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Keywords: Airway remodeling
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Journal Articles
Journal Articles
Int Arch Allergy Immunol (2022) 183 (7): 714–725.
Published Online: 22 February 2022
... induction of AHR. While Balb/c mice showed remodeling of the airways with subepithelial fibrosis and goblet cell metaplasia, airway remodeling in DO11.10 mice was marginal. Both airway inflammation and remodeling resolved after prolonged periods of challenge in both models. In conclusion, strong allergen...
Journal Articles
Int Arch Allergy Immunol (2022) 183 (4): 424–434.
Published Online: 02 December 2021
... Salidroside Airway inflammation Airway remodeling miR-323-3p/SOCS5 Asthma is a chronic respiratory disease, prevailing in 334 million populations globally [1]. It is characterized by intermittent and reversible airway compression and inflammation in response to infection, environmental allergens...
Journal Articles
Int Arch Allergy Immunol (2020) 181 (12): 897–907.
Published Online: 13 August 2020
... to cause airway remodeling and induce allergic airway inflammation in asthma. However, the mechanisms how mechanical stress via bronchoconstriction could induce airway inflammation and remodeling remain unclear. Objective: We investigated the effect of bronchoconstriction induced by methacholine inhalation...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2018) 175 (1-2): 26–35.
Published Online: 18 January 2018
...Kosuke Makita; Yu Mikami; Hirotaka Matsuzaki; Naoya Miyashita; Hideyuki Takeshima; Satoshi Noguchi; Masafumi Horie; Hirokazu Urushiyama; Motoyasu Iikura; Masayuki Hojo; Takahide Nagase; Yasuhiro Yamauchi Background: Asthma is a chronic airway inflammatory disease characterized by airway remodeling...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2013) 161 (1): 65–73.
Published Online: 14 December 2012
... antibody) versus placebo to evaluate the utility of these measurements as possible biomarkers of asthma control and airway remodeling. Methods: Patients with severe, prednisone-dependent asthma received either mepolizumab or placebo as described in a previously published randomized, double-blind, placebo...
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Journal Articles
Journal Articles
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2008) 147 (3): 179–189.
Published Online: 02 July 2008
...W.S. Fred Wong; Jing Zhao Background: Asthma is a chronic airway inflammatory disease characterized by airway wall remodeling. The mechanisms underlying airway remodeling in asthma are not fully understood. There is an urgent need to investigate global protein profiling of chronically inflamed...
Journal Articles
Int Arch Allergy Immunol (2008) 147 (1): 6–16.
Published Online: 30 April 2008
...: Our results demonstrate that CpG ODNs have inhibitory effects on Der f-induced airway hyperresponsiveness and eosinophilia, as well as airway remodeling, and that CpG ODNs can be a therapeutic approach for the treatment of house dust mite-induced asthma. Fig. 1 Experimental protocol for Der f...
Journal Articles
Int Arch Allergy Immunol (2008) 146 (2): 138–148.
Published Online: 18 January 2008
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Airway remodeling Allergy Cytokines Fibroblast growth factor 2 Mitogenesis Stromal cells Allergic asthma...
Journal Articles
Int Arch Allergy Immunol (2006) 142 (1): 19–27.
Published Online: 29 September 2006
... proteins involved in the early response, but its participation in airway remodeling is not established. The present study addressed this question comparing an EPO-deficient mouse strain (NZW) with BALB/c and C57Bl/c strains. Methods: Mice were immunized with ovalbumin/alum, challenged twice with ovalbumin...
Journal Articles
Journal Articles
Int Arch Allergy Immunol (2005) 137 (Suppl. 1): 17–20.
Published Online: 03 June 2005
...Yoshiko Kato; Takao Fujisawa; Hisashi Nishimori; Hajime Katsumata; Jun Atsuta; Kosei Iguchi; Hitoshi Kamiya Eosinophils may play an important role in the pathogenesis of airway remodeling in asthma through the production of various fibrogenic cytokines such as transforming growth factor-β1 (TGF-β1...
Journal Articles
Journal Articles