Sensitisation to peach lipid transfer protein (LTP; Pru p 3) is significantly associated with severe allergic symptoms in adults, but little is known about the age at onset of peach allergy. We investigated a possible correlation between specific IgE levels to Pru p 3 and the age at onset of peach allergy. One hundred and forty-eight patients allergic to peach were divided into 6 classes according to the age at onset. Sera were analyzed for IgE antibodies to peach, rPru p 3, rPru p 1, rPru p 4, rBet v 1, rBet v 2, total IgE titre, and tryptase; all collected data were statistically analysed. A significant inverse correlation was found between the age at onset of peach allergy and anti-rPru p 3 IgE levels at diagnosis (p < 0.0005; Spearman's ρ = -0.3833). In contrast, the age at onset was directly correlated with both anti-rPru p 1 IgE levels (p = 0.0001; Spearman's ρ = 0.3197) and anti-rBet v 1 IgE levels (p = 0.0006; Spearman's ρ = 0.2914) at diagnosis. No correlations were detected between the reported age at onset and anti-peach, anti-rPru p 4, anti-rBet v 2 IgE and total IgE values and serum tryptase levels. At diagnosis, when peach allergy starts at a younger age, it is likely associated with Pru p 3 sensitisation, and the younger the onset, the higher the IgE titres. When peach allergy starts at an older age, it is more likely the result of cross-reactivity to Bet v1.

Fernández-Rivas M, González-Mancebo E, Rodríguez-Pérez R, Benito C, Sánchez-Monge R, Salcedo G, et al: Clinically relevant peach allergy is related to peach lipid transfer protein, Pru p 3, in the Spanish population. J Allergy Clin Immunol 2003;112:789-795.
Asero R, Antonicelli L, Arena A, Bommarito L, Caruso B, et al: Causes of food-induced anaphylaxis in Italian adults: a multi-centre study. Int Arch Allergy Immunol 2009;150:271-277.
Gamboa PM, Cáceres O, Antepara I, Sánchez-Monge R, Ahrazem O, Salcedo G, Barber D, Lombardero M, Sanz ML: Two different profiles of peach allergy in the north of Spain. Allergy 2007;62:408-414.
Pastorello EA, Farioli L, Pravettoni V, Scibilia J, Mascheri A, et al: Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4. Int Arch Allergy Immunol 2011;156:362-372.
Novembre E, Mori F, Contestabile S, Rossi ME, Pucci N: Correlation of anti-Pru p 3 IgE levels with severity of peach allergy reactions in children. Ann Allergy Asthma Immunol 2012;108:271-274.
Conover WJ: Practical Nonparametric Statistics, ed 3. New York, John Wiley and Sons, 1999.
Asero R, Antonicelli L, Arena A, Bommarito L, et al: EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. Clin Exp Allergy 2009;39:547-555.
Asero R: Birch and ragweed pollinosis north of Milan: a model to investigate the effects of exposure to ‘new' airborne allergens. Allergy 2002;57:1063-1066.
Asero R, Massironi F, Velati C: Detection of prognostic factors for oral allergy syndrome in patients with birch pollen hypersensitivity. J Allergy Clin Immunol 1996;97:611-616.
Geroldinger-Simic M, Zelniker T, Aberer W, Ebner C, Egger C, et al: Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol 2011;127:616-622.
Pastorello EA, Farioli L, Scibilia G, Pravettoni V, Mascheri A, Stafylaraki C, Nichelatti M, Asero R: Baseline tryptase levels are related to age, total IgE and anti-rPru p 3 IgE levels in peach allergic patients. J Investig Allergol Clin Immunol 2013, accepted for publication.
Asero R, Mistrello G, Roncarolo D, Amato S: Relationship between peach lipid transfer protein specific IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Ann Allergy Asthma Immunol 2004;92:268-272
Asero R, Mistrello G, Roncarolo D, Amato S, Calderoni G, Barocci F, van Ree R: Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002;57:900-906.
Borghesan F, Mistrello G, Roncarolo D, Amato S, Plebani M, Asero R: Respiratory allergy to lipid transfer protein. Int Arch Allergy Immunol 2008;147:161-165.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.