Background: Sublingual immunotherapy (SLIT) has been successfully employed in IgE-mediated respiratory allergies. However, it is not known whether the modulation of immune responses in the sublingual area during SLIT has any deleterious effect on oral health. We sought to determine the oral health prospectively in children receiving SLIT for house dust mite allergy. Material and Methods: Eighteen children with allergic asthma and/or rhinitis and 31 age-matched healthy controls (HC) were included in an open-labeled trial. Oral health was evaluated by scoring the decayed, missing, and filled teeth for primary (dmft) and permanent (DMFT) dentition, and the plaque and gingival indices. Moreover, cariogenic food intake and teeth-brushing habits were also noted at baseline and at 19 months. Results: The mean age of the SLIT participants was 9.5 ± 3.1 years and that of the HC was 9.2 ± 3.7 years. The mean duration of SLIT was 19.13 ± 3.81 months. At baseline, the total dmft and DMFT indices were similar in the SLIT and HC groups (p > 0.05), which demonstrated poor hygiene overall. In the within-group comparisons at the examination at 19 months, the SLIT group had a lower number of carious primary teeth and a higher number of filled primary teeth compared to the count at baseline (p = 0.027 and p = 0.058, respectively). Conclusion: Our study showed no detrimental effect of SLIT on oral health during a period of 19 months of follow-up. Parents should be motivated to use dental health services to prevent new caries formation since our cohort had overall poor oral hygiene at the baseline.

Bousquet J, Lockey RF, Malling HJ: WHO position paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 1998;53:1-42.
Bacharier LB, Boner A, Carlsen KH, et al: Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy 2008;63:5-34.
Canonica GW, Bousquet J, Casale T, Lockey RF, Baena-Cagnani CE, Pawankar R, et al: Sublingual Immunotherapy: World Allergy Organization Position Paper 2009. Allergy 2009;64(suppl 91):1-59.
Moingeon P, Mascarell L: Induction of tolerance via the sublingual route: mechanisms and applications. Clin Dev Immunol 2012;2012:623474.
Akdis CA, Barlan IB, Bahceciler N, Akdis M: Immunological mechanisms of sublingual immunotherapy. Allergy 2006;61:11-14.
Adlerberth I, Strachan DP, Matricardi PM, Ahrné S, Orfei L, Aberg N, Perkin MR, Tripodi S, Hesselmar B, Saalman R, Coates AR, Bonanno CL, Panetta V, Wold AE: Gut microbiota and development of atopic eczema in 3 European birth cohorts. J Allergy Clin Immunol 2007;120:343-350.
Mascarell L, Lombardi V, Louise A, et al: Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells. J Allergy Clin Immunol 2008;122:603-609.
Allam JP, Stojanovski G, Friedrichs N, Peng W, Bieber T, Wenzel J, Novak N: Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 2008;63:720-727.
Wilkins EM (ed): Clinical Practice of the Dental Hygienist. Philadelphia, Lippincott, Williams and Wilkins, 1999.
Paes Leme AF, Koo H, Bellato CM, Bedi G, Cury JA: The role of sucrose in cariogenic dental biofilm formation - new insight. J Dent Res 2006;85:878-887.
Takahashi N, Nyvad B: The role of bacteria in the caries process: ecological perspectives. J Dent Res 2011;90:294-303.
Moynihan P, Petersen PE: Diet, nutrition and the prevention of dental diseases. Public Health Nutr 2004;7:201-226.
Moraes JJ, Stipp RN, Harth-Chu EN, Camargo TM, Höfling JF, Mattos-Graner RO: Two-component system VicRK regulates functions associated with establishment of Streptococcus sanguinis in biofilms. Infect Immun 2014;82:4941-4951.
Bowen WH, Koo H: Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms. Caries Res 2011;45:69-86.
Ali HM, Mustafa M, Hasabalrasol S, Elshazali OH, Nasir EF, Ali RW, Berggreen E, Skeie MS: Presence of plaque, gingivitis and caries in Sudanese children with congenital heart defects. Clin Oral Investig 2017;21:1299-1307.
Crapo RO, Casaburi R, Coates AL, et al: Guidelines for methacholine and exercise challenge testing - 1999. Am J Respir Crit Care Med 2000;161:309-329.
Silness J, Loe H: Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:121-135.
Loe H: The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-616.
Loe H, Silness J: Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-551.
Sisman N, Bora N, Catar RO, Karacayli U, Cimilli H, Koksal L, Oktay I, Mumcu G: Utilization of dental service and quality of life in preschool children. Int J Exp Dent Sci 2016;5:16-22.
Tomazoni F, Vettore MV, Zanatta FB, Tuchtenhagen S, Moreira CH, Ardenghi TM: The associations of socioeconomic status and social capital with gingival bleeding among school children. J Public Health Dent 2017;77:21-29.
Angelopoulou M, Kavvadia K, Oulis C, Reppa C: Oral hygiene facilitators and barriers in Greek 10-year-old schoolchildren. Int J Clin Pediatr Dent 2015;8:87-93.
Subasi F, Mumcu G, Koksal L, Cimilli H, Bitlis D: Factors affecting oral health habits among children with cerebral palsy: pilot study. Pediatr Int 2007;49:853-857.
Alaki SM, Ashiry EA, Bakry NS, Baghlaf KK, Bagher SM: The effects of asthma and asthma medication on dental caries and salivary characteristics in children. Oral Health Prev Dent 2013;11:113-120.
Matthews J: Asthma and dental caries. Evid Based Dent 2012;13:41.
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