... microbes. Asthma and allergic diseases can result from maladaptive immune responses, resulting in exaggerated and persistent type 2 immunity and tissue inflammation. Summary: Among the diverse populations of tissue immune cells, CD4 + regulatory T cells (Treg cells) are central to controlling immune...

...Zengxiao Zhang; Gongfei Li; Shizhe Zhou; Minghui Wang; Longgang Yu; Yan Jiang Introduction: Asthma is associated with upper airway diseases and allergic diseases; however, the causal effects need to be investigated further. Thus, we performed this two-sample Mendelian randomization (MR) analysis...

... the hereditary component later in life. The aim was to investigate IgE-verified and self-reported allergy and asthma at 20 years of age in association to parental allergy and environmental factors. Methods: In total, 281 individuals born into the cohort of well-characterized parents regarding allergic disease...

...Recep Evcen; Fatih Çölkesen; Eray Yıldız; Filiz Sadi Aykan; Mehmet Kılınç; Şevket Arslan Introduction: Sensitivity to indoor allergens increases the risks of asthma and the emergence of allergic diseases. Indoor allergens include house dust mite (HDM), pet dander, cockroach (CR), and molds. We...

... for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Web of Science database was searched in September 2023 to retrieve publications investigating the relationship between allergic rhinitis (AR), atopic dermatitis (AD), or asthma and the following factors: (i) migrant status (i.e., migrants vs...

... role in the lung and, by instructing eosinophils, likely have a foundational role in asthma pathogenesis. Summary: In this review, we discuss various topics related to eosinophil-epithelial cell interactions in asthma, including the influence of eosinophils and eosinophil products, e.g., granule...

...Yuanjun Liu; Haixia Liu; Qi Shao; Hanfen Shi; Fafeng Cheng; Xueqian Wang Introduction: T cells play a critical role in inflammatory diseases. The aim of the present study was to investigate the effects of Majie cataplasm (MJC) on asthma and to propose a possible mechanism involved in this process...

...Chun Xu; Dandan Chai; Ping Zheng; Rongjun Qiu; Xiaocong Pan; Yaqiong Zhang Introduction: This study aim to analyzed the main pollen allergen components that cause allergic asthma and/or rhinitis and the cross-reactions between the allergen components. Methods: Twenty one allergic rhinitis patients...

... in serum were decreased in CRTH2 KO mice compared to WT mice. However, lung histological changes were comparable between WT and CRTH2 KO mice. Conclusion: CRTH2 is responsible for the development of asthma responses in a mouse model of airway inflammation that features prominent involvement of both IgE...

... on asthma patients. Additionally, tiotropium inhibits allergic airway inflammation and remodeling in a murine asthma model. However, the underlying mechanisms of this M3 receptor antagonist remain unclear. Therefore, we investigated the effect of muscarinic M3 receptor blockage on M2 macrophage development...

...Willis S. Bowman; Rebecca J. Schmidt; Gursharan K. Sanghar; George R. Thompson III; Hong Ji; Amir A. Zeki; Angela Haczku Background: Population growth and climate change have led to more frequent and larger wildfires, increasing the exposure of individuals to wildfire smoke. Notably, asthma...

...Daniel P. Potaczek; Stanisława Bazan-Socha; Ewa Wypasek; Małgorzata Wygrecka; Holger Garn Background: Epigenetic modifications are known to mediate both beneficial and unfavorable effects of environmental exposures on the development and clinical course of asthma. On the molecular level, epigenetic...

.... However, concerns regarding potential long-term side effects are brought up by the overuse of PPIs. This study aimed to investigate the relationship between PPI usage, allergy, and asthma in the general US population. Methods: Data of individuals aged ≥20 years who had information on PPI use...

...Xin Guo; Wenjie Sun; Bingbing Zhang Introduction: Clinical management of asthma remains as a prevalent challenge. Monotropein (MON) is a naturally occurring cyclic enol ether terpene glycoside with medical application potential. This study aims to evaluate the potential therapeutic effects of MON...

...Christian Hadiwinarta; Alex Blank; Joshua Somers; Coby Schal; Charles Bronzert; Kavita Sharma; Michael B. Strader; Robert G. Hamilton; Jay E. Slater Introduction: German cockroach (GCr) aeroallergens are associated with allergic rhinitis and asthma. Vitellogenin (Vg) and vitellin (Vn) are abundant...

...Min Shu; Hongbo Xu; Yongsheng Liang; Mengjuan Shi; Ming Chen; Jianghua Guo Introduction: Asthma is a common chronic inflammatory respiratory disease worldwide. The long non-coding RNA (lncRNA) BCYRN1 has been shown to function in the inhibition of smooth muscle cell differentiation and vascular...

... groups, there was no difference in the frequency of allergic diseases, with similar rates of eczema, asthma, and hospital presentations seen. Conclusion: In this follow-up study, infants of mothers who were exposed to probiotics during their pregnancy do not appear to have any paediatric health...

...Mehmet Erdem Cakmak; Nida Öztop; Osman Ozan Yeğit Introduction: Severe asthma is characterized by frequent recurrent airway symptoms and exacerbations, and these affect the quality of life. Biological agents can be used in the treatment of patients with severe asthma if the disease cannot...

...Osamu Matsuno Introduction: Patients with eosinophilic granulomatosis with polyangiitis (EGPA) and some with severe eosinophilic asthma require continuous long-term oral corticosteroid (OCS) treatment for disease control. The anti-interleukin-5 agent, mepolizumab, has recently become available...

...: The full spectrum of bacterial and fungal species in adult asthma and the effect of inhaled corticosteroid use is not well described. The aim was to collect mouthwash and induced sputum samples from newly diagnosed asthma patients in the pretreatment period and in chronic asthma patients while undergoing...