Background: IgE sensitization is a prerequisite for the development of allergic symptoms. The investigation of factors influencing the development of IgE is therefore crucial for understanding the onset of allergic diseases. Methods: This epidemiological study investigated personal, intrinsic, and lifestyle factors in a nonselected cohort of 501 Austrian adolescents (aged 12-21 years). IgE levels to 112 allergen molecules were analyzed in the serum of participants using the ImmunoCAP ISAC®. Allergic sensitization, IgE levels to single allergens, and ISAC score sums were correlated with results obtained from a questionnaire. Results: In this adolescent cohort, male participants showed a higher sensitization frequency (56.8%) compared to females (50.9%) and significantly increased IgE levels to profilins. Underweight subjects demonstrated a stronger IgE sensitization. Family size inversely correlated with IgE levels to PR-10 allergens, and predominately paternal allergies were a predictive factor for IgE sensitization in the children. Vaccination, breastfeeding, and delivery mode showed no influence, while a highly protective effect was observed for growing up on a farm. Of all of the investigated lifestyle factors, only smoking significantly influenced the risk for IgE development. Participants with moderate frequencies of colds showed increased sensitization levels. Conclusion: A hereditary predisposition and lifestyle factors such as a farming environment, smoking, family size, body weight, or frequency of colds significantly influenced the development of allergen-specific IgE in this cohort of adolescents.

Keywords:
Allergen sensitization, Antigens/allergens, Childhood, Environmental factors, Epidemiology, Farm environment, IgE antibodies, Microarray, Molecular diagnostics
1.
Akdis CA, Agache I (eds): Global Atlas of Allergy. Zurich, European Academy of Allergy and Clinical Immunology 2014.
2.
Kramer U, Oppermann H, Ranft U, Schafer T, Ring J, Behrendt H: Differences in allergy trends between East and West Germany and possible explanations. Clin Exp Allergy 2010;40:289-298.
3.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, et al: EAACI molecular allergology user's guide. Pediatr Allergy Immunol 2016; 27(suppl 23):1-250.
4.
Rosenwasser LJ: Genetics of asthma and atopy. Toxicol Lett 1996;86:73-77.
5.
Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wuthrich B: Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy 1999;29:28-34.
6.
Riedler J, Eder W, Oberfeld G, Schreuer M: Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000;30:194-200.
7.
von Mutius E, Vercelli D: Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 2010;10:861-868.
8.
Stemeseder T, Klinglmayr E, Moser S, Lueftenegger L, Lang R, Himly M, Oostingh GJ, Zumbach J, Bathke AC, Hawranek T, Gadermaier G: Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling. Allergy 2017;72:754-763.
9.
Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Matricardi PM: Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 2012;130:894-901.e895.
10.
Schmitz R, Ellert U, Kalcklosch M, Dahm S, Thamm M: Patterns of sensitization to inhalant and food allergens - findings from the German Health Interview and Examination Survey for Children and Adolescents. Int Arch Allergy Immunol 2013;162:263-270.
11.
Riedler J, Gamper A, Eder W, Oberfeld G: Prevalence of bronchial hyperresponsiveness to 4.5% saline and its relation to asthma and allergy symptoms in Austrian children. Eur Respir J 1998;11:355-360.
12.
Skaaby T, Husemoen LL, Thuesen BH, Jorgensen T, Linneberg A: Lifestyle-related factors and atopy in seven Danish population-based studies from different time periods. PLoS One 2015;10:e0137406.
13.
Salo PM, Arbes SJ Jr, Jaramillo R, Calatroni A, Weir CH, Sever ML, Hoppin JA, Rose KM, Liu AH, Gergen PJ, Mitchell HE, Zeldin DC: Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol 2014;134:350-359.
14.
Scala E, Alessandri C, Palazzo P, Pomponi D, Liso M, Bernardi ML, Ferrara R, Zennaro D, Santoro M, Rasi C, Mari A: IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology. PLoS One 2011;6:e24912.
15.
De Amici M, Ciprandi G: The age impact on serum total and allergen-specific IgE. Allergy Asthma Immunol Res 2013;5:170-174.
16.
Flexeder C, Thiering E, Bruske I, Koletzko S, Bauer CP, Wichmann HE, Mansmann U, von Berg A, Berdel D, Kramer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J: Growth velocity during infancy and onset of asthma in school-aged children. Allergy 2012;67:257-264.
17.
Rzehak P, Wijga AH, Keil T, Eller E, Bindslev-Jensen C, Smit HA, Weyler J, Dom S, Sunyer J, Mendez M, Torrent M, Vall O, Bauer CP, Berdel D, Schaaf B, Chen CM, Bergstrom A, Fantini MP, Mommers M, Wahn U, Lau S, Heinrich J: Body mass index trajectory classes and incident asthma in childhood: results from 8 European birth cohorts - a Global Allergy and Asthma European Network initiative. J Allergy Clin Immunol 2013;131:1528-1536.
18.
Byberg KK, Eide GE, Forman MR, Juliusson PB, Oymar K: Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood. Clin Transl Allergy 2016;6:33.
19.
Svanes C, Jarvis D, Chinn S, Burney P: Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;103:415-420.
20.
Enroth S, Dahlbom I, Hansson T, Johansson A, Gyllensten U: Prevalence and sensitization of atopic allergy and coeliac disease in the Northern Sweden Population Health Study. Int J Circumpolar Health 2013;72.
21.
Grabenhenrich LB, Gough H, Reich A, Eckers N, Zepp F, Nitsche O, Forster J, Schuster A, Schramm D, Bauer CP, Hoffmann U, Beschorner J, Wagner P, Bergmann R, Bergmann K, Matricardi PM, Wahn U, Lau S, Keil T: Early-life determinants of asthma from birth to age 20 years: a German birth cohort study. J Allergy Clin Immunol 2014;133:979-988.
22.
Grabenhenrich LB, Keil T, Reich A, Gough H, Beschorner J, Hoffmann U, Bauer CP, Forster J, Schuster A, Schramm D, Nitsche O, Zepp F, Lee YA, Bergmann R, Bergmann K, Wahn U, Lau S: Prediction and prevention of allergic rhinitis: a birth cohort study of 20 years. J Allergy Clin Immunol 2015;136:932-940.e912.
23.
Wu CC, Chen RF, Kuo HC: Different implications of paternal and maternal atopy for perinatal IgE production and asthma development. Clin Dev Immunol 2012;2012:132142.
24.
Canfield SM, Jacobson JS, Perzanowski MS, Mellins RB, Zemble RM, Chew GL, Goldstein IF: Total and specific IgE associations between New York City Head Start children and their parents. J Allergy Clin Immunol 2008;121:1422-1427.
25.
Gruber C, Illi S, Lau S, Nickel R, Forster J, Kamin W, Bauer CP, Wahn V, Wahn U: Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics 2003;111:e282-e288.
26.
Kolokotroni O, Middleton N, Gavatha M, Lamnisos D, Priftis KN, Yiallouros PK: Asthma and atopy in children born by caesarean section: effect modification by family history of allergies - a population based cross-sectional study. BMC Pediatr 2012;12:179.
27.
Prescott S, Nowak-Wegrzyn A: Strategies to prevent or reduce allergic disease. Ann Nutr Metab 2011;59(suppl 1):28-42.
28.
Huang C, Liu W, Cai J, Weschler LB, Wang X, Hu Y, Zou Z, Shen L, Sundell J: Breastfeeding and timing of first dietary introduction in relation to childhood asthma, allergies, and airway diseases: a cross-sectional study. J Asthma 2016, Epub ahead of print.
29.
Jelding-Dannemand E, Malby Schoos AM, Bisgaard H: Breast-feeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years. J Allergy Clin Immunol 2015;136:1302-1308.
30.
Genuneit J, Weinmayr G, Radon K, Dressel H, Windstetter D, Rzehak P, Vogelberg C, Leupold W, Nowak D, von Mutius E, Weiland SK: Smoking and the incidence of asthma during adolescence: results of a large cohort study in Germany. Thorax 2006;61:572-578.
31.
Yao TC, Chang SW, Hua MC, Liao SL, Tsai MH, Lai SH, Tseng YL, Yeh KW, Tsai HJ, Huang JL: Tobacco smoke exposure and multiplexed immunoglobulin E sensitization in children: a population-based study. Allergy 2016;71:90-98.
32.
Barlow SE: Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120:S164-S192.
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