...Haoyang Hu; Qiao-Zhi Qin; Wei Zheng; Zhi-Qiang Xu; Xiang Chen Introduction: House dust mite is the primary trigger of allergic respiratory diseases worldwide, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in the clinic. The use of allergen molecules instead...

...De-Zheng Yang; Jian Tang; Ya-Li Cheng; Yong-shi Yang; Ji-Fu Wei; Jin-Lyu Sun; Zhi-Qiang Xu Introduction: Artemisia species are widely spread in north hemisphere. Artemisia sieversiana pollen is one of the common pollen allergens in the north of China. At present, seven allergens were identified...

...Kenny Y. Kwong; Zhen Chen; Lyne Scott; Lee H. Hilborne Introduction: While a specific number and type of antigens are recognized to detect perennial inhalant allergies, the optimal number and combination of allergens to reliably identify seasonal allergic sensitization is unclear due to limited...

...Regina Treudler Background: Anaphylaxis represents the most severe end of the spectrum of allergic reactions. Frequent elicitors of anaphylaxis are insects, foods, and drugs. This paper summarizes recent development with regard to emerging and novel elicitors of anaphylaxis. Summary: Food allergens...

...Liping Liu; Weihua Wang; Yuemei Sun; Guangrun Li Introduction: Many parents of children with allergies are worried whether their subsequent children will have allergic reactions to the same allergens. Much of the current research on sibling allergens has been focused on twins; however, in real life...

...He Wen; Litian Qu; Yu Zhang; Beilei Xu; Shiqi Ling; Xiaochun Liu; Yang Luo; Da Huo; Wei Li; Xu Yao Background: The efficacy of allergen-specific immunotherapy (AIT) is mainly depended on the tolerogenic immune responses elicited. Properly conjugated nano-vaccine has the advantages of both specific...

...Wei Wang; Xian-hui Zhang; Lei Zhu; Yu-xiang Liu Objective: The objective of this study is to investigate the allergen sensitization pattern among 4,203 children in the Shanxi region of China and to provide guidance for diagnosis and prevention of allergic diseases. Methods: A retrospective analysis...

...Mandana Behbahani; Parisa Rabiei; Hassan Mohabatkar Background: A large number of allergens are derived from plant and animal proteins. A major challenge for researchers is to study the possible allergenic properties of proteins. The aim of this study was in silico analysis and comparison...

... analysis. Results: The geometric mean serum periostin level was 107.6 ng/mL (95% CI 104.5–110.7). After adjustment for confounding, serum periostin levels were significantly associated with sensitization to poly-allergens (adjusted odds ratio, aOR 1.032, 95% CI 1.006–1.059, p = 0.016) and pollen (aOR 1.020...

... of the different allergens in order to identify epitopes that can elicit the cross-reactivity of the sera. Synthetic peptides corresponding to the linear epitope sequence of Der p 5, Der f 5, and Blo t 5 were used to evaluate its implication in the cross-reactivity between the allergens. We also modified...

...Ulbosin Saltabayeva; Victoria Garib; Marina Morenko; Rafail Rosenson; Zhanat Ispayeva; Madina Gatauova; Loreta Zulus; Alexander Karaulov; Felix Gastager; Rudolf Valenta Background: Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen...

...Dwan Price; M. Leigh Ackland; Cenk Suphioglu Background: Peanuts are still one of the highest contributors to anaphylactic deaths after ingestion of a food allergen. At the molecular level, interactions between peanut allergens and the intestinal epithelium are largely unexplored. Previous findings...

...Robert Movérare; Karin Blume; Peter Lind; René Crevel; Åsa Marknell DeWitt; Stella Cochrane Background: Knowledge of human IgG subclass antibody responses to various allergens has been hampered by a lack of reliable standardized assays. The aim here was to develop quantitative immunoassays...

...) Study Team Background: The in-depth characterization of the recently identified house dust mite (HDM) major allergen Der p 23 requires the production of its recombinant counterpart because the natural allergen is poorly extractable from fecal pellets. This study aimed to provide a detailed physico...

...Marjorie S. Morgan; DiAnn L. Vyszenski-Moher; Larry G. Arlian Background: The house dust mite, Euroglyphus maynei, occurs in homes worldwide and is an important source of many allergens. Many patients sensitive to Dermatophagoides farinae and D. pteronyssinus are also sensitive to E. maynei...

...Sten Dreborg Background: Skin prick test results are mostly reported as mean wheal diameter obtained with one concentration of allergen. Differences in technique between personnel causes variation in wheal size. The research question was whether the influence of differences in skin prick test...

...Sten Dreborg; Margareta Holgersson Background: The allergen dose-response curve is flat; thus, small changes in wheal size reflect large differences in skin sensitivity. The sensitivity as measured by provocation tests is given by the threshold concentration that causes symptoms and/or objective...

... allergen sources in subtropical regions of the world. An assay for specific IgE to the major molecular allergenic component, Pas n 1, of Bahia grass pollen (BaGP) would have immunodiagnostic utility for patients with pollen allergy in these regions. Methods: Biotinylated Pas n 1 purified from BaGP...

... process, since 1 h of pretreatment was needed for maximal enhancement. Basophil priming also resulted from preincubation with subthreshold doses of an allergen, Der f 2. In parallel mAb experiments, CRA-1 mAb showed weak priming effects on human umbilical cord blood-derived cultured mast cells; a higher...

...Kyoung Yong Jeong; Chung-ryul Kim; Jina Park; In-Soo Han; Jung-Won Park; Tai-Soon Yong Background: Cockroaches produce potent allergens, and cockroach feces are known to be especially rich in allergens. In this study, we analyze the allergenic components from cockroach feces and evaluate...