..., instructions or products referred to in the content or advertisements. 2024 Atopy Chronic spontaneous urticaria Anaphylaxis Autoimmunity Allergens Chronic spontaneous urticaria (CSU) is a common skin disease characterized by recurrent wheals and/or angioedema for >6 weeks [ 1...

... to the aberrant immune functions of patients with IEI, autoimmune cytopenia (AIC) may be the initial finding, which makes diagnosis a challenge. We aimed to evaluate the clinical course, laboratory findings, and treatment response of AIC in children with IEI. Methods: Data of children with autoimmune hemolytic...

... versions of IL-2, obtained by either mutating or fusing IL-2 to heterologous molecules or by forming IL-2/(monoclonal) antibody complexes (IL-2C), and discusses their functional implications for addressing such heterologous pathological conditions in cancer, autoimmunity, and allergy. Additionally...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Psoriasis Autoimmunity HLA allele...

...Can Tuzer; Kadriye Terzioglu Introduction: The role of autoimmunity and other preexisting risky conditions in hypersensitivity reactions (HSRs) to COVID-19 vaccines seems unclear. The aim of the study was to investigate the autoimmunity and preexisting risky conditions in HSRs to COVID-19 vaccines...

... such as allergic and autoimmune disorders, especially in children and infants born in this era. In this review, the probable impact of the COVID-19 pandemic on body’s microbiota and its relationship with the emergence of future diseases is discussed. [email protected] 25 09 2021 26 10 2021...

... levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis. Methods: Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency...

... of maintaining Th1 levels via autoreactive CD8+ T cells. Allergic contact dermatitis Atopic dermatitis Autoimmunity Proteasome inhibitor Th1 Blood samples were collected from the orbital sinus in mice using a hematocrit tube, and serum samples were obtained by centrifugation. The total serum...

... by means of the Mann-Whitney U test. The Fisher exact test was used for group comparisons. Results: Patients were diagnosed with type 1 HAE ( n = 14), type 2 HAE ( n = 1), C1-INH-AAE ( n = 8), ACEI-RA ( n = 16), or I-AAE ( n = 26). We included only patients with concomitant autoimmune diseases from the I...

... to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimmunity are associated with the various types of PAD. Both systemic and organ-specific...

...Barbara Frossi; Stefano De Carli; Fleur Bossi; Carlo Pucillo; Marco De Carli Background: Immunoglobulin (Ig) A deficiency is a primary immunodeficiency in which autoimmunity is frequently observed. Thirty to fifty percent of patients with spontaneous chronic urticaria have autoantibodies...

... and a dysregulated immune system. Aside from recurrent infections, the most common complications of CVID are autoimmune complications, particularly autoimmune cytopenias. To date, type 1 diabetes mellitus (T1D) in combination with CVID has only been described as an unusual complication in several reports...

...), which is expressed primarily in lymphoid tissues. The functional but geographically highly variable PTPN22 single-nucleotide polymorphisms (SNPs), particularly c.1858C>T, contribute to the onset and progression of autoimmunity-associated diseases and facilitate the expression of disease-associated...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Antigen affinity Autoimmunity Basophils FcεRI Immunoglobulin E Mast cells Systemic lupus erythematosus National Institutes of Health (NIH) 10.13039/100000002 As mentioned above...

...Lorenzo Cosmi; Francesco Liotta; Enrico Maggi; Sergio Romagnani; Francesco Annunziato Th17 lymphocytes, beyond their protective role in the clearance of extracellular pathogens, also play a role in the pathogenesis of several autoimmune and inflammatory diseases, such as multiple sclerosis...

... serum levels of IgA. Abnormalities of CD4+CD25 high forkhead box P3 (FoxP3)+ regulatory T cells (T reg ) have been shown in association with autoimmune and inflammatory disorders. Methods: In order to evaluate the relationship between autoimmunity and T reg in SIgAD, we studied 26 IgA-deficient patients...

... evidence that cytokine-stimulated B lymphocytes could be a significant source of IL-17A and IL-17F and support the notion that these cells actively participate in immune responses via alternative mechanisms in addition to the classic release of antibodies. Autoimmunity B cells CD40 ligand...

.... Thus, anti-FcΕRI autoantibodies may be part of a conditional autoimmune reaction, leading to urticaria if local IgE is consumed, e.g. after an immediate reaction. Thus, anti-FcΕRI antibodies may represent an amplification arm of the late reaction. The normal occurrence of anti-IgE and anti-IgE receptor...

... such as multiple chemical sensitivity syndrome. Intensified studies should be performed to identify such susceptible MHC genotypes, taking advantage of the reported cases of more heavily metal-exposed humans with systemic autoimmune reactions. Further studies will also be needed to ascertain whether the combined...

... is now recognized as a form of hemophagocytic lymphohistiocytosis that is characteristically associated with autoimmune diatheses. The diagnosis of incipient MAS in patients with autoimmune disease requires a high index of suspicion, as several characteristics of the disorder may be present...