..., instructions or products referred to in the content or advertisements. Asthma CD4+ T cell Eosinophil Mouse Persistent inflammation of the bronchial mucosa is a prominent pathological feature of bronchial asthma [ 1 ]. Eosinophils play a central role in mucosal inflammation, although...

...+ effector cell. Candida albicans CD4+ T cell CD8+ T cell Delayed hypersensitivity Down-regulation I-A antigen Mannan T suppressor cell © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... strated that IL-5 produced by PBMCs is derived exclu­ sively from CD4+ T cells [9], it can be assumed that T-440 suppressed IL-5 production by CD4+ T cells. Additional­ ly, the cyclic AMP analogue, dibutyryl (db) cyclic AMP, 100 pmol/1, also suppressed mite-induced IL-5 produc­ tion by 88% (n = 3...

... CD8 depletion did not. These findings indicated that CD4+ T cells are the principal source of IL-5 in asthmatic PBMCs. The capacity of PBMCs of atopic asthmatics, nonatopic asthmatics and healthy controls to produce IL-2, IL-3, IL-4, interferon-γ and granulocyte/macrophage-colony-stimulating factor...

... of asthmatic patients. A transcription factor, GATA-3, has been implicated in IL-5 gene expression. This study was undertaken to clarify the role of GATA-3 in the upregulation of IL-5 synthesis in asthmatic patients. Method: Peripheral CD4+ T cells were transfected with an IL-5 promoter reporter construct...

...Nobuhiro Matsumoto; Shigeki Katoh; Hiroshi Mukae; Takeshi Matsuo; Kiyoshi Takatsu; Shigeru Matsukura Infiltration of antigen-specific CD4+ T cells and production of interleukin (IL)-5 in inflammatory regions play a central role in antigen-induced pulmonary eosinophilia. Genetically IL-5-deficient...

...+ and CLA– T cells from both, atopic and healthy donors. Conclusions: Single cell analysis revealed a predominant localization of allergen-reactive T cells within the CD7– CLA+ CD4+ T cell subset in AD. Thus, this simple assay not only confirms previously published results, but also extends our knowledge...

...Koji Ogawa; Osamu Kaminuma; Hideo Kikkawa; Rieko Kameda; Katsuo Ikezawa; Matsunobu Suko; Hirokazu Okudaira; Kazuo Akiyama; Akio Mori Background: We have recently demonstrated that allergic eosinophilic inflammation is transferred to unprimed mice by infusing IL-5-producing CD4+ T cells...