... for >4 days/week or persist for >4 consecutive weeks. Rhinitis severity was based on estimations of activity impairment (sleep, daily activities, work/school performance, and troublesome behavior) and was classified as severe or moderate [ 1 ]. © 2017 S. Karger AG, Basel 2017 Copyright / Drug...

... participants: Asthma in the elderly: current understanding and future research needs - a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol 2011;128(suppl 3):S4-S24. 5. Braman SS: Growing old with asthma: what are the changes and challenges? Expert Rev Respir Med 2010:4:239-248...

... bone loss but also postmenopausal osteoporosis and osteoporosis associated with aging. 25 9 2012 © 2012 S. Karger AG, Basel 2012 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

... of 44 women and 77 men diagnosed with AD with a mean age of 68.92 ± 6.51 years were evaluated. In 17 (68%) patients with AD and low levels of total IgE, there was a positive correlation between the positive results for enterotoxin B, S. aureus -specific IgE antibodies and Th1 cytokine profiles...

...Amiela Globerson Some of the key features of aging effects on T lymphocytes have been illuminated in the last few years from new angles. Experimental evidence indicates a profound increase in the proportion of memory versus naive types of T cells, a decline in the response to activation...

...Z. Bodnár; M.M. Steger; M. Saurwein-Teissl; C. Maczek; B. Grubeck-Loebenstein Little is known about the type 1/type 2 T cell dichotomy in old age. Peripheral blood mononuclear cells (PBMC) and T cell lines from old and young healthy individuals were therefore analyzed for their production...

... in many physiological systems, but seems to play a special role for the maintenance of immunological homeostasis. In view of the known decline of immune function in old age it seemed of interest to study the expression and inducibility of CD95 in peripheral blood T lymphocytes from young and old healthy...

... and surface marker expression. Furthermore, the effects of cell density in culture, the age of the donor animals, giucocorticoids, and inhibition of protein synthesis were studied. It was found that: (1) apoptotic rat thymocytes are recognized in flow cytometry as small, acridine orange low , CD4 low , CD8...

...Thomas Stulnig; Christian Maczek; Günther Böck; Otto Majdic; Georg Wick Some lymphocyte subpopulations change during aging but age-related reference limits from a healthy reference population are still lacking. In this study, we compiled 90% reference intervals for commonly determined lymphocyte...

... investigated the immunomodulating activity of a new analog of peptidoglycan monomer (PGM), in which the basic molecule was linked to zinc (PGM-Zn). Its effects in BALB/c mice, aged 10–12 months, were compared with the effects of equimolar doses of PGM and ZnCl 2 . The treatment lasted 26 days (one i.p...

...Xiaoning Xu; Ian Beckman; John Bradley T cell responsiveness to in vitro stimulation is severely diminished in the aged. Recent studies would suggest that this may be due, at least in part, to a reduction in interleukin 2 (IL-2) secretion and high-affinity IL-2 receptor (HA-IL-2R) expression...

... mechanism. 3 9 2009 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying...

...E. Masini; E. Gambassi; M. Lupini; A. Pistelli; P.F. Mannaioni Isolated perfused hearts and serosal mast cells (MC) of 2- 6- and 18-month-old spontaneously hypertensive rats (SH) were compared to hearts and MC from Wistar-Kyoto (WKY) rats of the same age for their ability to release nitric oxide...

...Viviana Chavez; Miguel Parreira Soares; Hervé Bazin CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23...

.... Methods: Cross-sectional and vertical-sectional studies were performed regarding the effects of aging on sensitization to Japanese cedar pollen (JCP) and development of JC pollinosis by measuring serum IgE titers to JCP and by oral examination of residents of the Maruyama Town, Chiba, Japan from 1995...

... that the increase in sensitivity of T cells to apoptosis with age may contribute to age-associated immune dysfunction and disorders. Activation-induced apoptosis was performed as described by Radvanyi et al. [ 12 ]. The purified T cells (2 million cells/ml) were plated in a tissue culture flask coated...