...

... applied to define certain immunological conditions such as allergic diseases. We summarize strategies on gene expression profiling of inflammatory disease and immunologically relevant cells using DNA array technology. Using DNA arrays, gene expression analysis of CD4+ T cells of allergy patients revealed...

.... Results: Antigen-induced eosinophil recruitment into the trachea in BALB/c mice was more than 20 times as abundant as that in C57BL/6 mice, the latter of which was also mediated by CD4+ T cells. In contrast, systemic Th2 responses, which were evaluated by the titers of antigen-specific IgE antibody...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. IL-5 Eosinophils CD4+ T cells...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Atopic disease CD4+ T cells Interleukin 5 Eosinophilic inflammation...