.... Alitretinoin 9- cis- retinoic acid Chronic hand eczema T cells Regulatory T cells Interleukin-17 B cells Plasmablasts Immunoglobulin Previous studies have shown that 9- cis- RA binds with a high affinity to the retinoid X receptor but also to the retinoid A receptor, each consisting of 3...

... of these cytokines in immunologically mediated diseases. B lymphocytes are known to be an important source of cytokines in chronic inflammatory diseases. We therefore investigated the potential of human B lymphocytes to produce IL-17A and IL-17F. Methods: Highly purified B cells were obtained using a multiple-step...

..., B cells and fibroblast-like synoviocytes (FLSs); each is believed to play a significant role in the process of RA. Interactions between T cells and B cells and between T cells and FLSs have been studied in depth. However, it has been showed that B cells also play a critical role in rheumatoid...

...Judith Rosen Farrar; Kenneth Rainey; Alan A. Norris T cells B cells Interleukin-4 IgE Tumor Necrosis factor (TNF) Nedocromil sodium Pyranoquinoline Immunoglobulin Mast cells 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...

...Ramsay Fuleihan; Deborah Ahern; Raif S. Geha CD40 ligand (CD40L) delivers a contact-dependent signal to B cells which, in the presence of interleukin (IL)-4, drives immunoglobulin isotype switching to IgE. CD40L expression in T cells is transient, requires activation of protein kinase C and a rise...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. B cells CD40 Interleukin-4 Tumor necrosis factors Effectors and Pathogenesis of Allergic Diseases hit Arch Allergy Immunol 1995:107:368-369 Margitta Worm RaifS. Geha Division o f...

...Francis Levy; Colette Kristofic; Christoph Heusser; Volker Brinkmann IgE isotype switching of human B cells requires physical interaction of T and B cells via surface molecules, and either IL-4 or IL-13 secreted by T cells. In this study we analyzed the role of IL-4 versus IL-13 in IgE production...

... on the human B cells surviving in the murine environment. In addition, the hIgG levels achived in AT-Scid-hu mice were significantly higher than in scid mice reconstituted with immune cells from patients with Graves’ disease, thus suggesting a difference in the overall reactivity of immune cells in patients...

... in many cases remains incompletely understood, significant strides have been made and it is now clear that there is involvement of several pathways of immune activation, with contributions from both T and B cells. Furthermore, despite the current gaps in our knowledge of the molecular pathogenesis...

... antigens and migrate to the spleen where they transfer antigenic peptides to B cells, which act as ancillary APC for the induction of T-regulatory cells (T reg ) that inhibit delayed-type hypersensitivity (DTH) responses. Here we show that ocular-like APC induce the expansion of tolerogenic splenic B cells...

.../IFN-gamma treatment in a mouse model induced by grass pollen allergen. XXVth Congress of the EAACI, Vienna, 2006, Abstract 173:57. 23. Sackesen C, Akdis M, Zumkehr J, Alkan S, Blaser K, Gursel I, Akdis CA: Effect of suppressive oligonucleotides on toll-like receptors 3-, 7-, 9-induced B cell...

... in eosinophils does not cause eosinophil-derived neurotoxin or interleukin 8 release and why the survival-promoting activity of CpG ODNs was not found in some eosinophil preparations, we determined the effect of extensive removal of contaminating B cells and plasmacytoid dendritic cells from human eosinophil...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Histamine T cells Dendritic cells B cells Antihistamines Tolerance In addition to its role in the early allergic...

... in the supernatants of adenoid cell cultures from atopic children after 20 h of stimulation (p < 0.05) and a significant correlation with a positive regression between IL-2 and IL-4 was found. Atopy was also associated with a greater increase in the percentage of CD19-positive B cells after stimulation (p...

...Anne C. Roever; Beate M. Henz; Margitta Worm Background: Little is known about the involvement of B cells in venom immunotherapy (VIT). To elucidate changes in the B cell phenotype during this process, we examined the expression of several surface molecules on peripheral B cells before and during...

... of the disease. Consequently, this paper reviews the etiopathogenetic hallmarks, such as impaired amount and presentation of nuclear antigens, production of antinuclear antibodies by T-cell-dependent B cell stimulation and organ damage by anti-dsDNA antibodies or immune complexes that are discussed...

...Ho-Jen Peng; Zo-Nan Chang; Shu-Wen Kuo; Chin-Cheng Lee; Yi-Yiu Tzau Background: It has been shown that antigen presentation by resting B cells can induce tolerance to intravenously administered protein antigens, but the role of resting B cells in the induction of oral tolerance is unclear. Methods...

... the B cell response to mercury in order to better understand the relation between lymphoproliferation and systemic autoimmunity, using the high–responder H–2s strains (A.SW and SJL), the intermediate responder strain BALB/C (H–2d), and the A.TL (H–2tl) and DBA/2 (H–2d) strains which are resistant...