..., instructions or products referred to in the content or advertisements. 2014 Toll-like receptors CD14 Hygiene hypothesis Innate immunity Immunotherapy Adjuvants CpG oligodeoxynucleotide Immunostimulatory sequence oligonucleotides Asthma Allergic rhinitis Atopic asthma and allergic...

... has undertaken a systematic analysis of chromosome 5q, and has recently characterized five single nucleotide polymorphisms at position –1619, –1359, –1145, –809 and –159 in the promoter of the gene encoding CD14, the myeloid pattern recognition receptor that is critical for efficient innate immune...

...Giovanna Viale; Donata Vercelli The monocyte glycosylphosphatidylinositol (GPI)-linked protein CD14 serves as the receptor for lipopolysaccharide (LPS), and regulates monocyte-lymphocyte interactions. We investigated whether CD14 expression is regulated by interleukin (IL)-13, a member...

... of IL-10. IL-2 (2 U/ml) did not replete monocyte HLA-DR expression that was inhibited by IL-10. Finally, monocyte expression for surface CD14 was observed to increase with IL-10 treatment and to decrease under conditions of allergen-induced proliferation. Monocyte CD14 expression by IL-10 appeared...

.... Methods: The absolute number of surface CD14, TLR2, TLR4 and CD180 and the CD14-mediated uptake of bodipy-labeled endotoxin and bacteria by whole blood leukocytes was studied by flow cytometry. We measured the serum soluble CD14 concentration by an inhibitory flow cytometric method. Results: We observed...

...Duaine R. Jackola; Saonli Basu; Carol L. Liebeler; Rebecca Willaert; San-San Luah; William Oetting; Richard A. King; Malcolm N. Blumenthal Background: CD14 promoter DNA sequence polymorphisms for the endotoxin receptor gene have been implicated in modulating allergen-specific immunoglobulin (Ig)E...

... pg/ml within 3 h after exposure, and remained decreased until 2 weeks after exposure. This is a cardinal marker for immune suppression which was confirmed by other markers: reduction in HLA-DR expression on alveolar macrophages and CD14 expression on blood monocytes. Conclusion: We report findings...