... increased prevalence of autoimmunity, this has not been investigated in HαT populations. Our objective was to describe the prevalence of autoantibodies in individuals with HαT. Methods: We retrospectively studied a cohort of patients with positive genotyping for HαT at a tertiary-care allergy clinic...

..., instructions or products referred to in the content or advertisements. Antinuclear antibody Autoantibody Autoantigen Cytokine IgE antibody Systemic lupus erythematosus Systemic lupus erythematosus is characterized by a loss of immune tolerance to self-antigens, intense and diversified...

... proposed IgG4 + multiorgan lymphoproliferative syndrome (MOLPS). The etiology of IgG4 + MOLPS is still unknown; however, autoantibodies to blood cells in this case suggested that the autoimmune mechanism, which is caused by abnormal immune functions in MDS patients, might be involved in the pathogenesis...

... and cholesterol levels. MX-68 was as effective as MTX at ameliorating events which accompany the development of lupus nephritis, despite that MX-68 did not undergo polyglutamation. These ameliorative effects of MX-68 and MTX did not occur via inhibition of either autoantibody production or cell proliferation...

..., because anti-IgE antibodies can prevent basophil sensitiziation with IgE or even remove IgE-receptor-bound IgE molecules. However, the question remains whether naturally occurring anti-IgE autoantibodies possess similar biological activity. To generate such antibodies for the necessary in vitro studies...

...C.G.M. Magnusson; D.F. Nelson; Maggy A.J. Magnusson The levels of naturally occurring IgG and IgG subclass anti-IgE autoantibodies (a-E Ab) were studied in 71 randomly collected cord sera with ELISA using solid-phase IgE-DES myeloma protein. IgG a-E Ab were present in all cord sera, and the range...

...Margaret-Mary Holyst; Don L. Hill; Gordon C. Sharp; Robert W. Hoffman Mixed connective tissue disease (MCTD) is characterized by the presence of high titers of anti-U1-70kD autoantibodies which are the result of substantial B cell activation. The hprt gene encodes the constitutively expressed...

... highly predictive IgA autoantibodies to tTG. Certain gluten peptides are presented by the disease-associated HLA-DQ2/DQ8 molecules leading to stimulation of gluten-specific T cells. This immune response which is driven in the lamina propria causes the mucosal transformation characteristic for celiac...