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Int Arch Allergy Immunol 1–6.
Published Online: 10 November 2023
... were included in this study; urticaria activity score (UAS7) was recorded and the treatment response was judged based on it. Levels of total serum IgE, anti-high-affinity IgE receptor (FcεRI) IgG, and basophils CD63 and FcεRI expressions, and D-dimer of all patients were determined and analyzed...
Int Arch Allergy Immunol (2021) 182 (10): 917–931.
Published Online: 29 April 2021
... pathways discovered in recent years on urticaria, including the cell adhesion/chemotaxis pathway, interleukin (IL)-6/Janus tyrosine kinase/STAT pathway, IL-17/IL-23 pathway, basophil- and mast cell-related pathway, coagulation/fibrinolysis-related pathways, single-nucleotide polymorphism, and some other...
Eric Tyrell Oliver, Kris Chichester, Kelly Devine, Patricia Meghan Sterba, Craig Wegner, Becky Marie Vonakis, Sarbjit Singh Saini
Int Arch Allergy Immunol (2019) 179 (1): 21–30.
Published Online: 15 March 2019
... change. CRTh2 surface expression rose significantly on blood basophils during active treatment. No serious adverse events were observed. Conclusions: This is the first study to examine the efficacy of a CRTh2 antagonist in antihistamine-refractory CSU. AZD1981 treatment was well tolerated, effectively...
Monica Boita, Enrico Heffler, Paola Omedè, Michela Bellocchia, Claudia Bussolino, Paolo Solidoro, Veronica Giorgis, Francesco Guerrera, Giuseppe Riva, Luisa Brussino, Caterina Bucca, Giovanni Rolla
Int Arch Allergy Immunol (2018) 175 (3): 171–176.
Published Online: 03 February 2018
...: To investigate whether the expression of the IL-25, IL-33, and TSLP receptors on the basophil membrane are associated with asthma severity. Twenty-six patients with asthma (11 severe and 15 moderate/mild) and 10 healthy subjects (controls) were enrolled in the study. The results of the basophil activation test...
Gianni Marone, Gilda Varricchi, Stefania Loffredo, Maria Rosaria Galdiero, Felice Rivellese, Amato de Paulis
Int Arch Allergy Immunol (2017) 171 (3-4): 158–165.
Published Online: 14 December 2016
..., significant challenges remain in the fight against HIV. In particular, how uninfected cells capture HIV and transmit virions to target cells remains an unanswered question. Tissue mast cells and peripheral blood basophils can be exposed to virions or HIV products during infection. Several HIV proteins (i.e...
Int Arch Allergy Immunol (2016) 171 (2): 89–101.
Published Online: 02 December 2016
...Peter Korošec; Mira Šilar; Peter Kopač; Renato Eržen; Mihaela Zidarn; Mitja Košnik Background: We sought to determine whether basophil-allergen sensitivity could be transferred to donor basophils by passive IgE sensitisation in allergic rhinitis and anaphylactic Hymenoptera venom hypersensitivity...
Int Arch Allergy Immunol (2016) 169 (1): 1–12.
Published Online: 09 March 2016
...Bernhard Kratzer; Winfried F. Pickl This review highlights the recent key advances in the biology of CD4 + effector T cells, antigen-presenting cells, Th17 and T regulatory cells, as well as immediate effector cells, such as mast cells, basophils and eosinophils, which are critically contributing...
Int Arch Allergy Immunol (2016) 168 (4): 253–262.
Published Online: 20 February 2016
... mast cells. There has been some progress in the description of the mechanism of the activation of mast cells, substances limiting mast cell activation and in the catalogue of proteases that mast cells express. Basophil granulocytes express FcεRI, bind IgE and respond to allergen crosslinking in a very...
Int Arch Allergy Immunol (2014) 164 (4): 271–279.
Published Online: 09 September 2014
...Barbara Dema; Ryo Suzuki; Juan Rivera Immunoglobulin E (IgE) and its high-affinity receptor (FcεRI) are well-known participants in the allergic response. The interaction of allergens with FcεRI-bound IgE antibodies is an essential step in mast cell/basophil activation and the subsequent release...
Yusuke Tanaka, Yuko Nakase, Masao Yamaguchi, Naoya Sugimoto, Kenshin Ohara, Hiroyuki Nagase, Ken Ohta
Int Arch Allergy Immunol (2014) 164 (1): 27–29.
Published Online: 13 May 2014
...Yusuke Tanaka; Yuko Nakase; Masao Yamaguchi; Naoya Sugimoto; Kenshin Ohara; Hiroyuki Nagase; Ken Ohta We describe a case of formaldehyde-induced urticaria with a positive test result for serum IgE antibody against this substance. Formaldehyde's slow protein-binding property may explain why basophil...
Int Arch Allergy Immunol (2013) 161 (1): 87–90.
Published Online: 15 December 2012
...A. Nopp; L.O. Cardell; S.G.O. Johansson Background: A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge. Methods: Twenty-six patients...
Patrizia Pignatti, Barbara Frossi, Gianni Pala, Sara Negri, Hans Oman, Luca Perfetti, Carlo Pucillo, Marcello Imbriani, Gianna Moscato
Int Arch Allergy Immunol (2013) 160 (4): 409–419.
Published Online: 23 November 2012
... for occupational asthma and rhinitis, and ammonium persulfate is the main etiologic agent. Objective: To explore the effects of ammonium persulfate on human albumin, mast cells, and basophils in order to evaluate a possible effect of ammonium persulfate oxidizing activity in the mechanism of ammonium persulfate...
Harald Herrmann, Katharina Blatt, Viviane Ghanim, Michael Kneidinger, Katharina Marth, Rudolf Valenta, Peter Valent
Int Arch Allergy Immunol (2012) 159 (1): 15–22.
Published Online: 27 April 2012
... of histamine in basophils, especially in allergic individuals. In the current study, we asked whether glucocorticosteroids inhibit dasatinib-induced activation of basophils. Methods: Basophils were preincubated with dexamethasone, prednisolone and hydrocortisone for 24 h, and were then exposed to an anti-IgE...
Amato de Paulis, Francesco Annunziato, Luisa Di Gioia, Sergio Romagnani, Maria Carfora, Chiara Beltrame, Gianni Marone, Paola Romagnani
Int Arch Allergy Immunol (2001) 124 (1-3): 146–150.
Published Online: 24 January 2012
... mast cells in the various human tissues examined were tryptase-chymase double-positive. Conclusions: These results indicate that CCR3 is expressed on human mast cells and that these cells are attracted by CCR3-binding chemokines. 24 1 2012 Basophils CCR3 Chemotaxis Histamine Mast cells...
Kaiyu Han, Maho Suzukawa, Masao Yamaguchi, Naoya Sugimoto, Yuko Nakase, Takako Toda, Hiroyuki Nagase, Ken Ohta
Int Arch Allergy Immunol (2011) 155 (Suppl. 1): 64–70.
Published Online: 01 June 2011
...Kaiyu Han; Maho Suzukawa; Masao Yamaguchi; Naoya Sugimoto; Yuko Nakase; Takako Toda; Hiroyuki Nagase; Ken Ohta Background: Basophils are thought to play pivotal roles in the pathogenesis of allergic reactions, but their roles in inflammation associated with systemic abnormalities such as metabolic...
Int Arch Allergy Immunol (2011) 156 (1): 16–26.
Published Online: 29 March 2011
...Francesca Gasparrini; Rosa Molfetta; Angela Santoni; Rossella Paolini The binding of IgE to high-affinity IgE receptors (FcΕRI) expressed on the surface of mast cells and basophils initiates a cascade of signaling events that results in the release of a wide array of proinflammatory mediators...
Int Arch Allergy Immunol (2010) 153 (4): 323–334.
Published Online: 17 June 2010
...Gitte Lund; Henrik Jacobi; Per Stahl Skov; Jens Holm; Kaare Lund Background: Allergen-specific immunotherapy (SIT) leads to reduced symptoms upon allergen exposure through as yet unresolved mechanisms. Desensitization of basophils to specific allergens during the updosing phase of injection...
Nella Prevete, Francesca Wanda Rossi, Massimo Triggiani, Gianni Marone, Amato de Paulis, Vittoria Metafora, Salvatore De Maria, Maria Cartenì, Raffaele Ragone, Gianpietro Ravagnan, Salvatore Metafora
Int Arch Allergy Immunol (2010) 151 (4): 318–330.
Published Online: 22 October 2009
... immunologic, biochemical and molecular biology procedures. Results: SV-IV-induced histamine release from human basophils and lung mast cells without any influence on leukotriene C 4 release and cell migration. The histamine release rate was slower compared with that induced by anti-IgE, the temperature...
Janet M. Oliver, Christy A. Tarleton, Laura Gilmartin, Tereassa Archibeque, Clifford R. Qualls, Lorena Diehl, Bridget S. Wilson, Mark Schuyler
Int Arch Allergy Immunol (2010) 151 (4): 275–284.
Published Online: 22 October 2009
... symptoms. Previously, omalizumab was shown to cause a dramatic and reversible loss of cell surface high-affinity IgE receptors, FcΕRI, from the peripheral blood basophils of asthmatics. The consequences of receptor loss for the FcΕRI-mediated synthesis and release of cytokines implicated in allergic asthma...
Int Arch Allergy Immunol (2010) 151 (2): 89–97.
Published Online: 15 September 2009
...E. Crivellato; L. Travan; D. Ribatti Mast cells and basophils are granulated metachromatic cells which possess complex and partially overlapping roles in acquired and innate immunity, including both effector and regulatory activities. Mast cells and basophils cooperate in exacerbating...